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Microsoft word - citalopram hydrobromide oral solution.doc
Page 1 of 3 – Citalopram Hydrobromide Oral Solution 2 mg/mL
IN CASE OF EMERGENCY
Emergency Phone: (614) 276-4000
Material Safety Data Sheet
1. CHEMICAL PRODUCT AND COMPANY IDENTIFICATION
Common/Trade Name: Citalopram Hydrobromide Oral Solution 10 mg/ 5 mL
Chemical Name: 1-(3-dimethylaminopropyl)-1-(p-fluoropheny)-5-phthalancarbonitrile hydrobromide
Molecular Formula: C20H22BrFN2O
Molecular Weight: 405.35
CAS No: 59729-32-7
Chemical Family: Selective serotonin reuptake inhibitor (SSRI)
Product Use: Antidepressant
Manufacturer’s Name: Boehringer Ingelheim Roxane Inc.
Address: 1809 Wilson Road
Columbus, Ohio 43228
2. COMPOSITION / INFORMATION ON INGREDIENTS
Citalopram Hydrobromide (active ingredient) 59729-32-7
REFER to PHYSICIAN’S DESK REFERENCE for common components present as <1%
3. HAZARDS IDENTIFICATION
Physical State: Liquid solution administered orally.
Peppermint flavored oral solution with 10 mg/5 mL active ingredient.
May be harmful if swallowed.
Accidental ingestion of large amounts may be fatal.
Inhalation: Not expected to be an inhalation hazard in final pharmaceutical form.
Eye Contact: Not expected to be a hazard to the eye. Contact with eye may cause irritation,
burning and redness.
Skin Contact: Not expected to be a hazard to the skin. Can cause hypersensitive reactions
resulting in rash, redness, itching and inflammation.
Ingestion: May be harmful if ingested. Ingestion may cause headache, nausea, dizziness,
fatigue, and fast heartbeat.
See Section 11
The potential for exposure is reduced in finished pharmaceutical form.
Overexposure by ingestion may cause nausea, headache, oedema and heart palpitations.
Brain, Central Nervous System
4. FIRST AID MEASURES
Any material that contacts the eye should be washed out immediately with water. If easy to do,
remove contact lenses if worn. Get medical attention if symptoms persist.
Wash with soap and water. Get medical attention if symptoms occur.
Page 2 of 3 – Citalopram Hydrobromide Oral Solution 2 mg/mL
Call a physician or poison control center immediately.
Should not pose a hazard in the final form. If breathing is difficult, move to fresh air. Get
medical attention immediately.
5. FIRE AND EXPLOSION HAZARDS
Lower: N/A Upper: N/A
Use water spray, carbon dioxide, dry chemical, foam or material appropriate for fire
in surrounding area.
Special Fire Fighting
Wear full protective clothing and self-contained breathing apparatus.
Carbon dioxide, carbon monoxide, oxides of nitrogen, hydrogen bromide,
6. ACCIDENTAL RELEASE INFORMATION
STEPS TO BE TAKEN IF SIGNIFICANT QUANTITIES OF LIQUID IS SPILLED:
Use appropriate personal protective equipment (see Section 8). Wipe up and containerize spill material in a
compatible container. Dispose according to applicable regulations. Incineration of the waste at an approved facility
7. PRECAUTIONS FOR SAFE HANDLING AND USE
Observe good industrial hygiene practices.
Store at 20° to 25°C (68° to 77°F). Keep container closed tightly. Protect from light and
moisture. Store away from foodstuffs.
8. CONTROL MEASURES AND PERSONAL PROTECTIVE EQUIPMENT
Not required when handling liquid or containers. Good ventilation should be used.
Ventilation should be matched to conditions.
Not required when handling liquid or containers. NIOSH/MSHA approved respirators for
protection should be used if respirators are found to be necessary. Ventilation should be
matched to conditions.
Not required when handling final product. If containers are compromised or exposure is
likely wear: Goggles, Lab Coat, Gloves
Eye wash, washing facilities
9. PHYSICAL / CHEMICAL CHARACTERISTICS
10. STABILITY AND REACTIVITY DATA
Oxides of carbon, oxides of nitrogen, hydrogen bromide, hydrogen fluoride
Excessive heat and light
Page 3 of 3 – Citalopram Hydrobromide Oral Solution 2 mg/mL
Will not occur.
11. TOXICOLOGICAL INFORMATION
LD50 Oral (rat): approximately 800 mg/kg
Carcinogenicity: Not listed as a carcinogen by NTP, IARC Monographs or OSHA.
12. ENVIRONMENTAL IMPACT INFORMATION
No information is currently available on the environmental impact of this product.
13. DISPOSAL INFORMATION
Waste Disposal Considerations: Dispose of material according to federal, state and local disposal regulations or
company operating procedures. Disposal by incineration is recommended.
At home: Discard away from children’s reach.
14. TRANSPORTATION INFORMATION
This product is not subject to the regulations for the safe transport of hazardous chemicals.
DOT: Not regulated
TDG: Not regulated
IATA: Not regulated
IMDG: Not regulated
15. REGULATORY INFORMATION
DEA: Citalopram Hydrobromide is not a controlled substance.
FDA: Citalopram Hydrobromide is an approved prescription medication.
This material is not listed on the US TSCA Inventory. Therefore, it can only be used for TSCA exempt purposes such
as R&D or drug use.
This material is not listed on the DSL Inventory but is exempt.
16. OTHER DATA
N/A – not applicable
Prepared by: Boehringer Ingelheim Roxane Inc.
1. Citalopram Hydrobromide Oral Solution, Package Insert, Boehringer Ingelheim Roxane Inc., Columbus, Ohio
2. RTECS No. NP6406750 for 5-Isobenzofurancarbonitrile, 1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-
3. Ariel Webinsight. Regulatory and ChemExpert Database.
4. PDR – Physicians Desk Reference
Date: 09/13/2008 - New MSDS
SEE CURRENT PACKAGE INSERT FOR FURTHER INFORMATION
The information provided is believed to be complete and accurate. If this product is combined with other materials, deteriorates or
becomes contaminated, it may pose hazards not mentioned in this MSDS. It is the users’ responsibility to use the information
according to the application. Boehringer Ingelheim Roxane Inc. assumes no responsibility or liability resulting from the use of this
Julia Hughes HNC/D Animal Studies Module: Microbiology Microbiology: Practical Competence Introduction Infectious diseases in animals are caused by the invasion of tissues by bacteria, especially the epithelium, by microorganisms. This invasion have many effects which can be detrimental to the animals health, let alone be passed on to other animals through physical contact,
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