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DIVISION OF RESEARCH AND GRADUATE STUDIES
OFFICE OF RESEARCH SAFETY
UNIVERSITY CHEMICAL HYGIENE PLAN
OFFICE OF RESEARCH SAFETY
University Chemical Hygiene Plan
Purpose . 3 Scope . 3 Responsibilities. 3 Departmental Chemical Hygiene Plan. 4 Information to be Given to All Affected Employees. 4 Training to be Given to All Affected Employees . 4 Laboratory Safety Rules . 5 Standard Laboratory Procedures. 6 Labeling. 6 Material Safety Data Sheets. 6 Chemical Management . 6 Chemical Storage. 7 Flammable Liquid Storage . 7 Corrosives Storage. 7 Approvals . 7 High Hazardous Substance Precautions . 7 Housekeeping, maintenance, and inspections. 9 Personal Protective Equipment. 9 Medical Consultation and Examinations. . 10 Laboratory Ventilation . 10 Records . 11 Corrective Actions. 11 Appendix A Standard Laboratory Procedures . 12 Compressed Gases. 12 Cryogenic Materials . 12 Peroxidizable Materials . 12 Perchloric Acid . 13 Electrical Equipment . 13 Working Alone . 14 Unattended Operations . 14 Glassware . 14 Laboratory (Fume) Hood Usage.14
Appendix B High Hazardous Substances . 16 Appendix C Sample Posting for Designated Areas . 22 Appendix D Definitions. 23 Appendix E Laboratory Inspection Report . 26 Appendix G Record of Laboratory Safety Meeting. 30 1. Purpose{tc "Purpose"}
1. To establish the minimum requirements for compliance with OSHA's "Standard for Exposure to Hazardous Chemicals in Laboratories", 29 CFR 1910.1450 and to minimize exposure of laboratory personnel to health and physical hazards presented by hazardous chemicals used in laboratories at Kent State University 2. Scope{tc "Scope"}
1. This policy applies to all laboratories in Biology, Chemistry, Liquid Crystal Institute, Physics, Psychology and Geology Departments. 1. 29 CFR 1910.1450 OSHA Standard for Exposure to Hazardous Chemicals in Laboratories. 2. Prudent Practices for Handling Hazardous Chemicals in laboratories. National Research Council. Washington, D.C. National Academy Press, 1995. 3. CRC Handbook of Laboratory Safety 4th edition. A.K. Furr, ed. Boca Raton, Fl: CRC Press, 4. Improving Safety in the Chemical Laboratory: A Practical Guide 2nd ed. J. A. Young, ed. New 1. For the purposes of this policy, a Laboratory Employee is any person (faculty, researcher, assistant, staff, student) receiving compensation for working or conducting research in a laboratory listed in the above Scope. 5. Responsibilities{tc "Responsibilities"}
1. Committee on Hazardous and Radioactive Materials (CHARM) 1. Provide oversight and assistance for managing the university's laboratory chemical safety 2. Maintain representation from all affected departments and community officials. 1. Appoint a Chemical Hygiene Officer (DCHO) or Committee for the Department. 2. Implement and maintain a The KSU Chemical Hygiene Plan and ensure compliance with 3. Principal investigators and laboratory supervisors in areas engaged in the laboratory use of 1. Ensure all operations are conducted in accordance with DCHP. 2. Ensure all students and employees working in their labs comply with DCHP and UCHP. 4. Employees and students engaged in the laboratory use of hazardous chemicals are responsible for complying with department and individual CHPs. 5. The Departmental Chemical Hygiene Officer is responsible for coordinating the implementation of the KSU Chemical Hygiene Plan and for providing technical assistance to laboratory workers. 6. Research and Graduate Studies, Office of Research Safety, Manager of Laboratory Safety. 1. Serve as the University Chemical Hygiene Officer 2. Assist in the development of departmental and individual Chemical Hygiene Plans; 3. Determine Industrial Hygiene monitoring requirements. 4. Coordinate with Occupational Physician the medical examination requirements of 5. Monitor and inspect laboratories to determine compliance with federal, state and local 6. Assist with the development of safety training and education programs for CHP 7. Annual review of the University Chemical Hygiene Plan implementation. 6. KSU Chemical Hygiene Plan{tc "Departmental Chemical Hygiene Plan"}
1. Each Department covered under the scope of this policy will maintain a copy of the KSU Chemical Hygiene Plan in each lab or provide internet access to the online version. 7. Information to be Given to All Affected Employees {tc "Information to be Given to All Affected
Employees "}
1. Each department shall ensure that all Laboratory Employees in the department who are involved in the laboratory use of hazardous chemicals receive the information and training required by this policy. 1. Laboratory personnel who have had training under the Chemical Hygiene Plan are not required to have Hazard Communication training. 2. The following information shall be provided to laboratory personnel at the time of initial 1. "Occupational Exposure to Hazardous Chemicals in Laboratories" 29 CFR 1910.1450 2. Location of the University and Departmental Chemical Hygiene Plan. 3. The permissible exposure limits and recommended exposure limits for chemicals are found on the Material Safety Data Sheet for that chemical. Permissible Exposure Levels are also found in OSHA PEL, 29 CFR 1910.1000 available at Manager, Laboratory Safety Office. ACGIH recommended exposure levels are available at the Manager, Laboratory Safety Office. 4. Signs and symptoms associated with exposures to hazardous chemicals used in the laboratory are found in the "Health Effects" section of the Material Safety Data Sheet for the chemical. 5. Additional safety reference material available on campus includes: 1. Material Safety Data Sheets (MSDS) received from the chemical supplier. These are available on-line; see your supervisor or Departmental Chemical Hygiene Officer for instructions on how to access the system. MSDS of chemicals unique to a specific laboratory are maintained in that laboratory and in the Department Chemical Hygiene Officer's office. 2. The following are available from the Manager, Laboratory Safety. 3. Prudent Practices for Handling Hazardous Chemicals in Laboratories. National Research Council. Washington, D.C. National Academy Press, 1981. 4. CRC Handbook of Laboratory Safety 4th edition. A.K. Furr, ed. Boca Raton, Fl: 5. Improving Safety in the Chemical Laboratory: A Practical Guide 2nd ed. J. A. 6. Safe Storage of Laboratory Chemicals: A. Pipitone, ed. New York: Wiley, 7. Dangerous Properties of Industrial Materials 7th ed. N.I. Sax and R.J. Lewis, Sr. eds. New York: Van Nostrand Reinhold, 1987. 8. Laboratory Health and Safety Handbook. R.S. Stricoff. New York: Wiley: 1990. 9. Destruction of Hazardous Chemicals in the Laboratory. G. Lunn and E.B. 10. Hazardous Laboratory Chemicals Disposal Guide. M.A. Armour, Ph.D. Boca 11. Information on laboratory safety will be furnished to all affected employees throughout the year by periodic laboratory safety meetings, mailings and postings. 8. Training to be Given to All Affected Employees{tc "Training to be Given to All Affected Employees"}
1. The contents of the OSHA standard, which governs the use of potentially hazardous chemicals in laboratories [29 CFR 1910.1450]. A full copy of the standard will be made available during initial training while the major provisions will be reviewed during periodic retraining. 2. The location, availability and details of this Chemical Hygiene Plan. 3. Understanding the signs and symptoms associated with overexposure to hazardous chemicals used in the laboratory as found on the MSDFS, 4. The location and availability of reference material concerning the hazards, safe handling, storage, 5. How laboratory employees can protect themselves from the potential hazards of the chemicals they work with including work practices, personal protective equipment, and emergency procedures. 6. Department specific training will consist of: 1. Methods and observations that may be used to detect the presence or release of a unique hazardous chemical they may be using in that lab. 2. The physical and health hazards of unique hazardous chemicals in the work area. 3. The measures that can be taken to protect oneself from these hazards, including specific procedures the Department has implemented to protect persons from exposure to hazardous chemicals, such as engineering controls, appropriate safe work/lab practices, emergency procedures, and personal protective equipment to be used. General training will be given to all Laboratory Employees by Office of Risk Management or Manager, Laboratory Safety. Sessions for new Laboratory Employees will be given before the start of the new school year in the Fall. Laboratory Employees starting work in the middle of the school year will be trained on an as-needed basis. 8. Department training will be given by Principle Investigator or Supervisor of the affected 9. Appendix F contains recommended documentation to use for recording training. 9. Laboratory Safety Rules{tc "Laboratory Safety Rules"}
1. Know the location of emergency showers, eyewash fountains, first aid kits, emergency exits, spill kits, and fire alarm pull stations. Know the location of the nearest telephone. In an emergency, call 911 from a campus phone. 2. Know the location of Material Safety Data Sheets. Ensure that you have been trained on the 3. No smoking, food, beverage, smokeless tobacco, or application of cosmetics in the laboratory, except in designated areas in which no chemicals are used or stored. 4. Dress appropriately. Long hair, neckties, or loose clothing should be tied back or otherwise secured. No sandals, open-toed or perforated shoes in the laboratory. Shorts or skirts are not to be worn when working with chemicals in a laboratory. 5. Appropriate eye protection will be worn at all times in laboratories. 6. Wear the appropriate personal protective equipment for the chemicals you are working with. 7. Comply with warning signs and labels. 8. Laboratories with special or unusual hazards should be posted with appropriate warning signs including: laser warning signs, radioactivity warning signs, biological hazard warning signs, etc. 9. Do not directly smell or taste any chemical. Do not pipette or siphon by mouth. 10. Containers should be closed when not in use. 11. Always add acid to water. (Alphabetically, acid comes before water). 12. Perform only those experiments or procedures that you are authorized to do by the person in 13. Report all injuries, fires, and accidents to your supervisor or instructor. All fires shall be reported 14. If you have a question about a procedure or the hazards of a chemical, ask your supervisor or instructor before performing the procedure. 15. Never work alone in a laboratory or chemical storage area unless other individuals know of your presence and appropriate means are available to summon assistance. 16. Access to emergency equipment, safety showers, eye wash stations, and exits must never be 17. All chemicals must be labeled with at least the identity of the contents of the container and the potential hazards associated with the chemical. 18. Waste materials must be properly labeled and stored in an appropriate manner. 19. Wash promptly with mild soap and water after any chemical contacts the skin. 20. Avoid inhalation of chemicals. Do not "sniff" chemicals to determine their identity or for other 10. Standard Laboratory Procedures {tc "Standard Laboratory Procedures "}
1. Appendix A contains procedures for the safe use of Compressed Gases, Cryogenic Materials, Peroxidizable Materials, Perchloric Acid, Electrical Equipment, Working Alone, Unattended Operations, Glassware and Laboratory Hoods. 2. Appendix B lists Particularly Hazardous Substances and details procedures for handling them. 11. Labeling {tc "Labeling "}
1. All containers of hazardous substances shall be appropriately labeled. The manufacturer's label shall not be removed from a container as long as the material or residues of the material remain in the container. 2. All original containers will be labeled with a barcode generated by the CisPro inventory system. 3. All containers stored in common use storage areas, refrigerators or cabinets will be labeled with 4. All secondary containers into which hazardous substances are transferred or prepared shall also contain labels that provide the following information. 1. Identity of the hazardous substance. (Chemical name and supplier code number, or, if a synthesized material, a lab book number or reference number.) 5. All hazardous materials collection containers should be labeled with the following: 1. Type waste in container (e.g. Non-Halogenated, Halogenated, Acid, Base, etc.) 2. Statement or statements that call attention to the particular hazardous properties of the material (e.g., flammable, corrosive, etc.) 3. Labeling is not required for portable containers into which hazardous chemicals are transferred from labeled containers that are intended only for the immediate use of the individual who performs the transfer. 6. Where hazardous materials are transported by piping systems, above ground pipes shall be 1. Preferably by stenciling the name or abbreviation of the chemical and an arrow, indicating direction of flow of the material, or, 2. Permanently marking or attaching tags of metal or other suitable material naming the 12. Material Safety Data Sheets{tc "Material Safety Data Sheets"}
1. MSDS for chemicals unique to a specific laboratory will be kept in that laboratory and by the 2. MSDSs for unique chemicals must accompany that chemical if it is transferred to another lab in 3. If a material synthesized at KSU is transferred out of the University and it is not an article, a MSDS must accompany that material. If an MSDS does not exist, one must be prepared prior to the transfer. The principal investigator is responsible for ensuring that an MSDS is generated and goes with the shipment. MSDS generation should be coordinated with the Manager, Laboratory Safety. 13. Chemical Management{tc "Chemical Management"}
1. An inventory of all chemicals stored in a laboratory will be maintained in the CisPro system. 2. Before any containers of chemicals are stored in a lab, they must be entered into the CisPro 3. Prior to disposal of any original chemical container, the item will be removed from the inventory 4. Chemicals in each laboratory will be inventoried in January of every year. 14. Chemical Storage{tc "Chemical Storage"}
1. Shelves used for chemical storage shall be of substantial construction and adequately braced. Shelves shall be provided with a lip or guard when used for the storage of individual containers, except when containers are stored in a hazardous material storage cabinet. 2. Chemicals must not be stored on shelves more than five feet above the floor. 3. Containers are to be arranged in such a manner as to allow all labels to be seen. When this is impossible, the shelf may be labeled with a list of contents. 4. Chemicals should not be stored on the floor and should not protrude into traffic areas. 5. Materials that are sensitive to light shall be stored in containers designed to protect the contents 6. Food shall not be stored or consumed in areas where toxic chemicals are used or stored. 7. Hallways and stairways should not be used as storage areas. 8. Incompatible chemicals must not be stored together. 15. Flammable Liquid Storage{tc "Flammable Liquid Storage"}
1. Flammable liquids have flash points below 100 F. Combustible liquids have flash point below 140 F. For the purposes of this section, any liquid having a flashpoint below 140 F will be considered to be flammable. 2. All secondary containers of flammables greater than 4 liter shall be of the safety can type meeting 3. Storage of more than 25 gallons of flammable liquids shall be in flammable liquid storage cabinets meeting OSHA or NFPA 30 Flammable Liquid Codes. 4. Flammables shall not be stored in the same cabinet as oxidizers or water-reactive materials. 16. Corrosives Storage{tc "Corrosives Storage"}
1. Corrosives shall not be stored under sinks or in other areas where plumbing, equipment, or shelving could be damaged by corrosive effects. 2. Strong acids (Ph<2) and strong bases (Ph>12.5) shall be stored separately. Where amounts are small, separation can be achieved by either all the acids or all the bases being stored in separate containers such as bottle carriers, spill pans, or other secondary containment. 17. Approvals{tc "Approvals"}
1. Prior approval will be obtained from the appropriate designee for the following: 1. For operations that are to be left unattended. 2. For hazardous operations performed by an individual working alone in a laboratory. 3. For new operations involving pressurized or very exothermic reactions. 2. Approval to continue or proceed will be obtained from the appropriate designee: 1. When there is a failure of equipment, especially safety control measures such as fume hoods, clamp apparatus or temperature control. 2. When the procedure produces unexpected potentially hazardous results. 3. The Department Chair will institute a review mechanism and designate an individual or committee to give approval for the above items. 18. High Hazardous Substance Precautions{tc "High Hazardous Substance Precautions"}
1. This section will apply to laboratory use of chemicals defined as "particularly hazardous substances" in Appendix B of this plan. 2. Departments will establish designated areas for the use of particularly hazardous substances. A designated area may be the entire laboratory, an area of the laboratory, or a fume hood or glove box. High hazard substances shall be limited to designated areas. 3. The location of the designated area shall be posted and persons working within the designated area shall be informed of the hazardous substances used there. A sample posting for designated areas is given in Appendix C. 4. When planning research project and before using a chemical for the first time, always consult the manufacturer’s Material Safety Data Sheet (MSDS) to determine if the material meets the definition of a high hazard chemical. It the material meets the definition, attempt to find a less hazardous substitute material. If a substitute material cannot be found, follow the manufacturer’s recommendations. 5. Storage or consumption of food, storage or use of containers of beverages, storage or application of cosmetics, smoking, storage of smoking materials, tobacco products or other products for chewing, or the chewing of such products, shall be prohibited in designated areas. 6. All high hazard materials should be handled so as to prevent skin contact, accidental ingestion, 7. Use of containment devices and methods for particularly hazardous substances. 1. Containment devices and methods should be used to minimize exposure to persons and to prevent contamination of areas outside the designated area. 2. Use of particularly hazardous substances in a manner that may produce vapors, dusts, mists, particularly hazardous gases or other airborne particulates shall be under a laboratory hood, in a glove box, or in a closed system. 3. Laboratory fume hoods in which other substances are used shall have an average face velocity of 100 linear feet per second, with no area falling below 70 linear feet per second. 4. All mouth pipetting of high hazard chemicals is strictly prohibited. Liquid transfers must be made using pipette bulbs, automatic pipetting devices, or syringes. 5. Work surfaces that may become contaminated with particularly hazardous substances 6. When working with regulated carcinogens, laboratory vacuum systems shall be protected with a double cold trap or with disposable absolute filters. 7. When working with beta-propiolactone, bischloromethyl ether, methyl chloromethyl ether, or ethyleneimine, a double cold trap shall be used. 8. Persons working in the designated area shall remove protective equipment and wash their hands and forearms before engaging in other activities or before eating, drinking, smoking, or using toilet facilities. 9. Appropriate protective gloves should be worn. For most solid materials, latex gloves are adequate. For most liquids, nitrile rubber gloves provide the greatest measure of protection. If there is a question as to the proper glove material for a specific purpose, consult laboratory supervision or the MSDS 8. Procedures for safe removal of contaminated waste. 1. All waste contaminated with particularly hazardous substances should be collected in impervious containers that are compatible with the contaminant. 2. Wastes contaminated with different substances that are incompatible shall not be placed 3. Contaminated sharps, contaminated broken glassware, etc. should be placed in a sturdy container such as a cardboard box and sealed before placing in a collection container. 4. All containers should be labeled with the contaminant(s) and if the contaminant is a carcinogen, the words "Cancer-suspect Agent." 1. Laboratory workers should consider whether or not decontamination of designated areas is appropriate. Decontamination procedures will vary according to the type of substance used. 2. Small spills should be cleaned up immediately and the area decontaminated. 3. All spills that can not be cleaned up by lab employees are to be reported immediately to 10. Special precautions for Reproductive Toxins 1. Women of child bearing age must be apprised of the chemicals in their work area that are known to be embryotoxic and/or affect the reproductive system. Males must also be appraised of the chemicals in their work area that are known to affect the male reproductive system. Documentation of such notification will be maintained by laboratory supervision. 2. All employees who believe they may be pregnant, want to become pregnant or have confirmation of pregnancy should notify their supervisor immediately. Following notification, every effort will be taken by the supervisor and the employee to obtain information about the chemicals being used, processes used and potential chemicals the employee may be exposed to during the pregnancy. The employee with this information will determine in consultation with her physician whether or not to continue to conduct experiments or work with chemicals that may present a risk to the pregnancy. All effort will be taken by the supervisor and KSU to accommodate the recommendations of the physician. 19. Housekeeping, maintenance, and inspections{tc "Housekeeping, maintenance, and inspections"}
1. Laboratories should be kept free of clutter. Working areas should be cleaned up at the end of each operation and at the end of each day. 2. Small spills of chemicals should be cleaned up immediately. Spills that require cleanup measures beyond general housekeeping by laboratory personnel should be reported to DCHO. 3. Safety showers, eyewash fountains, and fire extinguisher shall be free from any obstruction that would prevent access and use. Access to emergency exits shall be kept clear at all times. 4. Circuit breaker panels shall have an unobstructed clearance of 30". 5. The floor shall be kept clean and free of slip hazards by reasonable cleaning and 6. Old containers, compromised containers, and solid chemical wastes should be disposed of promptly and not allowed to accumulate. 2. Inspection and Maintenance of protective devices. 1. Temperature control and over-temperature shutoff devices on heating equipment should be tested in accordance with manufacturer recommendations to ensure proper operation. 2. All automatic shutoff devices should be tested in accordance with manufacturer recommendations to ensure proper operation. 3. Records of inspection and testing of above equipment will be maintained in the 4. Fume hood performance will be evaluated at least annually by Manager, Laboratory 5. Explosion shields and isolation devices should be visually inspected by the user for 6. Safety showers and emergency eyewash fountains will be inspected monthly. Tags indicating date inspected and the inspector's name will be attached on or near the shower or eyewash. 20. Personal Protective Equipment{tc "Personal Protective Equipment"}
1. Each Department will coordinate establishing requirements for PPE and list those requirements in 2. Respirator use will be governed by the KSU Health and Safety Manual. 3. Eye and Face Protection 1. Safety eye protection will be worn at all time in laboratories. 2. Safety goggles (liquid and vapor tight) shall be worn when setting up, taking down or monitoring experiments involving non corrosive chemicals. 3. Face shields shall be worn for any operation involving corrosives. 1. When working with those substances that are readily absorbed by the skin, or with substances that are highly corrosive to the skin, appropriate protection shall be provided by the department to protect the laboratory worker from skin contact. 2. Skin protection may take the form of shields, isolation of the procedure, gloves, aprons, 3. Gloves and aprons should be selected according to the chemical resistance of the protective material to the chemical to be used. This information can be obtained by the supplier of the product and is usually presented in a chemical resistance chart in the supplier's catalog. The Manager, Laboratory Safety should be contacted to assist in selecting the proper personal protective equipment. 21. Medical Consultation and Examinations. {tc "Medical Consultation and Examinations. "}
1. The University shall provide all persons involved in the laboratory use of chemicals an opportunity to receive medical attention, including any follow-up examinations the examining physician determines to be necessary, under the following circumstances: 1. Whenever a laboratory employee develops signs or symptoms associated with a hazardous chemical to which the employee or student may have been exposed in the laboratory: 2. Where industrial hygiene monitoring in a laboratory reveals an exposure level routinely above the action level (or in the absence of an action level, the Permissible Exposure Limit) to a substance listed by OSHA requiring medical examinations; or 3. Whenever an event takes place in the laboratory such as a spill, leak, explosion or other occurrence resulting in the likelihood of a hazardous exposure. 2. Any employee showing signs or symptoms they believe are due to exposure while working in the laboratory must immediately report to the Department Chemical Hygiene Officer who will immediately notify the Manager, Laboratory Safety for determination of need for medical examination. 3. All medical examinations in accordance with this document shall be performed by or under the direct supervision of a licensed physician and shall be provided at no cost to the exposed laboratory employee. 4. The University is required to provide the following to the physician: 1. The identity of the hazardous chemical(s) to which the laboratory employee or laboratory student may have been exposed and a copy of the MSDS, if available; 2. A description of the conditions under which the exposure occurred including quantitative 3. A description of the signs and symptoms of the exposure that the laboratory employee or laboratory student is experiencing, if any. 5. The examining physician will submit to KSU a written statement containing the following. The written statement from the physician may not discuss or reveal any findings that are not specifically related to the occupational exposure to the hazardous chemical(s). 1. Any recommendations for additional medical examinations or follow-up. 2. The results of the medical examination and any tests that were conducted in conjunction with the examination that are specifically related to the exposure and that are not considered medically confidential. 3. Any medical condition uncovered during the course of the examination that may place the employee at increased risk as the result of exposure to the hazardous chemical(s). 4. A statement that the physician has informed the employee of the results of the consultation or examination and of any medical condition that may require further examination or treatment. 22. Laboratory Ventilation{tc "Laboratory Ventilation"}
1. General laboratory ventilation should not be less than four air changes per hour. 2. All local exhaust ventilation systems should be checked every six months to assure they are mechanically operable. During these checks, routine maintenance, as recommended by the manufacturer will also be performed 3. Any employee who has reason to believe that a local exhaust ventilation system is not functioning properly, shall immediately report the suspected problem to their supervisor and DCHO. The Supervisor will request, via a work order, that the Physical Plant Services Department inspect the system to assure that it is operating properly. 4. All local exhaust ventilation systems shall be checked every six months to assure that there is adequate air flow. Fume hoods should have a minimum face velocity of 80 linear feet per minute with the sash in the position it will be kept during normal operations. 5. Records of all measurements made to check the operability and adequacy of laboratory exhaust ventilation systems will be maintained in the Physical Plant Services Department. 6. Laboratory personnel must recognize and be aware that: 1. Laboratory fume hoods are a backup for other safety devices such as traps and 2. All equipment used in a fume hood should be kept at least six inches from the front edge. 3. All equipment must be effectively secured to prevent it from being inadvertently knocked 4. Fume hood doors must be kept in a position that will provide an adequate air flow while reactions or procedures are being conducted. 5. Fume hood fans should be left running whenever there are chemicals present in the hood, regardless of whether or not a procedure is being performed. 6. Fume hoods should not be used to store chemicals or apparatus. 7. Personnel must be aware of procedures to follow if the power to a local exhaust 23. Records{tc "Records"}
1. Records documenting training will be kept for length of employment plus 30 years by the 2. Records of audits or inspections will be kept for 5 years by the department conducting the audit. 24. Corrective Actions{tc "Corrective Actions"}
1. Compliance with procedure will be evaluated during audits and laboratory visits by Manager, Laboratory Safety and Department Chemical Hygiene Officer. Appendix A: Standard Laboratory Procedures{tc "Appendix A
1. Standard Laboratory Procedures"}
1. Compressed Gases {tc "Compressed Gases " \l 2}
1. Compressed gases should not be transferred from one container to another except by the manufacturer or distributor. Exception - refilling SCBAs from breathable air cylinders by authorized personnel. 2. Containers shall be legibly marked to identify the contents and give the appropriate precautionary 3. Containers shall be stored upright and secured, with caps on when not being used. Combustible material or formed metal chains are not recommended to secure cylinders. Chains or other securing mechanisms should be located between one-third and two-thirds of the height of the container. 4. Oxygen and oxidizing gases shall be stored separately from flammable and highly combustible material. 5. Pressure reducing regulators should be used when withdrawing contents from the cylinder. 6. Valve outlets and pressure relief valves should be directed away from personnel at all times. 7. Valves on cylinders being moved, cylinders that are not in use, or on empty cylinders shall be closed and 8. Do not exchange regulators or other appliances used with one gas with similar equipment used with other gases. Oils and lubricants should not be used on fittings for oxygen or other oxidizing gases. 9. Do not force connections that do not fit. 10. Use transport dollies to move cylinders.
2. Cryogenic Materials {tc "Cryogenic Materials " \l 2}
1. The primary hazard of cryogenic materials is their extreme coldness. They and all surfaces they cool can cause severe burns if allowed to contact the skin. 2. Cryogenic fluids shall be stored or handled only in containers designed for such use. 3. When personal contact with a cryogenic fluid is possible, (as when preparing cold baths or dispensing liquid nitrogen) full face shields should be worn. Wearing of watches, rings, or other items that may trap the cryogenic material should be avoided. 4. When gloves are worn while handling cryogenic materials, they should be dry, impervious and loose enough to be easily tossed off the hands. 5. Lab coats should be worn over shorts and short skirts while handling cryogenic materials. Open toe shoes 6. Cryogenic materials should be dispensed and used in areas with good ventilation. Laboratory workers should avoid lowering their head into dry ice chests or directly over cooling baths. When transporting dry ice, or materials packaged in dry ice, the package should not be carried in the passenger compartment of the vehicle. 7. Cryogenic material may provide an oxygen enriched atmosphere by condensing and fractionating air. This situation may increase the fire and explosion hazard of flammable and combustible materials being cooled or materials located in the vicinity of the operation. 8. Dry ice should be added to cooling baths (or liquid added to dry ice) in small increments, allowing the 3. Peroxidizable Materials {tc "Peroxidizable Materials " \l 2}
1. Peroxidizable materials should be purchased in amounts that are expected to be used within six months to one year. This practice will help ensure that others are used up before the manufacturer's expiration date. 2. Peroxidizables, either opened or unopened, should be disposed of or tested for peroxides upon reaching the manufacturer's expiration date, or upon one year after receipt. If positive for peroxides, the peroxides may be removed or the materials may be disposed of by submitting a "Request for Chemical Pick-up" to Chemical Hygiene Officer. Please be sure to label the date that the test for peroxides was performed and the date peroxides removed (if applicable). The new expiration date will be three months after the date tested for materials in List A, and one year after the date tested for materials in List B. 3. Containers should be marked with the date opened and, in the absence of a manufacturer's expiration date, with the date received. Containers should also be marked with the date that the last test for peroxides was done. 4. Ethers should be disposed of without opening if there are visible crystals around the cap, or if the container is in a grossly corroded condition. Crystals visible in the container should be brought to the attention of the instructor, principal investigator or staff research assistant. 5. Leave at least 10 percent bottoms when distilling peroxidizables. The flask can be rinsed with equal amounts of a solvent such as ethanol and considered as waste. 6. Test for peroxides before distilling (even previously unopened ethers) and upon three months after opening List A and after one year of opening List B materials: 1. Isopropyl ether; Divinyl acetylene; Vinylidene chloride; Potassium 1. Isopropyl ether; Diethyl ether; Divinyl acetylene; Tetrahydrofuran; Vinylidene 2. Decahydronaphthalene (Decalin); Tetrahydronaphthalene (Tetralin) 3. Ethylene glycol dimethyl ether; Cyclohexene; Vinyl ethers 4. Diethylene glycol dimethyl ether; Dicyclopentadiene 4. Perchloric Acid {tc "Perchloric Acid " \l 2}
1. Use goggles for eye protection whenever the acid is handled 2. In wet combustion with perchloric acid, treat the sample first with nitric acid to destroy easily oxidizable 3. Any procedure involving heating of the perchloric acid should be conducted in a ventilated hood equipped 4. Perchloric acid hoods should be constructed of materials that are acid resistant, non-reactive and impervious to perchloric acid, such as stainless steel. 5. Organic material should not be stored in the perchloric hood. 6. Do not allow perchloric acid to come in contact with strong dehydrating agents (concentrated sulfuric acid, 7. Perchloric acid should be used only in standard analytical procedures from well recognized analytical texts. Researchers should take the properties and hazards of perchloric acid into consideration before use. 8. If a laboratory hood or exhaust system has been exposed to perchloric acid heated above ambient temperature, tests should be conducted for explosive perchlorates before any inspection, cleaning, maintenance, or any other work is done on any part of the exhaust system or hood interior. 5. Electrical Equipment {tc "Electrical Equipment " \l 2}
1. Extension cords shall not be used as permanent wiring. Power strips that are equipped with an over current protection device (circuit breaker) may be used. A power strip will not be plugged into another power strip. 2. Electrical receptacles must not rest on laboratory bench tops. 3. Power cords on appliances should be inspected for damage regularly. Frayed or otherwise damaged cords should be replaced before using. 4. To eliminate exposed wiring, outlet boxes or junction boxes shall be provided with coverplates and receptacles shall be provided with faceplates. 5. Ground-fault circuit interrupters should be used over sinks and in other wet areas. Ground-fault circuit interrupters should be actuated every six months to insure proper function. 6. Over current protection devices (circuit breakers) on panes shall be individual labeled to indicated the equipment or location of equipment served by the device. 1. Laboratory refrigerators used for storing or cooling flammable liquids will be in compliance with NFPA 45 - Fire Protection for Laboratories Using Chemicals, section 9.2.2.2 and A.9.2.2.2. 2. All refrigerators will be appropriately labeled for the storage of chemicals, flammables or food. 1. Unattended electrical heating equipment should be provided with a manual reset over-temperature shutoff switch, in addition to normal temperature controls. 2. While air powered mixers are preferred, electric motors may be used to drive blenders or stirrers in open containers of flammable liquids or combustible liquids heated above their flash points provided they meet Class I, Division 2 locations as defined in Article 500-5 of the National 3. Electrical equipment and apparatus in cold rooms should be protected from moisture due to 4. All apparatus use in the laboratory must be approved by a recognized approval agency (UP, ASTM, etc) or meet accepted NFPA or ANSI standards. 1. Only experienced researchers who have been trained to work safely with test instruments and equipment on energized circuits may remove enclosures and guards to perform testing on energized electrical circuits. 6. Working Alone {tc "Working Alone " \l 2}
1. Working with hazardous chemicals alone, especially after regular hours in a laboratory, poses an additional risk to life and property. If an unanticipated event occurs and the researcher is incapacitated, available safety equipment, such as emergency showers, fire extinguishers, or antidotes, become worthless to provide emergency assistance to injured individuals or to mitigate the losses incurred. 2. Each Department Chemical Hygiene Plan needs to incorporate a working alone procedure suited to the 3. Some provisions that may be incorporated or adapted into individual or Department Chemical Hygiene 1. Prohibiting working alone in laboratories, or prohibiting working alone for certain procedures. 2. Buddy system 3. Arrange with someone working nearby to periodically check on one another 4. Arrange to take scheduled breaks with another researcher working nearby. 5. Arrange to periodically check in with another person 6. Remote monitoring by CCTV 7. Unattended Operations {tc "Unattended Operations " \l 2}
1. Unattended electrical heating equipment should be provided with a manual reset over-temperature shutoff switch, in addition to normal temperature controls. 2. Unattended operations that depend on a flowing cooling water supply should be provided with a manual reset shutoff device that will shut off the heat supply upon loss of cooling water. 3. Arrangements should be made, where possible, to periodically check unattended operations for abnormal 4. For operations left running after normal hours, leave the lights on and leave a sign on the door indicating that an unattended procedure is in progress. The sign should also give emergency phone numbers in case of incident. 8. Glassware {tc "Glassware " \l 2}
1. Accidents involving glassware are a leading cause of laboratory injuries. 2. Careful handling and storage procedures should be used to avoid damaging glassware. Damaged items 3. Adequate hand protection should be used when inserting glass tubing into rubber stoppers or corks or when placing rubber tubing on glass hose connections. Tubing should be fire polished or rounded and lubricated, and hands should be held close together to limit movement of glass should fracture occur. The use of plastic or metal connectors should be considered. 4. Glass blowing services are provided by Chemistry Department, contact Diane Skok ext. 3900. 5. Vacuum-jacketed glass apparatus should be handled with extreme care to prevent implosions. Equipment such as Dewar flasks should be taped or shielded. Only glassware designed for vacuum work should be used for that purpose. 6. Hand protection should be used when picking up broken glass. (Small pieces should be swept up with a 7. Proper instruction should be provided in the use of glass equipment designed for specialized tasks, which can represent unusual risks for the first time user. (For example, separatory funnels containing volatile solvents can develop considerable pressure during use). 9. Laboratory (Fume) Hood Usage {tc "Laboratory (Fume) Hood Usage " \l 2}
1. The Department Chemical Hygiene Officer and Manager, Laboratory Safety will periodically inspect laboratory hoods to determine proper function and adequate face velocity. The following are considerations for the laboratory hood users that will facilitate optimum hood performance. 2. Manager, Laboratory Safety should be consulted for new hood installation. 3. Laboratory hoods should not be relied upon to provide explosion (blast) protection unless specifically 4. When perchloric acid is evaporated or heated above ambient temperatures in a laboratory hood, the hood should be specifically designed for perchloric acid. 5. For new installations or modifications of existing installations, fixed electrical services and their controls should be located external to the hood and within easy reach. 6. For new installations of modifications of existing installations, controls for other services (gas, air, water, etc.) should be located external to the hood and within easy reach. 7. Sash openings should be kept to a minimum. 8. Chemicals and apparatus should be located within the hood and should be kept at least six inches behind 9. Personnel should keep their faces outside the plane of the sash. 10. Storage in hoods should be kept to an absolute minimum. Appendix B: High Hazardous Substances{tc "Appendix B
High Hazardous Substances"}
High hazardous substances - these include "regulated and select carcinogens," "reproductive toxins," and "substances with a high degree of acute toxicity." 1 Regulated carcinogen - any of the following substances or any substance containing more than 0.01% of the substances OSHA has determined to be carcinogenic. Select carcinogen - any substance that meets one of the following criteria: a. Any substance regulated by OSHA as a carcinogen b. Any substance listed by the NTP as "Known to be Carcinogenic". c. Any substance listed as a Group I carcinogen by the IARC. d. Any Group 2A or 2B IARC substance or NTP "Reasonably Anticipated to be Carcinogenic" substance that produces a statistically significant tumor incidence under the following criteria: i. Lifetime inhalation exposure at <10 mg/M3. ii. Repeated skin applications of <300 mg/Kg/week. iii. Repeated oral doses of <50 mg/Kg/day. iv. The specifics of what "repeated" means in Items 2 & 3 above are not spelled out in 29 CFR 1910.1450, thus discretion will be used in determining the applicability of these definitions. bis)chloromethyl) ether and chloromethyl methyl ether (technical grade) 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea (methyl CCNU) hexachlorocyclohexane y-hexachlorocyclohexane b-hexachlorocyclohexane melphalan 8-methoxypsoralen(methoxsalen) with Ultraviolet A therapy (PUVA) IARC, NTP 2-methylaziridine(propyleneimine) 4,4-methylenebis(N,N-dimethyl) benzenamide (Michler's base) 4,4-methylenebis(2-chloroaniline)(MBOCA) OSHA, 4,4-methylenedianiline and its dihydrochloride Mineral oils, untreated and mildly treated MOPP (combined therapy with nitrogen mustard, vincristine, procarbazine and prednisone) and other combined chemotherapy including 5-nitro-o-anisidine NTP N-nitrosodiethylamine N-nitrosomethylvinylamine NTP N-nitrosomorpholine N-nitrosodi-N-propylamine NTP N-nitrosodiethanolamine benz(a)anthracene benzo(b)fluoranthene benzo(j)fluoranthene benzo(k)fluroanthene benzo(a) dibenz(a,j)acridine dibenz(a,h)anthracene 7H dibenzo(a,e)pyrene dibenzo)a,h)pyrene dibenzo(a,i)pyrene dibenzo(a,l)pyrene indeno(1,2,3-cd)pyrene 5-methylchrysene phenacetin 2,3,7,8-tetrachlorodi-benzo-p-dioxin(TCDD) NTP tetrachloroethylene(perchloroethylene) 3. Reproductive toxins - Reproductive toxins are chemicals or other hazards that may manifest themselves in lethal effects on the fertilized egg, developing embryo or fetus or have teratogenic effects in the fetus. In addition, certain reproductive toxins may cause infertility in males and females. The following is a list of chemicals that have been found to have at least one of the above effects. [Source: Zenz, Occupational Medicine, Second Edition, Yearbook Medical Publishers, 1988.] Fetal effects may include: spontaneous abortion, low birth weight, still births, neonatal deaths, congenital anomalies and behavioral or developmental disabilities. Decreased fertility may include both male and female fertility disorders. Chemicals that affect the reproductive capabilities including chromosomal damage (mutations) and effects of fetuses (teratogenesis). 4. Highly Toxic Material. Check MSDS of chemical substance under consideration for toxicity status. a. A material that has an oral LD50 of # 50 mg/Kg when administered to albino white rats that weigh between b. A material that has a dermal LD50 of # 200 mg/Kg in 24 hours or less when applied to the bare skin of albino rabbits that weigh between two and three kilograms. c. A material that has an inhalation LC50 of # 200 ppm or 2 mg/M3 in one hour or less when administered to albino rats that weigh between 200 and 300 grams. Appendix C Sample Posting for Designated Areas{tc "Appendix C
Appendix D Definitions{tc "Appendix D
and University Chemical Hygiene Officer. A written document that details how Kent State University will manage the hazardous chemicals that are present and used in its laboratories. The individual who has responsibility for administering a particular department's Chemical Hygiene Plan. A written program developed and instituted by in order to comply with the OSHA Hazard Communication Standard (29 CFR 1910.1200). This program sets forth the policies and procedures regarding Material Safety Data Sheets, container labeling, and employee training. The Director of Occupational Health and Safety in the Office of Risk Management. The administrator has overall management responsibility for the establishment of practices and procedures to implement the Hazard Communication Program. Any chemical that may present a physical hazard or a health hazard. A chemical for which there is statistically significant evidence that acute or chronic health effects Material Identification System. A labeling and hazard rating system developed by the National Paint and Coatings Association. Any written, printed or graphic sign or symbol displayed on or affixed to containers of hazardous chemicals. A label should identify the hazardous material, appropriate hazard warnings, and name and address of the manufacturer or other responsible party. Material Safety Data Sheet. Developed and provided by the chemical manufacturer to inform employers of the properties and hazards of the chemical. A task that is conducted on an infrequent or non-routine basis that involves the potential exposure to hazardous chemicals (i.e., tank cleaning). Safety and Health Administration. OSHA is part of the Department of Labor and is the regulatory and enforcement agency for safety and health in the industrial sector. A chemical that is a combustible liquid, a compressed gas, explosive, flammable, an organic peroxide, an oxidizer, pyrophoric, unstable (reactive), or water-reactive. The individual in the Research and Graduate Studies Division who has been designated as the Manager, Laboratory Safety. This individual is charged with the overall administration of the university's compliance with OSHA's Laboratory Safety Standard. Appendix E: Laboratory Inspection Report{tc "Appendix E
Laboratory Inspection Report"}
Department ___________________________________________ Date _________________________ CHO ______________________________________________________________________________ Inspector (Print) _____________________________(Sign)____________________________________ Building________________________Room(s)______________________________________________ SA NI Work area separated from study/social areas Laboratory Hygiene Plan written and available, including Lab specific Written Standard Operating Procedures Lab specific Material Data Sheets Available Emergency response and evacuation plan posted good condition, preventive maintenance plan in place Exit ways are clear of slip, trip and fall hazards Doorways are unobstructed and door is usable as an exit Class ABC fire extinguisher in laboratory, near door or on path of egress Fire extinguishers are unobstructed and have been serviced yearly Trash and combustible materials are removed on a regular basis are limited to less than 25 gallons for each laboratory, or are stored in approved flammable cabinets Refrigerators used for flammables are flammable material storage units or explosion proof. Flammables not stored along path of egress Floor areas are free of debris, spilled liquid and tripping hazards A minimum of 24 inches of aisle spaces are maintained Equipment not placed so as to create a hazard Food is consumed or stored only in areas where no toxic chemicals and/or radioactive materials are stored or used. No circuits overloaded with extensions cords or multiple connection Extension cords not used for permanent wiring Apparatus equipped with three-pronged plugs or double insulated electrical heating equipment is provided with manual reset automatic shutoff Automatic shutoff devices (when present) have been tested and are functioning properly flammable vapors may be present, are listed for the Heating apparatus equipped with redundant temperature controls Circuits, equipment provided with ground-fault interrupters as needed Shelves used for chemical storage are sturdy, well braced and have a guard. All containers of hazardous substances are properly labeled. firmly into place, cylinders not in use capped, oxidizing and reducing gasses segregated Flammables and oxidizers are stored separately Strong acids and strong bases are separated either in separate cabinets or in separate containment within a cabinet. Peroxidizable materials have not reached the manufacturers expiration date, or test negative for peroxides and the new expiration date is clearly marked on the container. Leaking containers have been repaired, replaced or properly disposed of. Containers for collecting used hazardous materials are properly labeled and kept closed. All work generating toxic and hazardous fumes done in hoods Work capable of causing an explosion behind protective barriers, vacuum vessels taped, etc. Chemicals not stored over 7 feet off of floor so as to not create a hazard. The material is stacked, blocked or otherwise secured against sliding or collapse. Employees are trained in and practice safe lifting techniques. guarded at their point of operation and have power transfer and other moving parts guarded or have some other means or method that provides equivalent protection to the operator(s) and other employees in the vicinity. shields are in place and have been maintained to be functionally as effective as they were when new or they are effective in satisfying the guarding requirements of OSHA . Refrigerators in laboratories are marked to indicate whether they are explosion proof, modified or non-explosion proof. Glassware used for vacuum work is designed for such work. inspected within the last year and are so marked. There is a visual indicator that shows the hood is operating. Storage in fume hood is kept to an absolute minimum. Fume generating apparatus kept 6 inches behind the vertical plane of the sash. Evaporation or heating of perchloric acid is done only in a hood specifically designed for perchloric acid. Laboratory at negative pressure with respect to corridors Hoods located in low traffic draft-free zones Hoods capable of maintaining 85-100 fpm face velocity with sash at normal use position Hoods not used for storage of surplus materials All required Personal Protective Equipment (PPE) is available, in good repair and personnel are trained in its use Appropriate gloves to protect chemicals, hot or cold objects or against nicks and cuts. Appropriate aprons, coveralls and/or rain gear available to protect employees from splashes or other exposure to hazardous materials. glasses, goggles, face shields, etc.) available to protect against splashing or flying objects. available to reduce noise levels to below the Appropriate respiratory protective equipment (Prescribed, fit tested and issued by EH&S) available for use against dust, mists, fumes and gasses. Eyewash station available, checked at least semiannually where corrosive or other eye or face hazards are present Deluge shower available, checked at least semiannually First aid kit available and fully maintained _________________________________________________________________ _________________________________________________________________ _________________________________________________________________ _________________________________________________________________ SA = Satisfactory NI = Needs Improvement Explanation of University Chemical Hygiene Plan Location of University and Departmental Chemical Hygiene Plans Hazards of Chemicals Unique to the Laboratory Special Hazard Controls and Safety Procedure for the Laboratory Location of Emergency Equipment (Eyewash fountains, Safety Showers, First Aid Supplies, Location and Use of Personal Protective Equipment (Gloves, Eye and Face Protection, Explosion Shields, etc.) Chemical Hazards and Understanding the MSDS Appendix G: Record of Laboratory Safety Meeting{tc "Appendix G
Record of Laboratory Safety Meeting"}
What was the topic? What visual aid were used? What was handed out? What questions or concerns were expressed that need following up? Complete for each meeting and send to Department Chemical Hygiene Officer.

Source: http://www.dept.kent.edu/ors/ORSContent/ORSChem/KSUCHP.pdf