Date de naissance : 06/05/1952 claude.vaccher@univ-lille2.fr Groupe de Recherche Interdisciplinaire Innovation et Optimisation Thérapeutique UNIVERSITE LILLE 2 Enseignant-chercheur: Professeur des Universités 1ère C
Section du CNU : 85
- Ingénieur-Chimiste (LILLE 1) 1976 - Docteur-Ingénieur (LILLE 1) 1981 - Diplôme d'Etat de Docteur en Pharmacie (LILLE 2) 1988 - Habilitation à Diriger des Recherches (LILLE 2) 1993 - Prime d’Encadrement Doctoral et de Recherche depuis 1990 (5ème contrat) 1) Points forts des activités de recherche: Thèmes de recherche développés ; -Ligands des récepteurs de la mélatonine -Ligands des récepteurs du GABA -Anticancéreux (Inhibiteurs de topoisomérase I, inhibiteurs d’aromatase) -Antiviraux (nucléosides, VIH) Etude rationnelle des séparations analytiques et préparatives de molécules potentiellement actives ou avérées, présentant des centres de chiralité -Méthodologies séparatives (CLHP et EC) et spectroscopiques (RMN, SM) Applications à l’étude de molécules chirale -Aspects fondamentaux de la chiralité ; étude des mécanismes de discrimination chirale. 2) Production scientifique : A]-128 PUBLICATIONS PARUES/ACCEPTEES dans Revues Internationales B]-3 Brevets US C]-3 Publications Nationales D]-60 Communications-Posters Liste des quatre dernières années -Enantioselective analysis of the antipsychotic 9-hydroxyrisperidone, main metabolite of risperidone, by chiral capillary electrokinetic chromatography using dual cyclodextrins. C. DANEL, P. CHAMINADE, P. ODOU, C. BARTHELEMY, D. AZARZAR, J.P. BONTE, C. VACCHER Electrophoresis - (2007) 28(15), 2683-2692 -Determination of pKa values of benzoxa-, benzothia- and benzoselena-zolinone derivatives from mobility obtained by capillary electrophoresis. Comparison with potentiometric titration and spectroscopic data. C. FOULON, N. DUHAL, B. LACROIX-CALLENS, C. VACCHER, J.P. BONTE, J.F. GOOSSENS European Journal of Pharmaceutical Sciences - (2007) 31, 165-171 -P-glycoprotein and cytochromeP4503A4 involvement in risperidone transport using an in vitro Caco2/TC7 model and an in vivo model E. COUSEIN, C. BARTHELEMY, S. POULLAIN, N. SIMON, S. LESTAVEL, V. WILLIAME, E. JOIRIS, C. DANEL, C. VACCHER, V. CLAVEYS, D. BROSSARD, H. ROBERT, S. CRAUSTE-MANCIET, P. ODOU Progress in Neuropsychopharmacology and Biological Psychiatry - (2007) 31(4), 878-886. -Chiral resolution of six melatoninergic ligands, by electrokinetic chromatography using highly sulfated cyclodextrins E. LIPKA, C. DANEL, H. ORHAN, J.P. BONTE, C. VACCHER Electrophoresis - (2007) 28(21), 3915-3921 -Analytical and semipreparative enantioresolution of 9-hydroxyrisperidone, main metabolite of risperidone using high performance liquid chromatography and capillary zone electrophoresis. Validation and determination of enantiomeric purity C. DANEL, P. ODOU, C. BARTHELEMY, D. AZARZAR, H. ROBERT, J.P. BONTE, C. VACCHER Journal of Chromatography A - (2007) 1163(1-2), 226-236 -Chiral resolution of the enantiomers of new selective CB2 receptor agonists by liquid chromatography on amylose stationary phases E. STERN, L. GOOSSENS, C. VACCHER, J-P. BONTE, P. DEPREUX, J-P. HENICHART, J-F. GOOSSENS Journal of Pharmaceutical and Biomedical Analysis - (2008) 46(5), 848-853 -Preparative Enantiomeric Separation of Potent AMP-Activated Protein Kinase Activator by HPLC on Amylose-Based Chiral Stationary Phase. Determination of Enantiomeric Purity and Assignment of Absolute Configuration
M.P. VACCHER, J. CHARTON, A. GUELZIM, D.H. CAIGNARD, J.P. BONTE, C. VACCHER Journal of Pharmaceutical and Biomedical Analysis - (2008) 46(5), 920-928 -Chiral separation of nucleoside phosphoramidates diastereoisomers by high performance liquid chromatography and capillary electrophoresis. JF. GOOSSENS, VILLARD AL., PERIGAUD C., BONTE JP., VACCHER C., FOULON C. Journal of Chromatography B – (2008) 875, 288-295 -LC using two different cellulose polysaccharide chiral stationary phases for direct enantioseparation of benzoxazolinone aminoalcohols and aminoketones. E. LIPKA, C. VACCHER, J.P. BONTE Chromatographia - (2008) 68, 1053-1057 -Risperidone and 9-hydroxyrisperidone : study of the complexation with cyclodextrin-hosts using affinity capillary electrophoresis and 1H NMR. C. DANEL, N. AZAROUAL, A. BRUNEL, D. LANNOY, P. ODOU, G. VERMEERSCH, C. VACCHER Journal of Chromatography A - (2008) 1205 (1), 185-193 -Enantiomeric resolution of benzoxazolinone amino alcohols, potential adrenergic ligands, by LC and CE. E. LIPKA, C. VACCHER, J.P. BONTE Chromatographia - (2009) 69, 465-472 -Semipreparative enantioseparation of benzoxazolinone aminoalcohols and their aminoketon precursors, potential adrenergic ligands, by liquid chromatography on amylose chiral stationary phases. Caracterisation of the enantiomers. E. LIPKA, C. VACCHER, J.P. BONTE Chirality - (2009) 21, 769-776 -Capillary Electrophoresis and High Performance Liquid Chromatography for Chiral Separation of Four Piperidinic Benzoxazolinone Compounds. E. LIPKA, C. VACCHER, J.P. BONTE, C. FOULON Chromatographia - (2009) 69, 903-909 -Tic-hydantoine 1 agonist:, pharmacological characterization on cocaine induced stimulant and appetitive effects. TOUSSAINT M., DELAIR B., FOULON C., LEMPEREUR N., VACCHER C., MAURICE C., MELNYK P. European Neuropsychopharmacology (2009) 19, 504-515 -Enantioseparation of chiral benzimidazole derivatives by electrokinetic chromatography using sulfated cyclodextrins. E. LIPKA, J. CHARTON, M.P. VACCHER, M. FOLLY-KLAN, J.P. BONTE, C. VACCHER Journal of Separation Science - (2009), 32(11), 1907-1915 -Chiral stability of the 9-hydroxyrisperidone. Kinetics and mechanism of racemization C. DANEL, N. AZAROUAL, D. LANNOY, A. BRUNEL, P. ODOU, B. DECAUDIN, G. VERMEERSCH, J-P. BONTE, C. VACCHER Tetrahedron Asymmetry - (2009) 20(10), 1125-1131 -Separation of diastereoisomers of Ara-C phosphotriesters using solid phase extractionand HPLC for the study of their decomposition kinetic in cell extracts. C. FOULON, J. TEDOU, S. PEYROTTES, PERIGAUD C., BONTE J-P., C. VACCHER, J.F. GOOSSENS Journal of Chromatography B – (2009) 877, 3475-3481 -Assessment of the complexation degree of camptothecin derivatives and cyclodextrins using spectroscopic and separatives methodologies C. FOULON, J. TEDOU, T. QUERUAU LAMERIE, C. VACCHER, BONTE J-P., J.F. GOOSSENS Tetrahedron Asymmetry - (2009), 20, 2482-2489
-Chiral capillary electrophoresis with highly sulfated cyclodextrins. Resolution of benzoxazolinone aminoalcohols and aminoketon precursors, potential adrenergic ligands. E. LIPKA, M.P. VACCHER, J-P. BONTE, C. VACCHER Analytical Letters - (2010), 43(15), 2356-2371
-Sigma-1 ligands : Tic-Hydantoin as a key pharmacophore TOUSSAINT M., MOUSSET M., FOULON C., JACQUEMARD U., VACCHER C., MELNYK P. European Journal of Medicinal Chemistry - (2010), 45(1), 256-263
-Unambiguous structure elucidation of the reaction products of aryl β-diketoesters with hydroxylamine V. ANDRZEJAK, J.EL BAKALI, A. GUELZIM, J.P. BONTE, S. GLUSZOK, P. CHAVATTE, R. MILLET, C. VACCHER, E. LIPKA Letters in Organic Chemistry- (2010), 7(1), 32-38
-Dual cyclodextrin system in capillary electrophoresis for direct separation of the four stereoisomers of agonist and antagonist melatoninergic ligands. » E. LIPKA, C. DANEL, S. YOUS, J.P BONTE, C. VACCHER Electrophoresis - (2010) 31(9), 1529-1532 -Separation of Tic-hydantoin enantiomers, potent sigma-1 agonist, by high performance liquid chromatography and capillary electrophoresis. AC. CARBODERY, M; TOUSSAINT, JP; BONTE, P. MELNYK, C. VACCHER, C. FOULON Journal of Chromatography A - (2010) 1217(24), 3871-3875
-Determination of pKa values of benzimidazole derivatives, potent AMPK activators, by capillary electrophoresis E. LIPKA, M. FOLLY-KLAN, M.P VACCHER, J. CHARTON, J.P BONTE, C. VACCHER Journal of Pharmaceutical and Biomedical Analysis - (2010) 53, 1267-1271
-Kinetics and mechanism of racemization of Tic-hydantoins, potent sigma-1 agonists A.C. CABORDERY, M. TOUSSAINT, N. AZAROUAL, J.P. BONTE, P. MELNYK, C. VACCHER, C. FOULON
Tetrahedron Asymmetry - (2011) ACCEPTEE 3) Points forts des activités autres que la recherche : - ENCADREMENT
-stagiaires du Diplôme Universitaire d’Etudes Pratiques et Théoriques en Sciences
du Médicament et Sciences Biologiques de L’Université de Lille 2, de stagiaires BTS, DUT de Chimie, de Master 1 et 2 et de Mastere Encadrement de
-Thèses au sein de l’EA 4034 avec publications
- ADMINISTRATION
-Membre suppléant élu de la Commission de Spécialistes de 39ème section de l’Université de Lille2 -Membre suppléant nommé de la Commission de Spécialistes des 39, 40 et 41 èmes sections de l’Université d’Amiens -Membre élu du Conseil d’Administration de la Faculté de Pharmacie -Responsable de l’EA 4034 : Groupe de Recherche Analyse du Médicament
- COOPÉRATIONS INDUSTRIELLES ET VALORISATION
-Contrat Ligue Contre le Cancer, comité Nord 2004-2006 Intervenant du projet intitulé : « anticancéreux à activité énantiosélective »
-Contrat Industriel Société DORANInternational (Lyon)(Promoteur) ESSAI CLINIQUE ONCOPERF01
Titre du Projet : « Evaluation de l’impact du dispositif médical d’administration parentérale d’une chimiothérapie anticancéreuse sur les paramètres pharmacocinétiques » -Contrat ANR (collaboration)
NEUROSCIENCES (Alzheimer) Contrat de RECHERCHE ANR -07-EMPB-034-03 TherAlz - INFORMATION SCIENTIFIQUE & TECHNIQUE ET VULGARISATION :
-Rapporteur dans les périodiques : Journal of Chromatography A, Journal of Chromatography B, Electrophoresis, Analytica Chimica Acta, Talanta, Journal of Pharmaceutical and Biomedical Analysis, Journal of Separation Science, Chirality.
- ENSEIGNEMENTS
Enseignements de chimie analytique en 1er, 2ème et 3ème cycles des études pharmaceutiques Encadrement de :stagiaires du Diplôme Universitaire d’Etudes Pratiques et Théoriques en Sciences du Médicament et Sciences Biologiques de L’Université de Lille 2, de stagiaires BTS, DUT de Chimie, de Master 1 et 2 et de Mastere
nausea and vomitingRudolph M. Navari, MD, PhDIndiana University School of Medicine–South Bend, South Bend, INNausea and vomiting associated with cancer chemotherapy are experienced by 70%–80% of patients receiving chemotherapy and can result in significant morbidity. Chemotherapy-induced nausea and vomiting (CINV) adversely affects patient quality of life, often leading to poor compliance
2ND YEAR RESEARCH ELECTIVE RESIDENT’S JOURNAL Randomized, Placebo-Controlled, Double Blinded Clinical Trial of Bupropion (*Wellbutrin) vs. Venlafaxine (*Effexor) for the Treatment of Hot Flashes in Men undergoing Androgen Ablation Therapy for Prostate Cancer Andrew B. Brown A. Study Purpose and Rationale Hot Flashes pose a significant clinical problem worldwide in men who are