Fiche web cv


Date de naissance : 06/05/1952
claude.vaccher@univ-lille2.fr
Groupe de Recherche Interdisciplinaire Innovation et Optimisation Thérapeutique
UNIVERSITE LILLE
2
Enseignant-chercheur
: Professeur des Universités 1ère C
Section du CNU : 85

- Ingénieur-Chimiste (LILLE 1) 1976
- Docteur-Ingénieur
(LILLE 1) 1981
- Diplôme d'Etat de Docteur en Pharmacie (LILLE 2) 1988
- Habilitation à Diriger des Recherches (LILLE 2) 1993
- Prime d’Encadrement Doctoral et de Recherche depuis 1990 (5ème contrat)
1) Points forts des activités de recherche:
Thèmes de recherche développés ;
-Ligands des récepteurs de la mélatonine
-Ligands des récepteurs du GABA
-Anticancéreux (Inhibiteurs de topoisomérase I, inhibiteurs d’aromatase)
-Antiviraux (nucléosides, VIH)
Etude rationnelle des séparations analytiques et préparatives de molécules potentiellement actives ou
avérées, présentant des centres de chiralité
-Méthodologies séparatives (CLHP et EC) et spectroscopiques (RMN, SM)
Applications à l’étude de molécules chirale
-Aspects fondamentaux de la chiralité ; étude des mécanismes de discrimination chirale.
2) Production scientifique :
A]-128 PUBLICATIONS PARUES/ACCEPTEES dans Revues Internationales
B]-3 Brevets US
C]-3 Publications Nationales
D]-60 Communications-Posters
Liste des quatre dernières années

-Enantioselective analysis of the antipsychotic 9-hydroxyrisperidone, main metabolite of risperidone, by
chiral capillary electrokinetic chromatography using dual cyclodextrins.
C. DANEL, P. CHAMINADE, P. ODOU, C. BARTHELEMY, D. AZARZAR, J.P. BONTE, C. VACCHER
Electrophoresis - (2007) 28(15), 2683-2692
-Determination of pKa values of benzoxa-, benzothia- and benzoselena-zolinone derivatives from mobility
obtained by capillary electrophoresis. Comparison with potentiometric titration and spectroscopic data.
C. FOULON, N. DUHAL, B. LACROIX-CALLENS, C. VACCHER, J.P. BONTE, J.F. GOOSSENS
European Journal of Pharmaceutical Sciences - (2007) 31, 165-171
-P-glycoprotein and cytochromeP4503A4 involvement in risperidone transport using an in vitro Caco2/TC7
model and an in vivo model
E. COUSEIN, C. BARTHELEMY, S. POULLAIN, N. SIMON, S. LESTAVEL, V. WILLIAME, E. JOIRIS, C.
DANEL, C. VACCHER, V. CLAVEYS, D. BROSSARD, H. ROBERT, S. CRAUSTE-MANCIET, P. ODOU
Progress in Neuropsychopharmacology and Biological Psychiatry - (2007) 31(4), 878-886.
-Chiral resolution of six melatoninergic ligands, by electrokinetic chromatography using highly sulfated
cyclodextrins
E. LIPKA, C. DANEL, H. ORHAN, J.P. BONTE, C. VACCHER
Electrophoresis - (2007) 28(21), 3915-3921
-Analytical and semipreparative enantioresolution of 9-hydroxyrisperidone, main metabolite of risperidone
using high performance liquid chromatography and capillary zone electrophoresis. Validation and
determination of enantiomeric purity
C. DANEL, P. ODOU, C. BARTHELEMY, D. AZARZAR, H. ROBERT, J.P. BONTE, C. VACCHER
Journal of Chromatography A - (2007) 1163(1-2), 226-236
-Chiral resolution of the enantiomers of new selective CB2 receptor agonists by liquid chromatography on
amylose stationary phases
E. STERN, L. GOOSSENS, C. VACCHER, J-P. BONTE, P. DEPREUX, J-P. HENICHART, J-F. GOOSSENS
Journal of Pharmaceutical and Biomedical Analysis - (2008) 46(5), 848-853
-Preparative Enantiomeric Separation of Potent AMP-Activated Protein Kinase Activator by HPLC on
Amylose-Based Chiral Stationary Phase. Determination of Enantiomeric Purity and Assignment of Absolute
Configuration
M.P. VACCHER, J. CHARTON, A. GUELZIM, D.H. CAIGNARD, J.P. BONTE, C. VACCHER
Journal of Pharmaceutical and Biomedical Analysis - (2008) 46(5), 920-928
-Chiral separation of nucleoside phosphoramidates diastereoisomers by high performance liquid
chromatography and capillary electrophoresis.
JF. GOOSSENS, VILLARD AL., PERIGAUD C., BONTE JP., VACCHER C., FOULON C.
Journal of Chromatography B – (2008) 875, 288-295
-LC using two different cellulose polysaccharide chiral stationary phases for direct enantioseparation of
benzoxazolinone aminoalcohols and aminoketones.
E. LIPKA, C. VACCHER, J.P. BONTE
Chromatographia - (2008) 68, 1053-1057
-Risperidone and 9-hydroxyrisperidone : study of the complexation with cyclodextrin-hosts using affinity
capillary electrophoresis and 1H NMR.
C. DANEL, N. AZAROUAL, A. BRUNEL, D. LANNOY, P. ODOU, G. VERMEERSCH, C. VACCHER
Journal of Chromatography A - (2008) 1205 (1), 185-193
-Enantiomeric resolution of benzoxazolinone amino alcohols, potential adrenergic ligands, by LC and CE.
E. LIPKA, C. VACCHER, J.P. BONTE
Chromatographia - (2009) 69, 465-472
-Semipreparative enantioseparation of benzoxazolinone aminoalcohols and their aminoketon precursors,
potential adrenergic ligands, by liquid chromatography on amylose chiral stationary phases. Caracterisation
of the enantiomers.
E. LIPKA, C. VACCHER, J.P. BONTE
Chirality - (2009) 21, 769-776
-Capillary Electrophoresis and High Performance Liquid Chromatography for Chiral Separation of Four
Piperidinic Benzoxazolinone Compounds.
E. LIPKA, C. VACCHER, J.P. BONTE, C. FOULON
Chromatographia - (2009) 69, 903-909
-Tic-hydantoine 1 agonist:, pharmacological characterization on cocaine induced stimulant and appetitive
effects.
TOUSSAINT M., DELAIR B., FOULON C., LEMPEREUR N., VACCHER C., MAURICE C., MELNYK P.
European Neuropsychopharmacology (2009) 19, 504-515
-Enantioseparation of chiral benzimidazole derivatives by electrokinetic chromatography using sulfated
cyclodextrins.
E. LIPKA, J. CHARTON, M.P. VACCHER, M. FOLLY-KLAN, J.P. BONTE, C. VACCHER
Journal of Separation Science - (2009), 32(11), 1907-1915
-Chiral stability of the 9-hydroxyrisperidone. Kinetics and mechanism of racemization
C. DANEL, N. AZAROUAL, D. LANNOY, A. BRUNEL, P. ODOU, B. DECAUDIN, G. VERMEERSCH, J-P.
BONTE, C. VACCHER
Tetrahedron Asymmetry - (2009)
20(10), 1125-1131
-Separation of diastereoisomers of Ara-C phosphotriesters using solid phase extractionand HPLC for the
study of their decomposition kinetic in cell extracts.
C. FOULON, J. TEDOU, S. PEYROTTES, PERIGAUD C., BONTE J-P., C. VACCHER, J.F. GOOSSENS
Journal of Chromatography B – (2009) 877, 3475-3481
-Assessment of the complexation degree of camptothecin derivatives and cyclodextrins using spectroscopic
and separatives methodologies
C. FOULON, J. TEDOU, T. QUERUAU LAMERIE, C. VACCHER, BONTE J-P., J.F. GOOSSENS
Tetrahedron Asymmetry - (2009), 20, 2482-2489
-Chiral capillary electrophoresis with highly sulfated cyclodextrins. Resolution of benzoxazolinone
aminoalcohols and aminoketon precursors, potential adrenergic ligands.
E. LIPKA, M.P. VACCHER, J-P. BONTE, C. VACCHER
Analytical Letters - (2010), 43(15), 2356-2371
-Sigma-1 ligands : Tic-Hydantoin as a key pharmacophore
TOUSSAINT M., MOUSSET M., FOULON C., JACQUEMARD U., VACCHER C., MELNYK P.
European Journal of Medicinal Chemistry - (2010), 45(1), 256-263
-Unambiguous structure elucidation of the reaction products of aryl β-diketoesters with hydroxylamine
V. ANDRZEJAK, J.EL BAKALI, A. GUELZIM, J.P. BONTE, S. GLUSZOK, P. CHAVATTE, R. MILLET, C.
VACCHER
, E. LIPKA
Letters in Organic Chemistry- (2010), 7(1), 32-38
-Dual cyclodextrin system in capillary electrophoresis for direct separation of the four stereoisomers of
agonist and antagonist melatoninergic ligands. »
E. LIPKA, C. DANEL, S. YOUS, J.P BONTE, C. VACCHER
Electrophoresis - (2010) 31(9), 1529-1532
-Separation of Tic-hydantoin enantiomers, potent sigma-1 agonist, by high
performance liquid chromatography and capillary electrophoresis.
AC. CARBODERY, M; TOUSSAINT, JP; BONTE, P. MELNYK, C. VACCHER, C. FOULON
Journal of Chromatography A - (2010) 1217(24), 3871-3875
-Determination of pKa values of benzimidazole derivatives, potent AMPK activators, by capillary
electrophoresis
E. LIPKA, M. FOLLY-KLAN, M.P VACCHER, J. CHARTON, J.P BONTE, C. VACCHER
Journal of Pharmaceutical and Biomedical Analysis - (2010) 53, 1267-1271
-Kinetics and mechanism of racemization of Tic-hydantoins, potent sigma-1 agonists A.C. CABORDERY, M. TOUSSAINT, N. AZAROUAL, J.P. BONTE, P. MELNYK, C. VACCHER, C. FOULON Tetrahedron Asymmetry - (2011)
ACCEPTEE

3) Points forts des activités autres que la recherche :

- ENCADREMENT
-stagiaires du Diplôme Universitaire d’Etudes Pratiques et Théoriques en Sciences du Médicament et Sciences Biologiques de L’Université de Lille 2, de stagiaires BTS, DUT de Chimie, de Master 1 et 2 et de Mastere Encadrement de -Thèses au sein de l’EA 4034 avec publications - ADMINISTRATION
-Membre suppléant élu de la Commission de Spécialistes de 39ème section de l’Université de Lille2 -Membre suppléant nommé de la Commission de Spécialistes des 39, 40 et 41 èmes sections de l’Université d’Amiens -Membre élu du Conseil d’Administration de la Faculté de Pharmacie -Responsable de l’EA 4034 : Groupe de Recherche Analyse du Médicament - COOPÉRATIONS INDUSTRIELLES ET VALORISATION
-Contrat Ligue Contre le Cancer, comité Nord 2004-2006
Intervenant du projet intitulé : « anticancéreux à activité énantiosélective »
-Contrat Industriel
Société DORAN International (Lyon)(Promoteur)
ESSAI CLINIQUE ONCOPERF01
Titre du Projet : « Evaluation de l’impact du dispositif médical d’administration parentérale d’une chimiothérapie anticancéreuse sur les paramètres pharmacocinétiques » -Contrat ANR (collaboration) NEUROSCIENCES (Alzheimer)
Contrat de RECHERCHE
ANR -07-EMPB-034-03 TherAlz
- INFORMATION SCIENTIFIQUE & TECHNIQUE ET VULGARISATION :
-Rapporteur dans les périodiques : Journal of Chromatography A, Journal of Chromatography B, Electrophoresis, Analytica Chimica Acta, Talanta, Journal of Pharmaceutical and Biomedical Analysis, Journal of Separation Science, Chirality. - ENSEIGNEMENTS
Enseignements de chimie analytique en 1er, 2ème et 3ème cycles des études pharmaceutiques Encadrement de :stagiaires du Diplôme Universitaire d’Etudes Pratiques et Théoriques en Sciences du Médicament et Sciences Biologiques de L’Université de Lille 2, de stagiaires BTS, DUT de Chimie, de Master 1 et 2 et de Mastere

Source: http://ea4481.univ-lille2.fr/fileadmin/C.V/FICHE_WEB_CV.pdf

Overview of the updated antiemetic guidelines for chemotherapy-induced nausea and vomiting

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