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Newsletter 200303_final pdf convert.doc

Palliative Medicine Doctors Meeting

Chemical Pleurodesis in Palliative Care patients

- Our experience

Dr BF Chow, Dr PC Li, Dr KS Lau
Ruttonjee Hospital

Malignant pleural effusion (MPE) is a common cause of morbidity in cancer patients in
advanced disease. Carcinoma of lung and breast accounts for the majority (75%) of MPE.
The median survival following diagnosis was 3 to 12 months, largely dependent upon the
underlying malignancy. Patients may present with dyspnoea, cough or chest pain which
compromised their quality of life. Chemotherapy and radiotherapy may be effective means
of palliation in patients with lymphoma, small cell lung carcinoma and breast carcinoma.
Majority of patients with MPE need local intervention for symptomatic control; either in
terms of repeated thoracocentesis, tube thoracostomy alone or tube thoracostomy with
sclerosing agents. Pleuroperitoneal shunt or pleural abrasion and pleurectomy are rarely
performed in our locality. Success rates varied with different modalities employed. The
indications of tube thoracostomy and pleurodesis would take into consideration patients’
expected life expectancy, co-morbidity and general health status. Successful sclerotherapy
probably depends on the choice of sclerosing agents, tube size, amount of pleural fluid
and tumour burden. At present, there is still no universal consensus as to the best and
most effective treatment procotol.
To review our experience with tube thoracostomy with and without chemical
pleurodesis in the management of symptomatic MPE with regards to efficacy, side effects
and recurrence rates.
Retrospective case note review of 53 cancer patients who were managed with tube thoracostomy for symptomatic malignant pleural effusions. The study interval spanned a period of 4 years since January 1997. Thirty three (62%) male patients and twenty (38%) female patients were studied. Their mean age was 70.8 years. Majority (92%) was ambulatory. 4 patients (8%) was moribund in terms of assistance needed in activities of daily living, they had chest drain inserted upon referral to our palliative care unit. The pleural fluid was straw coloured in 56%, blood stained in 40% and pus like in 4%. The mean drainage volume was 2581ml (range: 50-9930ml) and the mean duration of drainage was 7.81 days (range: 1-29 days). Overall symptomatic improvement was shown in 86% of patients [either in terms of less shortness of breath (82%), improved sleep quality (6%) or improved general condition(6%)]. 6% of patients reported feeling the same and 8% got worse after drainage. Forty four patients (44/53; 83%) had chemical pleurodesis done, while nine (9/53; 17%) without after tube thoracostomy either because of trapped lung or tube blockage. Tetracycline was used in 65 % and minocycline in 35% of patients. Only one patient
developed fever after pleurodesis and subsided spontaneously after one day. Five patients
(11.4%) had relapse of pleural effusions . All relapses occurred more than one month after
pleurodesis and two (4.5%) necessitated repeated pleurodesis. Twenty nine (29/44 66%)
patients survived 4 weeks to 9 months after pleurodesis.
Literature Review

The high rate of re-accumulation of pleural fluid after simple aspiration for MPE had
provided the rationale for chemical pleurodesis. Martinez et al1 in a study of 120 cases had
identified several poor response indicators to chemical pleurodesis (pleural fluid glucose <
3.3, pH < 7.20, LDH > 600iu/L; low KPS score < 70, massive pleural effusions and non-
chemosensitive tumours). In another study, Burrows et al2 showed that only the KPS score
at the time of thoracoscopy was predictive of survival. For patients with a KPS score = 70,
it may be very reasonable to proceed with thoracoscopic talc pleurodesis. Parulekar et al3
had found that use of small bore catheters (12F) had similar rate of recurrence of pleural
effusions as large bore chest tubes. In striking the balance between symptomatic
improvement and providing the best quality of life to patient with MPE, Saffron et al4 had
postulated out patient pleurodesis using small-bore (14F) pigtail catheter and Pien et al5
use implantable catheter for trapped lung syndrome.

In our experience, tube thoracostomy and chemical pleurodesis resulted in symptomatic relief in majority of patients. Significant numbers enjoyed symptom reduction for weeks/months before death. The performance status and the survival expectancy would affect the choice of treatment modality. Our study has limitation as it is retrospective, service-based rather than research- based with limited pleural investigation results. Concerning the future direction, small catheter drainage and out-patient pleurodesis

1. Martinez E, Aparico J, Sanchis J et al. Malignant pleural effusion: prognostic factors for
survival and response to chemical pleurodesis in a series of 120 cases. Respiration 1998; 65(2):108-13. 2. Burrows CM, Mathews CW,Colt HG et al. Predicting survival in patients with recurrent symptomatic malignant pleural effusions.Chest 2000; 117:73-78. 3. Parulekar W, Primio GD, Matzinger F et al. Use of small-bore vs large-bore chest tubes for treatment of malignant pleural effusions. Chest 2001;120:19-25. 4. Saffran L, Ost DE, Fein AM et al.Outpatient pleurodesis of malignant pleural effusions using small-bore pigtail catheter. Chest 2000; 118:417-421. 5. Pien GW, Gant MJ, Washam CL et al. Use of an implantable pleural cathe ter for trapped lung syndrome in patients with malignant pleural effusion. Chest 2001;119:1641-1646.

Source: http://www.hkspm.com.hk/newsletter/2003i1_05.pdf


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