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HORIZANT® (ho-ri' zant)
Read this Medication Guide before you start taking HORIZANT and each time you
get a refill. There may be new information. This information does not take the place
of talking to your healthcare provider about your medical condition or treatment. What is the most important information I should know about HORIZANT?
HORIZANT can cause serious side effects:
1. Do not drive after taking your dose of HORIZANT until you know how
HORIZANT affects you, including the morning after you take your dose.
operate heavy machinery or do other dangerous activities until you
know how HORIZANT affects you. HORIZANT can cause sleepiness, dizziness,
slow thinking, and can affect your coordination. Ask your healthcare provider
when it would be okay to do these activities.
2. HORIZANT may cause suicidal thoughts or actions in a very small
number of people, about 1 in 500.
Call a healthcare provider right away if you have any of these
symptoms, especially if they are new, worse, or worry you:
thoughts about suicide or dying
attempt to commit suicide
new or worse depression
new or worse anxiety
new or worse restlessness
new or worse trouble sleeping (insomnia)
new or worse irritability
acting aggressive, being angry, or violent
acting on dangerous impulses
an extreme increase in activity and talking (mania)
other unusual changes in behavior or mood
How can I watch for early symptoms of suicidal thoughts and actions?
Pay attention to any changes, especially sudden changes, in mood,
Keep all follow-up visits with your healthcare provider as scheduled. Call your healthcare provider between visits as needed, especially if you are
Do not stop HORIZANT without first talking to a healthcare provider.
Suicidal thoughts or actions can be caused by things other than medicines. If
you have suicidal thoughts or actions, your healthcare provider may check for
3. HORIZANT may cause a serious or life-threatening allergic reaction
may affect your skin or other parts of your body such as your liver or blood
cells. You may or may not have rash with these types of reactions. Call a
healthcare provider right away if you have any of the following symptoms:
swollen glands that do not go away
swelling of your lips or tongue
yellowing of your skin or eyes
unusual bruising or bleeding
severe fatigue or weakness
unexpected, severe muscle pain
These symptoms may be the first signs of a serious reaction. A healthcare provider should examine you to decide if you should continue taking HORIZANT.
What is HORIZANT?
HORIZANT is a prescription medicine used to treat adults with: moderate-to-severe primary Restless Legs Syndrome (RLS). pain from damaged nerves (postherpetic pain) that follows healing of shingles (a
painful rash that comes after a herpes zoster infection).
HORIZANT is not for people with RLS who need to sleep during the daytime and need to stay awake at night.
HORIZANT is not the same medicine as gabapentin (for example, NEURONTIN® or GRALISE®) and should not be used in its place.
It is not known if HORIZANT is safe and effective in children.
What should I tell my healthcare provider before taking HORIZANT?
Before taking HORIZANT, tell your healthcare provider if you: have or have had kidney problems or are on hemodialysis. have or have had depression, mood problems, or suicidal thoughts or behavior. have or have had seizures. have a history of drug abuse. have any other medical conditions. are pregnant or plan to become pregnant. It is not known if HORIZANT will harm your unborn baby. Talk to your
healthcare provider if you are pregnant or plan to become pregnant while taking HORIZANT. You and your healthcare provider will decide if you should take HORIZANT while you are pregnant.
are breastfeeding or plan to breastfeed. Your body turns HORIZANT into another
drug (gabapentin) that passes into your milk. It is not known if this can harm your baby. You and your healthcare provider should decide if you will take HORIZANT or breastfeed.
Tell your healthcare provider about all the medicines you take
prescription and non-prescription medicines, vitamins, and herbal supplements.
Know the medicines you take. Keep a list of them and show it to your healthcare
provider and pharmacist when you get a new medicine. How should I take HORIZANT?
Take HORIZANT exactly as your healthcare provider tells you to take it. Your
healthcare provider will tell you how much HORIZANT to take and when to take it.
Take HORIZANT tablets whole. Do not
cut, crush, or chew your tablet.
Take HORIZANT tablets with food.
Do not stop taking HORIZANT without talking to your healthcare
If you stop taking HORIZANT suddenly, you may develop side
If you forget to take your medicine at the time recommended by your healthcare
provider, just skip the missed dose. Take the next dose at your regular time. Do
take 2 doses at one time.
If you take too much HORIZANT, call your healthcare provider or go to the
nearest hospital emergency room right away.
What should I avoid while taking HORIZANT?
Do not take other medicines that make you sleepy or dizzy while taking
HORIZANT without first talking with your healthcare provider. Taking HORIZANT with medicines that cause sleepiness or dizziness may make your sleepiness or dizziness worse.
Do not take other gabapentin drugs (for example, NEURONTIN or GRALISE)
Do not consume alcohol when taking HORIZANT. What are the possible side effects of HORIZANT?
See “What is the most important information I should know about
The most common side effects of HORIZANT include: sleepiness dizziness headache
Tell your healthcare provider if you have any side effect that bothers you or that does not go away.
These are not all the possible side effects of HORIZANT. For more information, ask your healthcare provider or pharmacist.
Call your doctor for medical advice about side effects. You may report side
effects to FDA at 1-800-FDA-1088.
How should I store HORIZANT?
Store HORIZANT between 59° and 86°F (15° and 30°C).
Keep HORIZANT dry and away from moisture.
Keep HORIZANT tightly closed in the bottle provided to you. Do not remove any
moisture control packs that may come in the bottle.
Keep HORIZANT and all medicines out of the reach of children.
General Information about the safe and effective use of HORIZANT
Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do not use HORIZANT for a condition for which it was not prescribed. Do not give HORIZANT to other people, even if they have the same symptoms that you have. It may harm them.
This Medication Guide summarizes the most important information about HORIZANT. If you would like more information, talk with your healthcare provider.
You can ask your healthcare provider or pharmacist for information about HORIZANT that was written for healthcare professionals.
For more information about HORIZANT, go to www.HORIZANT.com or call 1-877-
XENOPRT (1-877-936-6778). What are the ingredients in HORIZANT?
gabapentin enacarbil Inactive ingredients:
Both the 300 mg and 600 mg tablets contain colloidal
silicon dioxide, dibasic calcium phosphate dihydrate, glyceryl behenate, magnesium
stearate, sodium lauryl sulfate, and talc. This Medication Guide has been approved by the U.S. Food and Drug
XenoPort, Inc. Santa Clara, CA 95051 Revised: July 2013 HORIZANT is a registered trademark of XenoPort. The other brands listed are trademarks of their respective owners and are not trademarks of XenoPort. The makers of these brands are not affiliated with and do not endorse XenoPort or its products.
2013, XenoPort. All rights reserved. HZT:9MG
Nazarenes and Ebionites - An Introduction © 1998, all rights reserved. Josephus reports four main sects or schools of Judaism: Pharisees, Sadducees, Essenes, and Zealots. The earliest followers of Jesus were known as Nazarenes, and perhaps later, Ebionites, and form an important part of the picture of Palestinian Jewish groups in late 2nd Temple times. The Ebionite/Nazarene movement was mad
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