Drug Name -- Buspar
Alternate Names – Buspirone
Manufacturer – Bristol-Myers Squibb
Type – Prescription (not controlled).
Pregnancy Issues – FDA Pregnancy Class B. Buspar is not expected to cause harm to a fetus or to cause
birth defects. This, however, has not been proven over time. It is not known whether or not Buspar is
transplacental. It is not known whether or not Buspar transfers into breast milk. [Both the transplacental
issue and the breast milk transfer issue should be very easy for the medical community/manufacturer to
determine. Official studies and/or statements have not been made by Bristol-Myers Squibb. This is an
irresponsible action.]
Addiction Potential – According to BMS, Buspar shows no tolerance issues, and no physical or
psychological dependence issues. Buspar is not a drug of abuse. Buspar is only to be used for short-term
relief. This drug should not be administered long-term except in extreme cases and under the direct care
of a psychiatrist (and not from a Primary Care Physician). Buspar does not affix to the GABAa receptor
complex, as does the benzodiazepine class; the manufacturer admits that they do not understand the
mechanism that causes Buspar to work (and associated dangers of that mechanism); while officially BMS
states that Buspar is not addicting, there appear to be consequences (withdrawals) when stopping the
drug. This would indicate physical (but not psychological) dependence issues. Dr. Peter Breggin has
listed the withdrawals and has classified Buspar as an addictive psychoactive drug substance by empirical
studies with patients. [See withdrawals below.]
Maximum Prescription Duration – According to the manufacturer, this drug should not be taken for
more than four weeks. The manufacturer has determined that there is no demonstrated effectiveness of the
drug beyond four weeks of administration. It is also not advisable to prescribe Buspar to patients who
have previously been given any form of benzodiazepines (including Xanax and Valium). Since it is a
bromide-based drug, the effects will become toxic if administered for a sustained period of time.
Cautions – Eating grapefruit, drinking grapefruit juice or consuming grapefruit by-products may cause
sudden death. Buspar should not be administered to people with kidney or liver problems, or heart
problems (including medicated hypertension). In long-term cases of administration blood tests must be
administered for kidney and liver functionality since Buspar diminishes kidney and liver functions;
Buspar should not be taken by individuals with seizure disorders; some people report feeling “mixed up”
or “messed up” in their ability to make decisions and thus they become frozen in their ability to make
decisions; alcohol should not be used in conjunction with Buspar; all sleeping drugs including hypnotics
should be avoided (including over-the-counter sleep medications and Ambien).
Drug Interactions/Adverse affects – MAOI drugs may cause serious or fatal reactions with Buspar.
These reactions including Marplan, Nardil, Azilect, Eldepryl, Emsam, or Parnate; Cold and allergy
medicines; narcotics of all types; sleeping medication (prescription and non-prescription); muscle
relaxers; seizure medication; Thorazine, Haldol, Serentil, Orap, or Mellaril; Decadron or Hexadrol;
erythromycin (and its derivatives); Sporanox or Nizoral; Norvir; Rifadin, Rimactane, or Rifater; Capastat,
Rifadin, Rimactane, Rifater, Vancocin, or Vanocin; calcium blockers such as Tiazac, Cartia, Cardizen,
Calan,Covera, Isoptin, or Verelan; seizure medications such as Carbatrol, Tegretol, Dilantin, Luminal, or
Solfoton; the concomitant use of Buspar with other CNS-active drugs has not been studied and extreme
caution should be used. [This list is not complete.]
Class – Azaspirodecanedione (not a benzodiazepine and not affixed to the GABAa receptor complex; this
is a bromide-based drug substance that will be toxic over time. All bromides are dangerous to human
Purpose – Reduction of anxiety symptoms, reduction of panic attacks, treatment of Generalized Anxiety
Disorder (not deemed as effective for other Axis I Anxiety Disorders).
Side Effects – Buspar may cause illogical thinking, confusion, and illogical decision-making capabilities
that may seriously effect life decisions; extreme emotional instability has been indicated in some cases
(including despair that leads to suicidal ideation or suicide attempts), feelings of catastrophe and utter
despair without the ability to act or react accordingly and logically; Buspar is only minimally reactive to
alcohol and in its responsible use should not result in overdose symptoms; other side effects include lack
of coordination; drowsiness, dizziness, blurred vision; restlessness; nausea, upset stomach, diarrhea;
insomnia; since Buspar binds to dopamine receptors, it may cause dystonia, pseudo-parkinsonism,
akathisia, and tardive dyskinesia; cardiovascular side effects include chest pain, hypotension,
hypertension, congestive heart failure, heart attack, and bradycardia; central nervous system effects
include dream disturbances, depersonalization, dysphoria, noise intolerance, euphoria, akathisia,
fearfulness, loss of interest in life, dissociative reaction, hallucinations, suicidal ideation, seizures, slurred
speech and psychosis; gastrointestinal effects include stomach problems including diarrhea, nausea, and
vomiting, extreme flatulence, rectal bleeding, increased appetite and weight gain; muscular effects
include muscle cramps, muscle spasms and arthralgias; sexual/genital side effects include leaking breasts,
urinary hesitancy, menstrual irregularity, enuresis, nocturia, libido dysfunctions, and impotence.
Withdrawals – Some people report that initial cessation of Buspar results in extreme confusion and
complete inability to act or react to life situations; illogical and damaging decisions can be made; vacating
of all emotional response to life; extreme headaches similar to migraines; nausea; life-threatening
neurological reactions; extreme anxiety; extreme and pathological depression; abdominal pains; aching;
agoraphobia; blurred vision; altered and bizarre perceptions; diarrhea; distended abdomen; feeling of
unreality; flatulence; food cravings and extreme weight gain; hair loss; heart palpitations; insomnia;
lethargy; loss of balance; metallic taste; muscle spasms; nightmares; panic attacks; paranoia and
unrealistic fears; persistent and unpleasant memories; hippocampus disruption resulting in short-term
memory issues (unclear if these issues are permanent); speech difficulties; sweating; and sudden suicidal
ideations/suicide attempts. [See Dr. Peter Breggin’s work regarding Buspar addiction and withdrawal at]
Sources –,,
[Editorial Note: In my research of psychoactive drug substances I only include indications that come from the manufacturer or reputable drug-related focus groups. I do not include personal opinion or enhancements of facts from sources. With this drug, however, I must issue a caution due to information that I discovered on personal forums dedicated to this drug and its effects on people. Individuals who had taken or were currently taking Buspar consistently complained of severe alteration of decision-making abilities to the point where the diminution of those abilities severely altered life. Individuals consistently complained, also, of even more severe cognitive and emotional disturbances when attempting to discontinue use of the drug. One individual classified this drug as a “demon in pill form” and complained that it was destroying his life. Although this information is not scientific or tempered through official sources, users should beware of these potential effects from actual users.]


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