Niperahm.edu.in

Dr. MANISH NIVSARKAR
B.V. Patel Pharmaceutical Education and Research Development (PERD) Centre, Sarkhej- Gandhinagar Highway, Thaltej, Ahmedabad-380054 Telephone: 91 79 27439375, Fax: 91 79 27450449 Current Position: Director
……………………………………………………………………………………………………………  Joint Director, Head Department of Pharmacology and Toxicology: B. V. Patel PERD
 Assistant Director, Head Department of Pharmacology and Toxicology: B. V. Patel
 Scientist-C, Head Department of Pharmacology and Toxicology: B. V. Patel PERD
 Scientist-B, Head Department of Pharmacology and Toxicology: B. V. Patel PERD
 Scientist A: Department of Pharmacology and Toxicology: B. V. Patel PERD Centre,
 Research Scientist: M.R.S. Hurkisondas Narrotamdas Hospital Mumbai, 1993-96
 Research Associate (CSIR): School of Life Sciences, Devi Ahilya University, Indore,
……………………………………………………………………………………………………………  Ph.D. (Life Sciences), Thesis title: “Biochemical mechanism behind the phototoxicity
of α-terthienyl: Its use as a mosquito control agent” - Devi Ahilya University Indore, 1988-  M. Sc. (Animal Sciences) - Rohilkhand University Bareilly, 1985-1987.
……………………………………………………………………………………………………………  Toxicology, Molecular Pharmacology, Drug Delivery, Biomarkers, Reproductive Physiology, Diabetes and its complications and Inflammatory disorders. ……………………………………………………………………………………………………………  “New topical formulation of Berberine & its derivative tetrahydroberberine for post kala- azar Leishmaniasis” Hemangi Bagadiya, Hitesh B. Jalani, Kamala K. Vasu, Manish
Nivsarkar. Presented in 3rd CDRI-NIPER (RBL) Symposium on Medicinal Chemistry
and Pharmaceutical Sciences CDRI, Luknow, 3-5 March, 2011, (This poster won the
1st prize).
 Ranjeet Prasad Dash, Bhupendrasinh F. Chauhan, Sheetal Anandjiwala, Manish
Nivsarkar. Certificate of Merit - “Dr. P.D. Sethi Annual Award for Best Paper in
Pharmaceutical Analysis” 2010.
 Pradeep Dabhi, Sheetal Anandjiwala, Manish Nivsarkar. 1st Prize in 14th National
Convention of Society of Pharmacognosy, Hindu College of Pharmacy, Sonipat,
 Nimesh Modi, Sheetal Anandjiwala, Manish Nivsarkar. 3rd Prize in 14th National
Convention of Society of Pharmacognosy, Hindu College of Pharmacy, Sonipat,
 Baljinder Singh, Pankaj Mungara, Manish Nivsarkar, Sheetal Anandjiwala. Certificate
of Appreciation - “Dr. P.D. Sethi Research Paper Annual Award on Application of
LC/HPTLC in Pharma, Herbal and Miscel aneous Analysis” 2009.
 Baljinder Singh, Pankaj Mungara, Sheetal Anandjiwala, Manish Nivsarkar. 2nd Prize in
Gujarat State Pharmacy Paper Presentation-conducted by GUJCOST, Shri
Sarvajanik Pharmacy College Mehsana, Gandhinagar, January 2009.  Swati Pund, Amita K Joshi, Kamala K Vasu, Manish Nivsarkar. 2nd Prize in Gujarat
State Pharmacy Paper Presentation-conducted by GUJCOST, Shri Sarvajanik
Pharmacy College Mehsana, Gandhinagar, January 2009.  Aryamitra Banerjee and Manish Nivsarkar. Govind Achari Prize. 40th Annual
Conference of Indian Pharmacological Society, NIPER-SAS Nagar, November 2007.
 Aryamitra Banerjee and Manish Nivsarkar. 1st Prize in UGC-DSA Symposium on
“Recent Advances in Reproduction, Endocrinology & Development and
Associated Disorders”, The M. S. University of Baroda, Vadodara, January 2006.
 Bhupendrasinh Chauhan and Manish Nivsarkar. 3rd Prize in National Symposium on
Contemporary Developments in Life Sciences, Hemchandracharya North Gujarat
……………………………………………………………………………………………………………  Singh B., Nadkarni J.R., Vishwakarma R.A., Bharate S.B., Anandjiwala, S. and Nivsarkar, M. (2012) The hydroalcoholic extract of Cassia alata (Linn.) leaves and its
major compound rhein exhibits antiallergic activity via mast cell stabilization and lipoxygenase inhibition (Available Online)  Patil, S., Dash, R. P., Anandjiwala, S. and Nivsarkar, M. (2012) Pharmacokinetic
study of berberine from Rasont and implication of lysergol for its bioavailability enhancement. Journal of Liquid Chromatography and Related Technologies
 Patil, S., Dash, R.P., Anandjiwala, S. and Nivsarkar, M. (2011) Simultaneous
quantification of berberine and lysergol by HPLC-UV: Evidence that lysergol enhances the oral bioavailability of berberine in rats. Biomedical Chromatography
(Accepted). Impact Factor: 1.545
 Yadav, H., Mungara, P., Jivrajani, M., Nivsarkar, M and Anandjiwala S. (2011) TLC-
Densitometric Quantification of Negundoside, Ursolic Acid, Eugenol, Lupeol and β- sitosterol using HPTLC from Vitex negundo Leaves. Journal of Liquid
Chromatography and Related Technologies (Accepted). Impact Factor: 0.953
 Pund S., Joshi, A., Vasu, K., Nivsarkar, M. and Shishoo, CJ (2011) Gastroretentive
delivery of refampicin: in vitro mucoadhesion and in vivo gamma scintigraphy. International Journal of Pharmaceutics 411(1-2), 106-112. Impact Factor: 3.607
 Patel, V., Chudasama, A., Nivsarkar, M., Vasu, K and Shishoo, CJS (2011) Push-
Pull osmotic pump for zero order delivery of lithium carbonate: development and in vitro characterization. Pharmaceutical Development and Technology (in press,
available online). Impact Factor: 1.107
 Banerjee, A., Vasu, K., Pancholi, H., Rajani, M. and Nivsarkar, M (2011)
Detoxification of Nerium indicum roots based on Indian System of Medicine: Phytochemical and Toxicological Evaluation. Acta Poloniae-Drug Research 68(6),
 Banerjee, A., Padh, H and Nivsarkar, M. (2011) Hormonal Crosstalk with calcium
channel blocker during implantation Systems Biology in Reproductive Medicine
Vol. 57(4), 186-189. Impact Factor: 0.800
 Shep, D., Ojha, A., Patel, S., Nivsarkar, M, Jaiswal, V and Padh, H (2011)
Bioequivalence and pharmacokinetic evaluation of two formulations of fenofibrate 145 mg in healthy Indian subjects. Journal of Pharmaceutical and Biomedical
Research 7(7) 1-5.
 Joshi, A., Pund SV., Nivsarkar, MA., Vasu KK and Shishoo, CJ (2011) Exploring the
potential of polacrilin potassium as a novel superdistintegrant in microcrystalline cellulose based pellets prepared by extrusion-spheronization. Chronicles of Young
Scientists Vol. 2(2), 114-116.
 Chudasama, A., Patel V., Nivsarkar, M., Vasu, K.K. and Shishoo, CJ (2011) A novel
lipid based oral drug delivery system of Nevirapine. International Journal of
Pharmaceutical Technology and Research. Vol. 3(2), 1159-1168.
 Chudasama, A., Patel V., Nivsarkar, M., Vasu, K.K. and Shishoo, CJ (2011)
Investigation of microemulsion system for transdermal delivery of itraconazole. Journal of Advanced Pharmaceutical Technology and Research Vol. 2(1), 30-38.
 Shep, D., Ojha, A., Patel, S., Nivsarkar, M, Jaiswal, V and Padh, H (2011)
Comparative Bioavailability Study of a New Formulation of Injection of 75 Mg Diclofenac Sodium in 1 Ml with the Conventional Injection of 75 Mg Diclofenac Sodium Given in 3 Ml Volume Current Clinical Pharmacology 6(1), 26-29. Impact
Factor: 2.500
 Vyas, T., Dash, R.P., Anandjiwala, S., Nivsarkar, M. (2011) Formulation and
pharmacokinetic evaluation of hard gelatin capsule encapsulating lyophilized Vasa Swaras for improved stability and oral bioavailability of vasicine. Fitoterapia. 82(3),
446-453. Impact Factor: 1.899
 Shep, D., Ojha, A., Patel, S., Nivsarkar, M, Jaiswal, V and Padh, H. (2010)
Pharmacokinetic profile of a new formulation of injection diclofenac in Indian volunteers with BMI > 25. Journal of Pain Research, 3, 235-240.
 Shep, D., Ojha, A., Patel, S., Nivsarkar, M, Jaiswal, V and Padh, H. (2010)
Bioequivalence and pharmackokinetic evaluation of two formulations of paracetamol ER 650 mg: A single dose randomized two period crossover comparison in healthy Indian adult volunteers. International Journal of Current Pharmaceutical
Research Vol. 2(4) 28-31.
 Dash, R.P., Chauhan, B.F., Anandjiwala, S., Nivsarkar M. (2010) Comparative
pharmacokinetics profile of Vasa Swaras with vasicine and vasicinone. Chromatographia. 71(7), 609-615. Impact Factor: 1.438
 Pund, S., Joshi, A., Vasu, K., Nivsarkar, M., Shishoo, C.J. (2010) Multivariate
optimization of formulation and process variables influencing physico-mechanical characteristics of site-specific release isoniazid pellets. International Journal of
Pharmaceutics. 388, 64-72. Impact Factor: 3.607
 Dash R.P. and Nivsarkar, M (2010) Current Perspectives in Bioavailability
Enhancement. In: Souvenir, 6th International Symposium on Pharmaceutical Innovation in Science and Technology, Nov. 26-28th, 2010, Ahmedabad, India.  Thakur, S. and Nivsarkar, M (2010) Applications of Bioinformatics. In: Souvenir, 6th
International Symposium on Pharmaceutical Innovation in Science and Technology,  Chauhan, B. and Nivsarkar, M (2010) Future Prospects for CRO: Indian Capabilities.
 Mahajan, S., Banerjee, A., Chauhan, B., Padh, H., Nivsarkar, M. and Mehta, A.
(2009) Inhibitory Effect of n-butanol fraction of Moringa oleifera Lam. Seeds on OVA-
Induced Airway Inflammation in murine model of asthma. International Journal of
Toxicology 28(6), 519-527. Impact Factor: 1.243
 Singh, B, Mungra, P., Nivsarkar, M and Anandjiwala, S (2009) HPTLC densitometric
quantification of Glycyrrhizin, Glycyrrhetinic Acid, Apigenin, Kaempferol and quercetin from Glycyrrhiza glabra. Chromatographia 70, 1665-1672. Impact Factor:
 Nivsarkar, M and Banerjee, A (2009) Establishing the probable mechanism of L-
DOPA in Alzheimer’s disease management. Acta Polonica 66(5), 483-486.
 Banerjee, A., Padh, H. and Nivsarkar, M. (2009) Role of calcium channel in
blastocyst implantation: A novel contraceptive target Journal of Basic and Clinical
Physiology and Pharmacology 20 (1) 43-53.
 Ojha, A., Shep, D., Nivsarkar, M., Patel, S., Jaiswal, V and Padh, H (2009)
Pharmacokinetic profile of a new formulation of injection diclofenac designed for intradeltoid use. Expert Opinion on Pharmacotherapy. 10(4) 517-522. Impact
Factor: 2.018
 Nivsarkar, M., Banerjee, A. and Padh, A (2008) Cyclooxygenase inhibitors: A novel
direction for Alzheimer’s management. Pharmacological Reports. 60, 692-698.
 Chauhan, B, Patel, M.M., Padh, H. and Nivsarkar, M. (2008) Combination
Therapeutic Approach for Asthma and Allergic Rhinitis. Current Clinical
Pharmacology. 3(3), 185-197. Impact Factor: 2.500
 Joshi, A., Pund, S., Nivsarkar, M., Vasu, K. and Shishoo, C (2008) Dissolution test
for site-specific release isoniazid pellets in USP Apparatus 3 (reciprocating cylinder): European
Journal
Pharmaceutics and Biopharmaceutics 69(2), 769-775. Impact Factor: 4.304
 Rani, S., Singh, G., Banerjee, A., Nivsarkar, M and Padh, H. (2008) Single and
multiple dose toxicokinetics of rofecoxib in Sprague Dawley rats: Implication of drug accumulation and sex differences. Advances in Pharmacology and Toxicology 9
 Rani, S., Banerjee, A., Nivsarkar, M., Singh, G., Patel, M and Padh, H. (2008) Serial
and Sparse Sampling Approaches in Single and Multiple Dose Toxicokinetic Studies: A comparison. International Journal of Pharmacology and Biological Sciences.
 Franklin, PX. Yerande, S., Sudarsanam, S., Padh, H., Nivsarkar, M. and Vasu, KK
(2008) 2 Amino-5-thazzolyl Motif: A novel scaffold for designing anti-inflammatory
agents of diverse structures. European Journal of Medicinal Chemistry. 43 (1),
129-134. Impact Factor: 3.193
 Banerjee, A., Vaghasiya, R., Shrivastava, N., Padh, H. and Nivsarkar, M. (2007)
Endometrial membrane response in Mus musculus during implantation by Vitex negundo Linn. Animal Reproduction 4, 46-50.
 Banerjee, A., Dholakia, D., Nivsarkar, M (2007) Alterations in uterine Environment
by Adrenal Feedback Mechanism during Estrous Cycle. Journal of Biological
Research. 8, 217-222. Impact Factor: 0.583
 Banerjee, A., Vaghasiya, R. and Nivsarkar, M. (2007) Adrenalectomy potentiates the
anti-inflammatory activity of a calcium channel blocker. Journal of Basic and
Clinical Physiology and Pharmacology. 18(4), 299-306.
 Shrivastava, N., Kothari, A., Patel, T and Nivsarkar, M. (2007) Phytochemical
evaluation and radical scavenging activity of three members from family asteraceae. Indian Drugs 44(10), 751-756.
 Rathod, R., Prasad, L.P., Rani, S., Nivsarkar, M. and Padh, H (2007) Estimation of
carvedilol in human plasma by using HPLC-fluorescence detector and its application to pharmacokinetic study. Journal of Chromatogr B Analytical Technology and
Biomedical Life Sciences. 857(2):219-23. Impact Factor: 2.971
 Vaghasiya, R., Banerjee, A., Shrivastava, N. and Nivsarkar, M. (2007) Analgesic
and anti-inflammatory activity of hydroalcoholic extract of Morus alba Linn. Indian
Drugs 44(5), 364-367.
 Chaula Patel, Patel, M., Rani, S., Nivsarkar, M. and Padh, H. (2007) A new high
performance liquid chromatographic method for determination of atomoxetine in human plasma and its application for pharmacokinetic study. Journal of
Chromatography B. 850, 356-360. Impact Factor: 2.971
 Banerjee, A., Vaghasiya, R., Shrivastava, N., Padh, H. and Nivsarkar, M. (2006)
Anti-hyperlipidemic effect of Carica papaya L in Sprague-Dawley rats. Nigerian
Journal of Natural Products and Medicine. 10, 69-72.
 Chauhan, B., Rani, S., Nivsarkar, M and Padh, H (2006) A New Liquid-Liquid
Extraction Method for Determination of Montelukast in Small Volume Human Plasma Samples Using HPLC with Fluorescence Detector. Indian Journal of
Pharmaceutical Sciences. 68(4) 517-520. Impact Factor: 0.630
 Shrivastava, N., Srivastava, A., Banerjee, A and Nivsarkar, M (2006) Anti-Ulcer
activity of Adhatoda vasica Nees. Journal of Herbal Pharmacotherapy. 6(2) 43-50.
 Nivsarkar, M, Banerjee, A., Shah D., Trivedi, J., Patel, M., Bapu Cherian Padh, H.
(2006) Reduction in aluminum induced oxidative stress by meloxicam in rat brain: an
in vivo and in vitro study. Iranian Biomedical Journal. 10(3) 151-155.
 Nivsarkar, M, Banerjee, A., Shah, D. and Kurani, S.P. (2006), Wound Healing
Activity of Hemolok (Sepgard) Gel in Sprague Dawley Rats. Advances in
Pharmacology and Toxicology. 7(1), 21-23.
 Banerjee, A., Shrivastava, N., Kothari, A., and Nivsarkar, M (2005) Wound Healing
Activity Of Tridax Procumbens. Advances in Pharmacology and Toxicology. 6(1),
 Rani, S., Guttikar, S., Zope, A., Rathod, R. Nivsarkar, M. and Padh, H. (2005)
Zafirlukast pharmacokinetics in healthy Indian male subjects: possibility of interethenic variability. The Indian Journal of Allergy, Asthma and Immunology.
 Banerjee, A., Shrivastava, N., Padh, H and Nivsarkar, M. (2005) Anti Ulcer Activity
of Methanolic Extract of Sapindus Mukorossi. Indian Drugs. 42(6), 380-383.
 Rani, S., Nivsarkar, M, Rathod, R. Padh, H. (2005) Comparative bioavailability of
micronised fenofibrate capsule with the newly developed formulation of fenofibrate (FENO-TG) in healthy human volunteers. Cardiology Update, (1) 29-32.
 Rani, S., Nivsarkar, M, Rathod, R., Guttikar, S and Padh, H. (2005) Bioequivalence
of fenofibrate tablet formulations in healthy Indian male subjects. Indian Journal of
Pharmaceutical Sciences. 67(3), 297-301. Impact Factor: 0.630
 Nivsarkar, M, Patel, M., Padh, H., Cherian B. and Shrivastava, N. (2005), Blastocyst
Implantation failure in mice due to “non receptive endometrium”: endometrial alterations by Hibiscus rosa sinnensis leaf extract. Contraception 71(3), 227-230.
Impact Factor: 2.369
 Banerjee, A., Shrivastava, N., Kothari, A., Padh H. and Nivsarkar, M (2005) Anti
Ulcer Activity of Methanolic Extract of Eclipta Alba. Indian Journal of
Pharmaceutical Sciences. 67(2), 169-172. Impact Factor: 0.630
 Banerjee, A. and Nivsarkar M (2005) Search for new contraceptive targets. In:
Pharmaceutical Research and Technology, Nov. 25-29, 2005, Mumbai, India.  Padh, H., Rani, S. and Nivsarkar, M (2005). Pharma Industry – Opportunities Post
2005. Proceedings of Seminar on Chemicals & Pharmaceuticals., Global Investors’  Shubha Rani, Guttikar, S., Rathod, R., Cherian, B., Nivsarkar, M and Padh, H.
(2004) Determination of oral meloxicam pharmacokinetic parameters in Asian
Indians: comparison with German population. Saudi Arabian Journal of
Pharmaceutical Sciences. 12(4) 144-149.
 Patel, M., Cherian, B., Padh, H and Nivsarkar, M (2004) Olanzepine induced
thrombocythemia in Spargue-Daley rats. Drug Chemical and Toxicology 27(4) 379-
387. Impact Factor: 3.207
 Nivsarkar M, Rathod, P.D., Vasu, K., Zope, A., Sudarsanam, V., Bapu, C. and Padh,
H. (2004) Altered glucose tolerance by guanidinothiourea compound in Sprague-
Daley rats: possible mechanism(s) for hyperglycemia. Indian Drugs 41(5) 294-297.
 Cherian, B., Rathod, R., Guttikar, S., Nivsarkar M., Rani, S. and Padh, H (2004) A
rapid selective and sensitive method for extraction and analysis of celecoxib in Human Plasma. Indian Drugs 41(4) 221-225.
 Nivsarkar, M (2003) Modulation of platelet membrane by free radical induced lipid
peroxidation. Indian Drugs. 40(8), 479-481.
 Pillai, A.D., Rathod, P.R., Franklin, P.X., Patel, M., Nivsarkar, M, Vasu, K.V., Padh,
H. and Sudarsanam, V. (2003) Novel designing approach for dual inhibitors as anti-
inflammatory agents: implication of pyridine template. Biochemical and Biophysical
Research Communications. 301(1), 183-186. Impact Factor: 2.548
 Cherian, B., Sood, P.P. and Nivsarkar, M (2003) Organelle specific enzyme markers
as indicators of methylmercury neurotoxicity and antidotal efficacy in mice. Biometals 16, 279-284. Impact Factor: 3.172
 Nivsarkar, M, Shrivastava, N., Patel, M., Padh, H. and Cherian, B. (2002) Sperm
membrane modulation by Sapindus mukorossi during sperm maturation. Asian
Journal of Andrology. 4(3), 233-235.
 Shubha Rani, Guttikar, S., Zope, A., Cherian, B., Nivsarkar, M and Padh, H. (2002)
Pharmacokinetics of olanzepine in Asian Indians and comparison with other population: possibility of inter ethnic differences. Indian Drugs 39(11) 583-588.
 Nivsarkar, M, Mukherjee, M. Patel, M., Padh, H and Cherian, B (2002) Launaea
nudicaulis leaf juice exhibits anti-inflammatory action in acute and chronic inflammation models in rats. Indian Drugs, 39(5), 290-292.
 Nivsarkar M, Sethi, A., Cherian, B., Patel, M. and Padh, H. (2001) Involvement of
endometrial membrane sulphydryl groups in blastocyst implantation: sulphydryl groups as a potential target for contraceptive research. Contraception 64(4) 255-
259. Impact Factor: 2.369
 Nivsarkar M, De, P., Patel, K.B., Katewa, A, Padh, H. and Bapu, C. (2001) Sub
acute toxicity of meloxicam a selective COX-2 inhibitor in mice. Advances in
Pharmacology and Toxicology. 2(2), 27-31.
 Nivsarkar, M, Cherian, B. and Padh, H. (2001) Alpha-terthienyl: a plant derived new
generation insecticide. Current Science 81(6), 667-672. Impact Factor: 0.567
 Bapu, C., De, P., Patel, K.B., Katewa, A., Nivsarkar, M and Padh, H. (2001) Sub-
acute toxicity study of meloxicam a selective COX-2 inhibitor in rats. Indian Journal
of Toxicology. 8(2), 163-168.
 Nivsarkar, M and Padh, H (2001) Pulse of Indian Pharma Sector: Issues and
opportunities. In: Indian Pharma Industry Issues and Options. PP: 37-54.  Nivsarkar, M, (2000), Improvement in circulating superoxide dismutase levels: role
of nonsteroidal anti-inflammatory drugs is rheumatoid arthritis. Biochemical and
Biophysical Research Communications. 270, 714-716. Impact Factor: 2.548
 Nivsarkar, M, (1999) Identification of alpha-terthienyl radical in vitro: a new aspect in
alpha-terthienyl phototoxicity. Current Science, 76(10), 1391-1393. Impact Factor:
 Nivsarkar, M, Cherian, B. and Patel, S. (1998) A regulatory role of sulphydryl groups
in modulation of sperm membrane conformation by heavy metals: sulphydryl groups as markers for infertility assessment. Biochemical and Biophysical Research
Communications. 247, 716-718. Impact Factor: 2.548
 Nivsarkar, M, Patel, R.Y. and Mokal, R. (1996) Modulation of sperm membrane
confirmation by pentoxifylline in oligopsermia: a biophysical investigation of sperm membrane in vitro. Biochemical and Biophysical Research Communications.
225, 791-795. Impact Factor: 2.548
 Nivsarkar, M, Desai, A. and Mokal, R. (1996) Free radical induced biophysical
modification of membrane lipids: a novel mechanism proposed for the haemorheological alteration by 4,5,8’ trimethyl psoralen. Biochemistry and
Molecular Biology International. 38, 325-333.
 Nivsarkar, M, Kumar, G.P. and Laloraya, M. (1996) Metal binding and resultant loss
of phototoxicity of alfa-terthienyl: metal detoxification versus alpha-terthienyl inactivation. Bulletin of Environmental Contamination and Toxicol. 15, 183-189.
Impact Factor: 0.992
 Nivsarkar, M, Kumar, G.P. and Laloraya, M. (1994) Photophysical alterations of
erythrocyte membrane by 4, 5, 8’ trimethyl psoralen: membrane response towards Biochemical
and
Biophysical
Research
Communications. 199, 1413-1421. Impact Factor: 2.548
 Nivsarkar, M, Kumar, G.P., Laloraya, M. and Laloraya, M.M. (1993) Effect of
ultraviolet light activated alpha-terthienyl upon anal gills of mosquito larvae: a spin label study. Biochemical Systematics and Ecology. 21, 441-447. Impact Factor:
 Nivsarkar, M, Kumar, G.P., Laloraya, M. and Laloraya, M.M. (1992) Generation of
superoxide anion radical by alpha-terthienyl in the anal gills of mosquito larvae of aedes aegypti: a new aspect in alpha-terthienyl phototoxicity. Archives of Insect
Biochemistry and Physiology. 19, 261-270. Impact Factor: 1.381
 Nivsarkar, M, Kumar, G.P., Laloraya, M. and Laloraya, M.M. (1991) Superoxide
dismutase inactivation by alpha-terthienyl: a novel observation in thiophene photochemistry. Pesticide Biochemistry and Physiology. 41, 53-59. Impact
Factor: 1.719
 Nivsarkar, M, Kumar, G.P., Laloraya, M. and Laloraya, M.M. (1991) Superoxide
dismutase in the anal gills of mosquito larvae of Aedes aegypti: its inhibition by alpha-terthienyl. Archives of Insect Biochemistry and Physiology. 16(4), 249-255.
Impact Factor: 1.381
 Kumar, G.P., Sinha, S., Laloraya, M. and Nivsarkar, M (1991) Enhanced axial
symmetry at the Fe (II) heme center of peroxidase by ascorbate: the basis for ascorbate dependent peroxidase action. Biochemical and Biophysical Research
Communications. 180, 597-601. Impact Factor: 2.548
 Singh, A., Kumar, G.P., Laloraya, M., Verma, S. and Nivsarkar, M (1991)
Superoxide dismutase activity regulation by spermine: a new dimension in spermine biochemistry and sperm development. Biochemical and Biophysical Research
Communications. 177, 420-426. Impact Factor: 2.548
 Verma, S., Kumar, G.P., Laloraya, M., Nivsarkar, M and Singh, A. (1991)
Superoxide dismutase activation in thyroid and suppression in adrenal: novel pituitary regulatory routes. FEBS Letters, 282, 310-312. Impact Factor: 3.541
 Kumar, G.P., Seervani, N., Laloraya, M., Nivsarkar, M, Verma, S. and Singh, A.
(1990) Superoxide dismutase as a regulatory switch in mammalian testicular
steroidogenesis. Biochemical and Biophysical Research Communications. 173,
302-308. Impact Factor: 2.548
 Kumar, G.P., Seervani, N., Laloraya, M., Nivsarkar, M, Verma, S. and Singh, A.
(1990) Superoxide anion radical induces lipid phase transitions that mimics
temperature induced phase transition phenomenon of membrane lipids. Biochemical and Biophysical Research Communications. 172, 601-607. Impact
Factor: 2.548
 Verma, S., Kumar, G.P., Laloraya, M., Singh, A., Nivsarkar, M and Bharti, S. (1990)
Discovery of a novel and alternate hydrogen peroxide generation machinery in the mammalian thyroid gland that modulates iodization of tyrosine. Biochemical and
Biophysical Research Communications. 169, 1-7. Impact Factor: 2.548
 Laloraya, M., Kumar, G.P., Nivsarkar, M and Laloraya, M.M. (1990) Localization of
superoxide dismutase in the ovary and uterus of mice during pregnancy with special reference to luteal steroidogenesis and implantation. Acta Histochemica et
Cytochemica. 23, 271-279. Impact Factor: 1.600
……………………………………………………………………………………………………………  Oral gastro retentive fixed dose pharmaceutical compositions for the treatment of tuberculosis and process for preparation thereof’ Indian Patent Application No: 2829/MUM/2009. …………………………………………………………………………………………………………… Government:
 2007-2010, Awarded by the Department of Biotechnology (DBT), India for “Drug Delivery
and Drug Targeting using therapeutic nano particles”.  2006-2008, Awarded by the Indian Council of Medical Research (ICMR) for “Study on
antioxidative property of Kalemgh Andrographis paniculata on experimental cataract”.  2004-2007, Awarded by the Department of Biotechnology (DBT), India for “Clinical trials
of a standardized preparation of Terminalia arjuna in patients with left ventricular  2004-2006, Awarded by the Indian Council of Medical Research (ICMR) for “Chemical
chromatographic evaluation of ayurvedic herbal drugs pre and post shodhana process”.  2004-2005 Awarded by Gujarat Council on Science and Technology (GUJCOST)
Ministry of Science and Technology, Gujarat for “The use of laboratory animals in toxicokinetic studies using sparse sampling approach”.  2002-2003, Awarded by Gujarat Council on Science and Technology (GUJCOST)
Ministry of Science and Technology, Gujarat for “Reducing the use of laboratory animals in toxicokinetic studies using sparse sampling: a model dependent approach”.  2002-2004, Awarded by Gujarat Council on Science and Technology (GUJCOST)
Ministry of Science and Technology, Gujarat for “Evaluation of new herbal anti- inflammatory drugs from family asteraceae”.  2002-2004, Awarded by Gujarat Council on Science and Technology (GUJCOST)
Ministry of Science and Technology, Gujarat for “A new role of anti-inflammatory drugs in the treatment of neuro-inflammatory diseases”.  2011-2013, Awarded by the Gujarat State Biotechnology Mission (GSBTM), Ministry of
Science and Technology , Gujarat for “A non viral vector for inducing pluripotency”  2011-2013, Awarded by the Department of Biotechnology (DBT): Ministry of Science and
Technology, India for “Pharmacokinetics of Picrorhiza kurroa”.  2009-2012, Awarded by the Department of Biotechnology (DBT): Ministry of Science and
Technology, India for “Novel Time modulated release drug delivery system of FDC of Rifampicin and Isoniazid for improved bioavailability and stability” Industries:
 Toxicity studies (> 130) such as Acute, Sub-Acute, Chronic, Sub-Chronic for chemical and herbal compounds, efficacy studies for herbal formulations, Bioequivalence and …………………………………………………………………………………………………………… Invited lectures/conferences/symposia (2010 onwards):  The “6th International Symposium on Innovations in Pharmaceutical Sciences & Technology” held at Cambay Grand, Ahmedabad in November 2010.  Key roles in the organization of workshops and conducting continuing education programs for the benefit of doctoral and post doctoral students and staff from industry  Presently teaching faculty for common courses like basis of drug action, spectral analysis, separation techniques and specialized topics for natural product students and courses in medicinal chemistry for MS (pharmaceutical science) at NIPER Ahmedabad  As Invited speaker delivered lectures on various topics related to Toxicity, Good Laboratory Practices, Pharmacology, Documentation, Data generation and experimental design at various Universities and Organizations. ……………………………………………………………………………………………………………  Member of the editorial board for the International Journal of Pharmacology and  Ethics committee member – Dr. Jivraj Mehta Hospital Ahmedabad.  Visiting faculty at Iladevi Cataract Centre.  Reviewed a number of papers from various national and international journals like Progress in Neuro-Psychopharmacology & Biological Psychiatry, Life Sciences, Natural Product Radiance, Indian Journal of Pharmaceutical Sciences and many more.  Have been an external expert to a number of students for their Ph.D. defence and M. ……………………………………………………………………………………………………………

Source: http://www.niperahm.edu.in/pdf/perd-cv/dr-manish.pdf