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Calculating the cc’s LEARNING THE FORMULA
Now that the first two steps of this formula have been learned—identifyingand calculating the desired dose, and calculating the concentration—we canproceed to the third step. STEP 3
Calculate the amount of cc’s to be delivered.There are two purposes for this particular calculation: (1) when giving a drug through SQ, IM, IV, ET, or IO it is necessary to calculate the amount of cc’s to be drawn from a particular container (ampule or vial) or to be pushed through a prefilled syringe so that the desired dose can be delivered, or (2) to calculate the amount of cc’s needed to figure gtts/min, which is required in step 4, on calculating drip rates. For whichever reason cc’s are being calculated, the formula is:
If the route of administration is SQ, IM, ET, IO push, or IVP, only the
first three steps of this formula, (1) DD, (2) C, and (3) DD/C, need to becalculated, eliminating step 4, which is defined in chapter 4. The reason for
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eliminating step 4 when the route of administration is SQ, IM, ET, IO push,or IVP is that ultimately you need to calculate only the number of cc’s to drawfrom a given container, not the drops per minute, as required for a dripadministration. If a prefilled syringe is being used, it is necessary to calculateonly the number of cc’s to push from the syringe.
This step can be very simple because all it involves is dividing the desired
When dealing with this step, many times there are several zeros in these
To simplify the division process in the above example, some zeros can
be canceled out. When canceling zeros, the same number of zeros must be canceled in both the numerator (top number) and denominator (bottom number). See example:
In the above example, one zero was able to be canceled in both the nu-
merator of 500 and the denominator of 50. Another example of canceling out zeros follows:
In this last example, two zeros were able to be canceled in both the
Because zeros can be canceled out, measurements also can be canceled.
After canceling the mg’s, the only measurement left is cc. So the answer
will be in cc’s, as noted in the previous example.
Following are a few examples on the calculations involved in step 3.
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You have been ordered to give 2.5 mg of valium. On hand is a vial
with 2 cc containing 10 mg. How many cc’s would you draw?
DD ϭ 2.5 mg
Explanation: First you identified the desired dose, which was 2.5 mg. Then, in step 2, you calculated the concentration by dividing 10 mg by 2 cc (remember, mg over cc [mg/cc] when calculating the concentration), leaving 5 mg/cc. Then, in step 3, the desired dose of 2.5 mg was divided by the con- centration of 5 mg/cc. So 2.5 mg divided by 5 mg/cc equals .5 cc (remember that the mg’s canceled), leaving cc as the only measurement.
You have been ordered to give 1 mg/kg of Lidocaine IV. Your patient
weighs 150 pounds. The prefilled syringe contains 100 mg in 5 cc. How many cc’s will you push?
DD = 1 mg/kg 2.2 ͤ1500 68 * 1 mg = 68 mg
DD ϭ 68 mg
Explanation: In the previous example, the desired dose was ordered per
kg. So, first the pounds were converted to kg (by dividing the 150 pounds by 2.2), leaving an answer of 68 kg. You then multiplied the total number of kg, which was 68, by the desired dose per kg, which was 1 mg per kg, leaving a desired dose of 68 mg. In step 2, you calculated the concentration by dividing the number of mg’s by the number of cc’s of the on-hand drug, which was supplied in a pre- filled syringe. In step 3, you divided the desired dose by the concentration. The mg’s canceled out, leaving you with 3.4 cc to push from the prefilled syringe.
The physician has ordered 20 mg of Lasix IV. On hand is a vial with 4 cc containing 40 mg. How many cc’s will you give?
DD ϭ 20 mg
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Explanation: First you identified the desired dose of 20 mg. In step 2,
you took your on-hand medication supplied in the vial and divided the mg’s by the cc’s. In step 3, you divided the desired dose by the concentration. The mg’s canceled, leaving an answer of 2 cc. This amount would then be drawn from the vial and administered to your patient. THE TIME FACTOR
Note that when a drip has been indicated for a particular drug administra- tion, the desired dose will be ordered over a certain time frame, normally per minute. See examples:
10 g/kg/min
You should never leave out any part of the problem to “cut corners”
when calculating on paper. Consistently label each number or figure accord- ingly. See examples: DD ϭ 2 mg/min C ϭ 4 mg/cc DD ϭ 10 g/kg/min C ϭ 800 g/cc
Never leave out any measurements or time factors. Failure to include
any identifying factors, such as DD ؍, C ؍, DD/C ؍, mg’s, cc’s, or minutes,will only confuse and complicate the calculation learning process.
Concerning step 3 of this formula on calculating cc’s, if a time factor has
been given in the desired dose, be sure to always include it throughout each step, especially this one. But don’t let the time factor confuse you, because it has absolutely nothing to do with the calculation of this step. However, it has everything to do with step 4. This is why it is so important not to leave this factor out at any time throughout your calculations.
Again, be sure to place it (min) properly in the equation, but disregard
it when figuring your math through step 3. See example:
DD ϭ 2 mg/min .5 cc/min
In reference to the preceding example, cc’s is the only measurement left
after canceling the mg’s. The time factor always goes on the bottom of any answer throughout any equation. See example:
1Top2 2 mg/min (bottom) ϭ (Top) .5 cc/min (bottom)
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Since the minute is part of the desired dose, it must remain with the
desired dose, as noted in 2 mg/min, until you have calculated the answer in step 3 of the formula.The time factor then moves to the bottom in the answer in step 3, as shown previously in .5 cc/min.
When calculating cc’s to further be used in the calculation of step 4, your
answer will usually involve decimal fractions, especially in drips such as Dopamine. When this is the case, it is necessary that you divide only to the nearest 1000th, which is the third decimal fraction (.222). Rounding off to the nearest whole number is not suggested at this point when working with drip calculations. See examples:
= .187 cc/min DD =
= .212 cc/min SUMMARY
Just as you have learned, the third step of this process consists simply of dividing the desired dose by the concentration. Always remember to label figures and equations and don’t “cut corners.” This will only confuse you. So far, three of the four steps consists of: C (always weight/cc)
e.g.—mg/cc
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Following are a few practice questions pertaining to step 3. Simply completethe first three steps of the formula that you have learned so far. Remember,some of the answers may seem obvious to you, but it would be very much toyour advantage to work out each and every step.
An order has been given for a particular drip delivering 10 g/min. On hand is 1 mg, a 250 cc bag of fluid, and a minidrip administration set. How many cc’s per minute must be delivered to give the DD?
You have been ordered to give 8 mg of Decadron IV. On hand, you have a 5 cc vial containing 20 mg. How many cc’s must you draw to give your DD?
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A physician has given you an order for a Lidocaine drip to be run at 2 mg/min. On hand are two grams of Lidocaine, a 500 cc bag of normal saline, and a minidrip administration set. How many cc’s per minute must be delivered to give the DD?
The doctor has ordered you to give 25 mg of diphenhydramine IV. On hand is a 2 cc vial containing 50 mg. How many cc’s must you draw to give the DD?
You are at the residence of a patient who requires a dopamine drip. Your protocol states to give 2 g/kg/min. Your patient weighs 220 pounds. On hand is 400 mg of dopamine, a 500 cc bag of normal saline, and a minidrip administration set. How many cc’s per minute must be delivered in order to give the DD?
You are on scene with a 1-year-old male requiring 1 mg/kg of Lidocaine IV. The mother advises you that her son weighs 22 pounds. Your Lido- caine comes supplied in a prefilled syringe containing 100 mg in 5 ml. How many ml’s would you administer?
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You have been ordered to give 12 mg of Decadron IV. On hand is a vial containing 20 mg in 5 cc. How many cc’s would you give?
You are en route to the hospital and your patient requires 6 mg of adenosine rapid IVP. On hand is a 2 cc vial containing 6 mg. How many cc’s would you draw?
A dopamine drip has been ordered to be run at 8 g/kg/min. On hand is a vial containing 400 mg, a 250 cc bag of normal saline, and a minidrip. If your patient’s weight is 145 pounds, how many cc’s per minute would you deliver?
A Lidocaine drip has been ordered to be run at 3 mg/min. On hand you have a vial containing 1 gm, a 250 cc bag of normal saline, and a minidrip. If your patient weighs 220 pounds, how many cc’s per minute do you need to give?
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DD ϭ 10 g/min
C ϭ 1 mg/250 cc ¡ 1 0 0 0 g/250 cc ϭ 4 g/cc
= 2.5cc/min
C ϭ 20 mg/5 cc ϭ 4 mg/cc
DD ϭ 2 mg/min
C ϭ 2 gm/500 cc ¡ 2 0 0 0 mg/500 cc ϭ 4 mg/cc
= .5 cc/min
DD ϭ 25 mg
C ϭ 50 mg/2 cc ϭ 25 mg/cc
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DD = 2 g/kg/min ¡ 2.2 ͤ2200
DD ϭ 200 µg/min
C = 400 mg/500 cc = .8 mg/cc
¡ .8 mg ¡ 8 0 0. µg ϭ 800 µg/cc
= .25 cc/min
DD = 1 mg/kg ¡ 2.2 ͤ220 ¡ 10 * 1 mg = 10mg
C ϭ 100 mg/5 ml ϭ 20 mg/ml
DD ϭ 12 mg
C ϭ 20 mg/5 cc ϭ 4 mg/cc
C ϭ 6 mg/2 cc ϭ 3 mg/cc
65.9 ¡ 66 kg
DD = 8 g/kg/min ¡ 2.2 ͤ1450
DD ϭ 528 µg/min
C = 400 mg/250 cc ϭ 1.6 mg/cc
1.6 mg ¡ 1 6 0 0. g ϭ 1600 g/cc
= .33cc /min 10. STEP 1
DD ϭ 3 mg/min
C ϭ 1 gm/250 cc ¡ 1 0 0 0 mg/250 cc ϭ 4 mg/cc
= .75cc/min

Congenital Cardiac Abnormalities S i m u l a t e d C l i n i c a l E x p e r i e n c e ( S C E ™ ) O v e r v i e w L e a r n i n g O b j e c t i v e s Location: General Pediatrics Unit 1. Uses history and assessment fi ndings to plan, prioritize, and provide developmentally appropriate care to the infant patient with Down History/Information: syndrome (trisomy 21) and congeni

Progress in Neuro-Psychopharmacology & Biological Psychiatry 30 (2006) 112 – 119Effects of m-CPP and mesulergine on dietary choices in deprived rats:Spyridon Antonatos *, Panagiota GalanopoulouDepartment of Experimental Pharmacology, Medical School, University of Athens, 75, M. Asias, str, Athens 11527, Goudi, GreeceAlthough it has been well established that compounds that stimulat