Hypertension and microalbuminuria in hiv infected patients: beneficial effects of the treatment with telmisartan
Ucciferri et al. Retrovirology 2010, 7(Suppl 1):P64http://www.retrovirology.com/content/7/S1/P64
Hypertension and microalbuminuria in HIVinfected patients: beneficial effects of thetreatment with telmisartan
Claudio Ucciferri*, Paola Mancino, Katia Falasca, Francesca Vignale, Jacopo Vecchiet
From 16th International Symposium on HIV and Emerging Infectious DiseasesMarseille, France. 24-26 March 2010
statistically decreased at T1 (p = 0,006) and further on
In HIV infected patients there is increasing evidence of
T6 (p = 0,0001), whereas MDRD-GFR was statistically
hypertension and microalbuminuria, two important risk
augmented (p = 0,03). Cystatin-C, endothelin-1 and
factors for renal and cardiovascular disease (CVD). Anti-
VEGF were statistically reduced at T3 (p = 0,0001; p =
hypertensive drugs inhibiting the renin-angiotensin sys-
0,01 and p = 0,0045 respectively) and at T6. TG, TCh,
tem exert an antiproteinuric effect. Telmisartan, an
LDL-C levels decreased with statistical significance at
angiotensin II receptor blocker partial agonist of the
T6 (p = 0,003; p = 0,03 and p = 0,02 respectively), while
PPAR-g approved for the treatment of hypertension,
HDL-C increased at T6 (p = 0,04). ESR, PCR and IL-18
seems to exert a nephro-protective effect independent of
decreased at T6 (p = 0,04; p = 0,006 and p = 0,02
blood pressure reduction in the general population. Aim
of the study was to evaluate kidney-protective effects oftelmisartan
Telmisartan was well tolerated and effective to improvehypertension and lipid metabolism. Decreased microal-
buminuria and cystatin-C with increased MDRD-GFR
8 Caucasian male HIV+ patients cART treated without
are indicative of nephro-protective effects of telmisartan.
therapeutic changes for over 12 months and recent diag-
Mechanisms causing microalbuminuria in HIV+ patients
nosis of mild hypertension, were treated with telmisar-
could be related to infection, chronic inflammation and
tan 80 mg daily. They had suppressed viremia and CD4
endothelial dysfunction. Decreased endothelin-1 and
cell count > 300 cell/ml up on 6 month, and microalbu-
VEGF in this study may be related to an endothelial
minuria >5 mg/l. Systolic (SBP) and diastolic (DBP)
protective effect of telmisartan. These data confirm
blood pressure, triglycerides (TGs), total cholesterol
renal and endothelial protective effects of telmisartan
(TCh), HDL (HDL-C) and LDL (LDL-C) cholesterol,
CRP, ESR, microalbuminuria, MDRD-GFR, cystatin-C,IL-18, VEGF and endothelin-1 were measured at base-
line (T0), one (T1), three (T3) and six months (T6). Allthe statistical analysis was performed with the SPSSAdvanced Statistical 7.5 Software.
doi:10.1186/1742-4690-7-S1-P64Cite this article as: Ucciferri et al.: Hypertension and microalbuminuria
in HIV infected patients: beneficial effects of the treatment with
Treatment with telmisartan improved SBP and DBP
telmisartan. Retrovirology 2010 7(Suppl 1):P64.
values at T1 yet (p = 0,001). Microalbuminuria were
* Correspondence: Infectious Disease Clinic, Department of Medicine and Science of Aging, “G. d’Annunzio” University, Chieti, Italy
2010 Ucciferri et al; licensee BioMed Central Ltd.
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