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CoEnzyme Q10 Research Studies Summaries
This paper summarizes only a few of the many hundreds of scientific studies completed on CoQ10.
Heart Attacks
In a small trial of patients with recent myocardial infarction, Coenzyme
Q10…decreased the likelihood of further cardiac events for at least one
year after the heart attack. The dosage of Coenzyme Q10 used in the study
was 60 mg twice daily. Effect of coenzyme Q10 on risk of atherosclerosis in patients with recent myocardial infarction, Singh RB,. Mol Cell Biochem. 2003, Medical Hospital and Research Centre, Moradabad, India In a randomized, double-blind, controlled trial, the effects of oral treatment with CoQ10, 120 mg/day, were compared for 1 year, on the risk factors of atherosclerosis, in 73 (coenzyme Q10, group A) and 71 (B vitamin group B) patients after acute myocardial infarction (AMI). After 1 year, total cardiac
events including non-fatal infarction and cardiac deaths were
significantly lower in the intervention group compared to control group.
Heart Failure
Coenzyme Q10 improves the functional capacity of patients with chronic heart
failure, along with strengthening of their heart. Dr. Romualdo Belardinelli, of Lancisi Heart Institute, Italy, and colleagues, European Heart Journal, November 2006 They studied 23 patients, average age 59 years, with moderate to severe heart failure. They were assigned to 4 weeks each of oral Coenzyme Q10 supplements or inactive placebo pills, with or without supervised exercise training five times per week. Supplementation with Coenzyme Q10 led to a significant 3
percent increase in HDL ("good") cholesterol and improvement in peak
exercise capacity. There was an increase in cardiac function with
Coenzyme Q10 treatment. Combining exercise training with CoQ10
produced more marked improvements in these and all other
parameters.

Coenzyme Q10 in patients with end-stage heart failure awaiting cardiac
transplantation: a randomized, placebo-controlled study. Berman M, Erman A,
Ben-Gal T, Heart-Lung Transplant Unit, Rabin Medical Center, Beilinson Campus, Potah Tikva, Israel, Clin Cardiol. 2004 Studies have shown that coenzyme Q10 (CoQ10) has a beneficial effect on patients with heart failure. The purpose of the present double-blind, placebo- controlled, randomized study was to assess the effect of coenzyme Q10 on patients with end-stage heart failure and to determine if coenzyme Q10 can improve the pharmacological bridge to heart transplantation. A prospective double-blind design was used. Thirty-two patients with end-stage heart failure awaiting heart transplantation were randomly allocated to receive either 60 mg coenzyme Q10 (special preparation to increase intestinal absorption) or placebo for 3 months. All patients continued their regular medication regimen. Assessments included anamnesis with an extended questionnaire based partially on the Minnesota Living with Heart Failure Questionnaire, 6-min walk test, blood tests for atrial natriuretic factor (ANF) and tumor necrosis factor (TNF), and echocardiography…The administration of coenzyme Q10 to heart
transplant candidates led to a significant improvement in functional
status, clinical symptoms, and quality of life. Coenzyme Q10 may serve as
an optional addition to the pharmacologic armamentarium of patients with end-

High blood pressure, hypertension
Coenzyme Q10 may help lower blood pressure by a small amount. Randomized, double-blind, placebo-controlled trial of coenzyme Q10 in isolated systolic hypertension, South Med J. 2001 Systemic hypertension affects more than 50 million adults and is one of the most common risk factors for cardiovascular morbidity and mortality. This study evaluates the antihypertensive effectiveness of oral coenzyme Q10, an over-the-counter nutritional supplement, in a cohort of 46 men and 37 women with isolated systolic hypertension. We conducted a 12-week randomized, double- blind, placebo-controlled trial with twice daily administration of 60 mg of oral coenzyme Q10 and determination of plasma coenzyme Q10 levels before and after the 12 weeks of treatment. The mean reduction in systolic blood pressure of the coenzyme Q10 -treated group was 17 +/- 7.3 mm Hg. None of the patients exhibited orthostatic blood pressure changes. Our results suggest
coenzyme Q10 may be safely offered to hypertensive patients as an
alternative treatment option.

Statin drug and coenzyme q10 deficiency
Am J Cardiol 2007 There are some severe side effects from statin drug use. Statin drugs can cause muscle pain and damage, and Coenzyme Q10 could be helpful. Statin drugs, such as Lipitor and Zocor, lower cholesterol levels, but at the same time they interfere with the making of coenzyme Q10 in the body. Scientists now suspect that Coenzyme Q10 deficiency as a result of statin drug use may partly, or fully, contribute to the development of muscle damage. Dr. Giuseppe Caso and colleagues from Stony Brook University, Stony Brook, New York gave 100 mg of Coenzyme Q10 for one month to 32 patients using statins. Pain intensity decreased by 40% after a month of Coenzyme Q10 treatment whereas patients treated with vitamin E (as placebo) experienced no change in pain intensity. Sixteen of 18 coenzyme Q10-treated patients experienced a decrease Atorvastatin decreases the Coenzyme Q10 level in the blood of patients at risk for cardiovascular disease and stroke, Rundek T. Columbia University College of Physicians & Surgeons, New York, NY 10032, USA, Arch Neurol. 2004 Statins are widely used for the treatment of hypercholesterolemia and coronary heart disease and for the prevention of stroke. There have been various adverse effects. These adverse effects may be due to a Coenzyme Q10 deficiency because inhibition of cholesterol biosynthesis also inhibits the synthesis of Coenzyme Q10. OBJECTIVE: To measure Coenzyme Q10 levels in blood from subjects before and after exposure to atorvastatin calcium, 80 mg/d, for 14 and
30 days. Even brief exposure to atorvastatin causes a marked decrease
in blood Coenzyme Q10 concentration.
Alzheimer's disease, amyloid
Neuroprotective effect of Coenzyme Q10 on ischemic hemisphere in aged mice with mutations in the amyloid precursor protein, Neurobiol Aging 2006 This study was designed to test whether Coenzyme Q10 supplementation has
neuroprotective effect . We conclude that Coenzyme Q10 has a protective
effect on the brain from infarction and atrophy induced by ischemic
injury in aged and susceptible transgenic mice.
Anti-aging and longevity
J Gerontol A Biol, Sci Med Sci. 2005
Coenzyme Q10 protects from aging-related oxidative stress and
improves mitochondrial function in heart of rats fed a polyunsaturated
fatty acid (PUFA)-rich diet

Diabetes
Coenzyme Q10 may be beneficial in diabetics. It helps improve the function of
endothelial cells lining blood vessels and may slightly help with blood sugar
control.

Watts GF, et al. Coenzyme Q10 improves endothelial dysfunction of the
brachial artery in Type II diabetes mellitus.

Exercise and physical activity
The Effects Of Coenzyme Q10 Supplementation on Performance During
Repeated Bouts of Supramaximal Exercise in Sedentary Men, J Strength Cond Res. 2009 The objective of this study was to determine the effects of oral coenzyme Q10 (CoQ10) supplementation on performance during repeated bouts of supramaximal exercise. This randomized, double-blind, crossover study was composed of two 8-week periods of supplementation with either 100 mg.d CoQ10 or placebo. Fifteen healthy and sedentary men participated in the study. According to our results, CoQ10 may show performance-enhancing
effects during the repeated bouts of supramaximal exercises and CoQ10 might
be used as ergogenic aid.

Migraines
Efficacy of coenzyme Q10 in migraine prophylaxis: a randomized controlled trial, Neurology. 2005. Riboflavin, which improves energy metabolism similarly to coenzyme Q10, is effective in migraine prophylaxis. We compared Coenzyme Q10 (3 x 100 mg/day) and placebo in 42 migraine patients in a double-blind, randomized, placebo-controlled trial. Coenzyme Q10 was superior to placebo for attack-
frequency, headache-days and days-with-nausea in the third treatment
month and well tolerated; 50%-responder-rate for attack frequency was
14.4% for placebo and 47.6% for Coenzyme Q10 (number-needed-to-treat: 3).
Coenzyme Q10 is efficacious and well tolerated.

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