Executive internet pharmacy in Sydney where you can buy propecia australia online. Para compra cialis puede ser visto como un desafío. Aumenta Smomenta, y todos los que se poco a poco abrumado, como es lógico, cada vez más hombres están diagnosticados con disfunción eréctil.

Doi:10.1016/s0140-6736(07)61816-9

Health outcomes of bereavement
Margaret Stroebe, Henk Schut, Wolfgang Stroebe Lancet 2007; 370: 1960–73
In this Review, we look at the relation between bereavement and physical and mental health. Although grief is not a
Research Institute for
disease and most people adjust without professional psychological intervention, bereavement is associated with
Psychology and Health,
excess risk of mortality, particularly in the early weeks and months after loss. It is related to decrements in physical
Utrecht University, Utrecht,
health, indicated by presence of symptoms and illnesses, and use of medical services. Furthermore, bereaved
Netherlands (M Stroebe PhD,
individuals report diverse psychological reactions. For a few people, mental disorders or complications in the grieving
process ensue. We summarise research on risk factors that increase vulnerability of some bereaved individuals.
Diverse factors (circumstances of death, intrapersonal and interpersonal variables, ways of coping) are likely to
co-determine excesses in ill-health. We also assess the eff ectiveness of psychological intervention programmes.
Intervention should be targeted at high-risk people and those with complicated grief or bereavement-related
depression and stress disorders.
M.S.Stroebe@UU.NL
Introduction
physical eff ects does loss of a loved person have on Research on stressful life-events has progressed during survivors? Is the risk of succumbing to health disorders the past three decades, from study of the cumulative eff ect greater in bereaved than non-bereaved counterparts? We of life-events (measured with scales such as the social try to establish prevalence of health outcomes, identifying readjustment rating scale [SRRS])8 to a focus on specifi c subgroups that are especially vulnerable. Furthermore, life-events, such as bereavement. Death of a spouse ranks we review studies on the eff ectiveness of psychological as the life-event needing the most intense readjustment intervention programmes in reducing the risk of negative on the SRRS, confi rming the status of bereavement as a health issues in bereaved individuals, asking a third highly stressful event. Much research has been undertaken question: Can counsellors and therapists help to reduce on bereavement, defi ned as the situation of having the health problems of bereaved people?
recently lost a signifi cant person through death.3 Although
comparatively rare in childhood, bereavement is a The mortality of bereavement
life-event that, sooner or later, becomes part of nearly Overall patterns
everyone’s experience. Of children younger than 18 years,
For several decades, researchers have examined whether 3·4% have experienced the death of a parent,9 whereas in the death of a loved one increases the mortality risk of elderly populations, spousal bereavement is most the bereaved person—understood popularly as dying of frequent, with about 45% of women and 15% of men a broken heart. The most valid and reliable information older than 65 years becoming widowed.10 As such, is provided in longitudinal investigations comparing bereavement can be viewed as a normal, natural human bereaved with non-bereaved counterparts, controlling experience, one which most people manage to come to for several confounders12 such as socioeconomic and terms with over the course of time. Nevertheless, it is lifestyle factors the bereaved spouse would have shared associated with a period of intense suff ering for most with their deceased partner, which could aff ect the individuals, with an increased risk of developing mental bereaved spouse’s health as well. Other potential and physical health problems. Adjustment can take confounders include cases of deaths from accidents months or even years and is subject to substantial involving both spouses (where one outlives the other variation between individuals and across cultures. For a and becomes categorised as widowed—thereby few people, mental and physical ill-health is extreme and increasing the number of deaths of widows that are persistent. For this reason, bereavement is a concern not unrelated to the bereavement) and selection into only for preventive care but also for clinical practice. remarriage of the healthiest widowed individuals Grief is defi ned as the mainly emotional reaction to bereavement, incorporating diverse psychological and physical reactions.3 Over the past few decades, scientifi c Search strategy and selection criteria
study of the symptoms, mental and physical health We searched PubMed, Medline, and PsycINFO with the terms outcomes, and ways of coping with grief has expanded “bereavement” and “grief” for reports published after 1997. rapidly.3,11 This research seeks to develop ways to identify When selecting reports for inclusion, we gave priority to: and provide preventive care for individuals at risk for recent studies; those meeting quality criteria (sample size, bereavement-related health problems. The current state response rate, use of standardised measurements, analytical of knowledge with respect to the consequences of techniques, etc); those that included a control group of non- bereavement and care of bereaved people is the focus of bereaved individuals (where appropriate); prospective studies this Review. We review scientifi c published work on the (before or after a death); and longitudinal studies. We also mental and physical health outcomes of bereavement. We referred to our previous publications.1–7 address two basic questions. What psychological and www.thelancet.com Vol 370 December 8, 2007
Reference/location
Sample characteristics
Follow-up Findings
(years)

Men who had lost partner by suicide had relative risk of suicide of 46·2 Relatives of n=9011 who committed suicide, (95% CI 1·3–116·4) and risk of mortality by other causes of 10·1 (6·5–15·8) Women’s risks were 15·8 (6·6–37·4) and 3·3 (1·5–7·2), respectively Child bereavement by suicide or other causes imposed about a two-fold increased risk in parents Early excess mortality for widowers older than 74 years, no other Widows of men aged >64 years, widowers of women Spouses whose partners spent time in hospital before death Hazard ratio for widowers=1·21 (95% CI 1·19–1·22), for widows=1·17 Widows=252 557, widowers=156 004 aged >65 years (115–1·19) compared with people with a living spouseVery high increased risk in fi rst 30 days after bereavement Excess mortality seen in white but not black widowers and widows 86 323 widowers, 176 671 widows aged older than 65 years (similar in both sexes), especially in the fi rst month, but remaining raised over many years n=2323 (deaths from suicides, widowed vs other marital Signifi cant increase in suicide risk during fi rst year of bereavement, In absolute terms, oldest men had highest increase in suicide risk immediately after loss (15-fold > than middle-aged still-married men) Being widowed had no signifi cant eff ect on suicide risk Longitudinal survey of 50 000 households, 545 suicidesMales and females, age 15 years and older Suicide risk for widowers was 3·3 times as high as for married men Parents of children who died at age <18 years Overall increased mortality from natural and unnatural causes in Early increased mortality from unnatural causes in fathers Bereavement was a mortality risk factor for both men and women, n=1993 pairs of twins, one widowed, the other still married higher for the “young-old”(age <70 years) and for those recently widowedDecrease in risk of death after 4 years of bereavement in “young-old” widows (age <70 years) compared with married women Risk of dying for widowed individuals was signifi cantly higher than for married people (among both blacks and whites), but this risk was accounted for by deaths among widowersWidows’ risks were similar to those of married women Excess mortality for both bereaved men and women, especially with n=4420 bereaved men, n=11 114 bereaved women; n=49 566 short duration of bereavement (during fi rst 6 months, during which time excess mortality was 40% for men, 50% for women) Excess mortality was 17% in men, 6% in women n=22 294 men, n=61 686 women, from n=1 580 000 married Higher risk for shorter than longer durations of bereavement Increase of about 75–100% in risk of mortality in fi rst 6 months in n=237 widowed from a cohort of 1046 married elderly widowers, but results not statistically signifi cant due to limited power of the study Higher risk in widows than widowers (age 65–74 years) Parents completing suicide n=18 611, controls n=372 220 Both fathers and mothers (similar excess rates) had raised suicide risk (greater than other causes) after death of a child, especially after younger child loss and in fi rst month of bereavement Raised relative risk in both sexes, particularly during second half of fi rst n=1453 men, n=3294 women bereaved in cohort of n=12 522 In men, risk decreased after 24 months but remained high over years after bereavementIn women, eff ects were restricted mostly to fi rst year Younger (<65 years old) widowers’ rates were raised when wife died n=141 men, n=351 women, n=1782 married controls suddenly (at 6 months or less onset of disease) Older (>64 years old) widows’ rates were lower when husband died of long-term illness Cross-sectional surveys, including national or other large-scale ones, are omitted from table 1 because even if they introduce controls for confounding factors, they do not have information on the duration of bereavement at death. Compared with individuals who have not been bereaved, cross-sectional surveys typically fi nd patterns of high mortality in widowed people. They also fi nd higher mortality in widowers compared with widows, and in younger compared with old widowed individuals (likewise, when the ratios are compared with non-bereaved individuals).
Table 1: Mortality of bereavement
www.thelancet.com Vol 370 December 8, 2007
(therefore the individuals left in the widow group tend to duration of bereavement. Excess mortality in widowed be the least healthy and more vulnerable to mortality).
populations is highest in the early months, and Table 1 presents an overview of fi ndings of longitudinal decreases with increasing duration of bereavement.24 studies published since our 1993 review12 on the Martikainen and Valkonen24 reported higher rates for mortality of bereavement. Nearly all reports have been widows and widowers compared with married people: of spousal bereavement, partly because these statistics mortality was very high for accidental and violent causes are somewhat easier for researchers to access than and alcohol-related diseases, moderate for chronic other data but also because this type of bereavement is ischaemic heart disease and lung cancer, and small for fairly common (compared with child loss) and has a other causes of death. Of bereaved parents, excess risk great personal eff ect (compared with parental loss in of mortality for mothers has been seen to extend for adulthood). Most of the fi ndings indicate an early ex- 18 years in one study, with deaths attributable to natural cess risk of mortality,21,23–25,27 although some researchers and unnatural causes, whereas for fathers, greater risk have also noted risks persisting for longer than 6 months was noted early on in bereavement from unnatural As seen in table 1, several longitudinal studies have Subgroup diff erences
focused specifi cally on the risk that bereaved people will Importantly, in some studies, researchers have take their own lives, with most investigations fi nd ing examined subgroup diff erences—eg, sex and age excess mortality.13,17,20,28,32,33 Kaprio and col patterns, education and ethnic origin, household size example, noted large excess mortality in the fi rst week and number of children. For example, a controlled, of bereavement: 66-fold for widowers and 9·6-fold for large-scale study16 reported a greater risk of widows. In some of the other studies included in table 1, bereavement-related mortality in white people than in analyses by suicide were also reported.20 In general, black people. Sex and age patterns have been recorded these fi ndings confi rmed the pattern of excess mortality most frequently. Generally most, though not all,15 seen in the suicide-specifi c studies listed. In some cases, fi ndings confi rm that there are sex diff erences in the studies have included analysis of the person whose mortality of spousal bereavement (table 1):4 widowers death had been the cause of bereavement.13 Agerbo13 (compared with married same-sex counterparts) are at noted that death by suicide increased the suicide risk for relatively more excessive risk of mortality than widows bereaved widowers and parents even more than other (compared with married same-sex counterparts). That causes.
widowers with poor health tend not to remarry does not account for the diff erences in mortality. That Conclusions
sex-diff erence patterns can vary across types of loss (eg, Bereavement is associated with an increased risk of spousal, child, parent) is noteworthy. Death of a child mortality from many causes, including suicide. In has been reported to have an even greater eff ect on published studies, confounders have been well-controlled, mothers than fathers.19 Furthermore, patterns of and patterns are quite consistent, enabling the conclusion mortality by sex in bereaved people could be altering that the mortality of bereavement is attributable in large with changing sex roles in recent decades. part to a so-called broken heart (ie, psychological distress With respect to age, fi ndings of studies have also in di- due to the loss, such as loneliness34 and secondary cated a greater mortality risk for younger than for older consequences of the loss, such as changes in social ties, be reaved people who have lost their spouse,24,29 confi rm- living arrangements, eating habits and economic ing earlier reported patterns.12 This eff ect might be support35). For widowers, the increased risk will probably more pronounced for widowers than for widows.23,30 be associated with alcohol consumption and the loss of However, caution must be used in interpretation of age their sole confi dante, who would have overseen her diff erences in the mortality of bereavement.10 For husband’s health status.4 Some evidence is available that example, institutionalised individuals (ie, those in excess mortality rates extend beyond spousal loss, to prisons, nursing homes, juvenile detention facilities, or include parents (and possibly others too, such as residential mental hospitals) are sometimes excluded children). Individuals who have been bereaved for a short purposely from large-scale samples18 and rates for time are at greater risk of mortality than are those residential relocation increase on the death of a partner.31 bereaved for longer, although raised risk might persist Thus, those people who are very frail and whose (particularly from certain causes such as alcohol-related mortality risk is therefore high could be excluded from samples, thereby boosting the relative survival rates of Although mortality is a drastic outcome of losing a elderly populations compared with young people.
loved one, it must be assessed in terms of the absolute number of bereaved people who die. Baseline rates Causes of death
are low, with, for instance, about 5% of widowers Bereaved people die excessively from various causes, versus 3% of married men in the 55 years and older age which are, not surprisingly, diff erentially related to the category dying in the fi rst 6 months of bereavement.4 www.thelancet.com Vol 370 December 8, 2007
Physical ill health
rence of pain in older widowed individuals, focus ing on General patterns
particular aspects (activity-limiting pain, strength of most Some investigators have reported a greater occurrence of severe pain, and current pain). Those bereaved for short physical health complaints in bereaved people (compared with matched controls), ranging from physical symptoms pain and moderate-to-severe current pain. In general, (eg, headaches, dizziness, indigestion, and chest pain) to compared with non-bereaved controls, widowed people high rates of disability and illness, greater use of medical were three times more likely to report having current services (in some studies), and drug use.1,35 Many surveys strong pain. The current level of mood disturbance have been undertaken cross-sectionally, thus researchers mediated the relation between widowhood and pain.
have not identifi ed recently bereaved people. Most studies Bereavement has also been associated with weight have been done with bereaved partners, although a few loss.35,41 Schulz and colleagues42 reported that, in general, have been undertaken for other types of loss. For example, individuals who had not undertaken caregiving of their Murphy and colleagues36 compared the health of mothers spouse before their death were more likely to have weight and fathers after the violent death of a child. They loss in bereavement. These people were also more likely recorded poorer physical health in mothers than in to be using non-tricyclic antidepressants. The researchers fathers, but unlike mothers, the health of fathers suggested that these patterns might be attributable to the deteriorated rather than improved over time (14% of unpredictable nature of the death. fathers rated their health as poor at 4 months after bereavement and 24% did so at 24 months). Conclusions
Some studies have included fi ndings across the wide People who have been bereaved are more likely to have range of physical ailments and illnesses, specifi cally for physical health problems, particularly those who have been recently bereaved spouses, comparing rates with longer bereaved recently. Bereaved individuals also have higher term bereaved and non-bereaved counterparts. In a rates of disability, medication use, and hospitalisation than classic study, Thompson and co-workers37 reported odds non-bereaved counterparts. Although widowed people in of a new or worsened illness in older bereaved spouses at general consult with doctors more frequently, most likely 2 months after their loss, estimating these odds to be because of symptoms of anxiety and tension,35 fi ndings 1·40 times the risk of non-bereaved people. Similarly, suggest that many of those with intense grief might fail to self-reported medication use was higher among bereaved consult with doctors when they need to.
individuals (1·73 times greater), as were perceived current ill health and ratings on illness severity. Visits to Psychological symptoms and ill health
doctors were not increased in this elderly sample. By Psychological symptoms
6 months, most of these diff erences had declined.
Bereavement is also associated with various psychological The fi nding that visits to doctors were not increased in symptoms and illnesses;1,35 panel 1 provides an overview bereaved populations in the Thompson study37 is of common reactions.1,7 Neimeyer and Hogan have noteworthy. In a study of women who had been bereaved reviewed grief assessment methods.43 Psychological for about 4 months, Prigerson and colleagues38 noted that reactions are, generally speaking, most intense in early women who reported high intensities of grief had bereavement.35,44 Studies of individual psychological reduced use of health services for physical health reactions to bereavement, such as those listed in panel 1, disorders despite the fact that they had a signifi cantly have been undertaken by many researchers, including increased likelihood of high blood pressure and investigation of suicidal ideation,34,44–48 loneliness,49,50 and functional impairment compared with widows reporting insomnia.51 Other workers have identifi ed relations between grief-specifi c symptoms and depression, anxiety, The results suggest that bereaved individuals who are distress, somatic symptoms, insomnia, and social most in need of health care might not be obtaining such dysfunction at 6 months’ bereavement duration.39,44 help. The fi ndings of this investigation are particularly Researchers have also studied the similarities and worrisome in view of results of a pre-post bereavement diff erences between depression and grief,43,52–56 even at a investigation of hospital patients’ spouses.39 High physiological level.57 Growing evidence suggests that intensities of grief at an earlier point in the investigation depression and grief might represent distinct, though predicted severe physical health disorders (eg, cancer, related, clusters of reactions to bereavement.52,56heart attack) in bereaved individuals more than a year Bereavement is a harrowing experience for most people, one that causes considerable upset and disruption of everyday life. For most people the experience, though Specifi c debilitating aspects
cult, is tolerable and abates with time. For some, Other research groups have identifi ed additional however, the suff ering is intense and prolonged.
debilitating aspects of physical ill health in bereaved
Psychological reactions to bereavement are diverse,49,58 populations. For example, in a cross-sectional in varying between individuals as well as between cultures tigation, Bradbeer and colleagues40 examined the occur- and ethnic groups.59–61 Few well-controlled studies of www.thelancet.com Vol 370 December 8, 2007
cultural diff erences in bereavement have been done. A tisation of grief in non-western cultures.63 However, later study60 of qualitative interviews with bereaved studies do not support this notion. In a large-scale African-American individuals described unique international study, Simon and colleagues64 noted that characteristics of grief in that population, undermining cognitive and somatic symptoms were alike across general assumptions made about grief based on studies diverse cultures. Although patients’ experience of of white Americans. Generally, clinical experience and depression seemed to diff er little across cultures, accounts of grieving in specifi c societal and ethnic variation was evident in presenting symptoms. For groups suggest there are diff erences in cultural patterns example, at centres where depressed patients did not of grief and grieving, with some diff erences attributable have an ongoing relationship with a primary-care to religious beliefs. For example, Egyptian Muslims physician, a situation that is more common in express intense overt grief, but the Muslim community non-western settings, patients were more likely to in Bali does not; they avoid any display of grief such as present with somatic symptoms than were those who crying.62 had a personal physician. These results suggest that the Some studies of depression suggested the possibility diff erences in diff erent countries’ health care systems of cultural diff erences, specifi cally, increased soma- may play a role in how patients present as well as patients’ beliefs about the best way to seek help and have one’s troubles recognised. Nevertheless, it is likely that Panel 1: Reactions to bereavement
the fundamental manifestations of grief are universal.65 Aff ective
Reactions vary in nature and intensity according to the type of lost relationship. Scientifi c investigation has recorded specifi c reaction patterns to various diff erent types of bereavements. For example, uniquely, in the case of a child’s death, many bereaved grandparents feel enormous sadness and pain for their grieving adult child and a sense of generational survivor guilt.66 Studies have been done looking at a wide variety of bereavements, including loss of a parent in childhood or adolescence67–69 and in adulthood,70 the death of a child,71–73 perinatal loss,74,75 Cognitive
loss of a grandchild,66 or death of a friend.76 AIDS-related Preoccupation with thoughts of deceased, intrusive grief and coping—with a focus on gay communities—has also been a concern of scientifi c investigation in recent Changes during bereavement
Changes in symptoms of bereavement over time were originally described in terms of stages or phases of shock, yearning and protest, despair, and recovery,80 and lately in terms of tasks.81 This so-called task model is used in guiding counselling and therapy. The four tasks Behavioural
of grieving are: accepting reality of loss; experiencing the pain of grief; adjusting to the environment without the deceased; and relocating the deceased emotionally and moving on. We should note, however, that not all grieving individuals undertake these tasks, nor, if they do, do they undertake them in a fi xed order. Both individual and cultural diff erences may play a role. In addition, bereaved individuals are far from uniform in Physiological–somatic
their emotional reactions over time, leading some investigators to suggest that there are diff erent Energy loss, exhaustionSomatic complaints Resilience versus vulnerability
Researchers have reported that over the long-term, Immunological and endocrine changes
most bereaved people are resilient, recovering from Susceptibility to illness, disease, mortality their loss, emotionally and physically, with time.58,83 These claims are in line with general scientifi c opinion Adapted from references 1 and 7, with permission. that bereavement is a normal life event to which most www.thelancet.com Vol 370 December 8, 2007
people adjust.1,3,84 Depression is thought to be such a normal response to bereavement that the Diagnostic Panel 2: Criteria for complicated grief proposed for
and Statistical Manual of Mental Disorders, 4th edition85 Diagnostic and Statistical Manual of Mental Disorders,
excludes people bereaved for less than 2 months from 5th edition*96
the diagnosis of major depressive disorder. Although Criterion A
identifying what makes people susceptible to Chronic and disruptive yearning, pining, longing for the psychological disorders has a long research tradition, the problem of bereavement can also be approached by studying the factors that make people resilient. For Criterion B
example, researchers have focused on positive growth86 The individual must have four of the following eight or, more specifi cally (albeit with limited empirical remaining symptoms at least several times a day or to a evidence so far), on creativity that might come about as degree intense enough to be distressing and disruptive: a result of (early-life) bereavement.87 Thus some people gain from their bereavement experience.
3 Excessive bitterness or anger related to the death Psychiatric disorders
In general, most people have acute suff ering, particularly early on in bereavement.3,35,84 And for a few, symptoms for 6 Feeling life is empty or meaningless without deceased reactions listed in panel 1, such as depression or anxiety, can become clinically important.88 Many studies report an increase in depressive symptoms in bereaved Criterion C
populations.35 For a few people depression reaches The above symptom disturbance causes marked and clinical importance,88 with fi ndings of studies suggesting persistent dysfunction in social, occupational, or other that 25–45% have mild levels of depressive symptoms In some cases, especially when the loss of life has been Criterion D
massive or the nature of the deaths horrifi c, the bereaved The above symptom disturbance must last at least develop post-traumatic stress disorder.88,89 In a sample of bereaved parents 5 years after the death of their child, *For a diagnosis of complicated grief, A, B, C, and D criteria must be met. Reprinted 27·7% of mothers and 12·5% of fathers met diagnostic criteria for post-traumatic stress disorder compared with 9·5% women and 6·3% men in normative samples.90 inhibited grief. Prigerson and colleagues have used their Psychiatric morbidity increases after widowhood91 and analysis to develop diagnostic criteria for complicated bereaved parents have higher rates of psychiatric (prolonged) grief (panel 2). An alternative diagnostic morbidity than non-bereaved individuals.92 In a study by system in terms of a stress response model is presented Li and colleagues,92 mothers especially had high rates of by Horowitz and coworkers.99 Complicated grief has not fi rst psychiatric admission, particularly during the fi rst yet been classifi ed as a category of mental disorder in the year of bereavement. Of course, bereaved individuals can Diagnostic and Statistical Manual of Mental Disorders, have a combination of disorders, developing, for example, 4th edition,85 although eff orts are being made to have it both post-traumatic stress disorder and major depressive included as a separate category in forthcoming editions.100 disorder, further complicating their grief reaction.88,93 Estimates of the occurrence of complicated forms of grief vary across investigations and diagnostic criteria. Complications in the grieving process
For example, chronic grief has been reported to occur in In some cases, the grieving process can become complicated about 9% of a population of adults experiencing or disturbed, perhaps because of other mental-health bereavement,88 whereas 20% prevalence for complicated diffi culties.38,94–96 Complicated grief has been defi ned as a grief was recorded in another investigation.93 In a study of deviation from the normal (in cultural and societal terms) parents who had lost a child 18 months previously,101 as grief experience in either time course, intensity, or both, many as 78% of those bereaved by suicide or accidents entailing a chronic and more intense emotional experience and 58% by sudden infant death syndrome scored above or an inhibited response, which either lacks the usual a suggested cutoff level, using the Prigerson and Jacobs93 symptoms or in which onset of symptoms is delayed.3,35,97,98 criteria for complicated grief reactions. Such large Prigerson and Jacobs93 have suggested criteria for numbers might indicate high intensity of grief in parents complicated grief in terms of separation distress (eg, but, given the nature of the parent-child relationship, they preoccupation with thoughts of the deceased) and may not necessarily indicate pathological processes. This traumatic distress (eg, feelings of disbelief about the raises the question whether this cut-off point is a good death). Their construct of complicated (long-term) grief marker of chronic grief or whether norm scores for bears similarity to chronic grief while omitting delayed or www.thelancet.com Vol 370 December 8, 2007
Specifi c risk factor
Main fi ndings
Cause of death (including Inconsistent results for sudden vs expected deaths;111,112 traumatic deaths: worse outcomes;89,113 note also parents’ reactions to traumatic deaths.36,90 Sudden death likely to have the most eff ect on vulnerable people (eg, those with low self-esteem) and those who are personally less well-prepared114,115Few diff erences in eff ect of suicide or non-suicide deaths in some studies, but longer adaptation and some aspects (eg, stigmatisation, shame) more of an issue after suicide deaths than after other deaths.116 Excessive risk of mortality (including suicide) after suicide death.13 Suicide-bereaved children might be vulnerable117 Multiple (concurrent) losses;2 witnessing extreme distress in terminal illness increases eff ect of loss,118 but a so-called good death (eg, appropriate medical care, reducing distress for dying and bereaved) ameliorates the eff ect7,119 Rituals can help, particularly for children120Deaths with hospice care are sometimes (not always121) associated with better outcomes than deaths in hospital in bereaved people. Some evidence suggests that deaths in hospice care are associated with lower mortality rates in the bereaved.122 Death of a child in hospital is associated with more symptoms for parents than the death of a child at home123 Strain aff ects health of caregiver before and after bereavement, 7,42,124–126 although successful caregiving can be helpful, caregiving benefi ts might also be associated with high amounts of grief127 Health consequences not only owing to burden and responsibilities but also to personal neglect of one’s own health, nutrition, physical and emotional needs42 Death might on occasion be judged a relief for patient and bereaved128 Findings of a few studies show that kinship relationship moderates type of eff ect on health.129,130 Loss of a child (adult) associated with more intense and persistent grief and depression than loss of spouse131,132 Earlier claims that poor relationships (eg, ambivalence, dependency) lead to diffi culties in bereavement, some benefi ts from good relationships,95 but fi ndings not consistent concerning positive or negative outcomes and marital quality with respect to dependency, closeness, harmony, etc133–135 Concurrent stressors aff ect bereavement outcome, eg, fi nancial hardship that compounds diffi culties in adjustment. If bereavement is concurrent work and legal accompanied by a drop in economic resources, or insuffi cient income, eff ects of bereavement might be exacerbated.7,26,136 Poor eating habits and loss of weight compared with married people41 Intrapersonal risk or Personality or attachment Some protective factors identifi ed (eg, optimism,132,137 perceived control over daily activities,115 high self-esteem,115.138 secure attachment style in protective factors Pre-bereavement depression probably associated with high risk of intensifi cation of depression in bereavement88 Findings of most studies show early (childhood or adolescent) bereavement to be a risk for later (adulthood) mental and physical health issues;141–144 also noted are: cortisol concentration diff erences,142,143 information processing biases;145 diff erent sibling relationships.146 Adequacy of remaining parent care and personal characteristics of child are important141 Findings of some, but by no means all, studies show religion helps132,147–149 Socioeconomic status: fi ndings of some studies suggest that health outcomes of bereavement are not related to socioeconomic status (see also economic resources below).2,7 Some reports of poorer health in lower socioeconomic groups probably indicate non-bereavement-specifi c patterns.2 Relative mortality is similar across education and income groups but absolute diff erences compared with married people are greater in lower social strata25 Gender: widowers are relatively more vulnerable than widows;4,150,151 mothers are aff ected more than fathers19,152Age: young people are reported to be more vulnerable in some studies,7,84 curvilinear relations also noted153 Ethnic group: similarities in grieving recorded between black and white people; however, anger and despair are lower in black populations,134 and high rates of psychiatric disorders154 and mortality are seen in both black and white bereaved people (patterns of comparative sex diff erences are less clear).22 Diff ering ethnic groups also have unique features of grief60 Social support helps bereaved and non-bereaved individuals alike, but bereaved people with higher support are not comparatively better- adjusted than are those with low support, compared with non-bereaved counterparts5 Cultural and social embedding probably aff ects bereavement outcome60 Material resources (money; services) might buff er against extra stresses, but in general, eff ects of bereavement are broadly similar across income groups7,26 Grief work, sharing, and disclosure are not as predictive of outcome as has been previously claimed. Avoidance is not necessarily so detrimental, but rumination is associated with poor outcomes, whereas positive (re)appraisal is associated with good outcomes.5,52,77,137,155–159 Meaning making is regarded as benefi cial157,158 Regulation (confrontation or avoidance; positive and negative appraisals) in the grieving process is likely to be benefi cial52,59,160 Table 2: Potential risk or protective factors in bereavement
Conclusions
to extreme and long-lasting over the months or even years A wide range of psychological reactions are associated of bereavement.
with bereavement, causing researchers to regard grief as a complex emotional syndrome.102 Although some responses Additional medical implications
can be more symptomatic of grief than others, no one Bereavement can have an even broader range of response is essential to the syndrome. Furthermore, consequences than those already discussed. Bereavement reactions range from mild and comparatively short-lived has been shown to be associated with impaired memory www.thelancet.com Vol 370 December 8, 2007
performance,103 nutritional problems,104 work and relationships (eg, over-dependency vs typical dependency; relationship diffi culties concentrating; and lack of harmony vs autonomy) might shed light on apparent decreases in social participation.105,106 And health-care costs inconsistencies.133 Research on attachment strongly for bereaved individuals have been shown to be higher.11 supports the view that the quality or nature of the lost These health eff ects are likely to be associated with relationship has much eff ect on outcome.80,95,139,140changes in diff erent underlying physiological mechanisms. Intrapersonal resources and protective factors refer to A full discussion of these mechanisms is beyond the scope characteristics intrinsic to the bereaved individual. of this Review, however, research has begun to show Remarkably little research has been undertaken on these biological links between bereavement and increased risks aspects of personality, despite the fact that clinicians of physical illnesses. For example, research has been done assume that people with well-adjusted personalities would looking at how bereavement aff ects the immune system, be better able to deal with loss than those who are less leads to changes in the endocrine, autonomic nervous, well-adjusted.88 Findings of available studies support the and cardiovascular systems, and helps to account for view that robust individuals adjust to bereavement better increased vulnerability to external agents;2,3,107 how MRI than people who are fragile. These patterns are probably scans can be used to study the neuroanatomy of grief,108 related to attributional52 and emotional regulation and how autonomic and emotion regulation indicators processes.52,59,160 Atributions refer to the interpretations can been used to identify physiological diff erences with which people make sense of what is happening to between bereaved, depressed, and control individuals.109 them; emotion regulation processes refer to the strategies people use to modify aspects of their emotions. Research Risk factors
into such risk factors and the associated underlying Much research eff ort has been directed at identifi cation cognitive processes is incomplete. Further research is also of risk factors to understand why people are aff ected by needed on other predisposing vulnerabilities (eg, previous bereavement in diff erent ways; why some people have mental-health disorders, medical or physical health issues, extreme or lasting outcomes and others do not.110 age-related frailty, substance abuse), but childhood loss of Bereavement researchers use the term risk factor to a parent has been better researched, indicating various signify the situational and intrapersonal and interpersonal long-term eff ects. Importantly, evidence suggests that the characteristics associated with increased vulnerability to adequacy of remaining parental care (eg, warmth and the range of bereavement outcomes.110,111 Some researchers discipline) after the death of one parent, and personal have integrated into their analyses protective factors that characteristics of the child (ie, factors contributing to appear to promote resilience and to lower risk of adverse resilience) are more powerful predictors of later health outcomes.83 Indeed, research should incorporate adjustment than the loss of the parent per se.141,142 analyses of the coping process, which can impede or Of interpersonal factors, social support from others facilitate adjustment, to determine whether there are would generally be regarded as a major variable, buff ering healthy and unhealthy ways of going about grieving. individuals against the negative health outcomes of Table 2 categorises risk factors into four categories, bereavement. However, this assumption has not been indicating the scope of empirical research and providing well-founded empirically.5,161 Inadequate social support is some key fi ndings and references. Although some of the a general risk factor, one that aff ects the health and listed factors have been investigated empirically, others well-being of non-bereaved people as much as those who are suggested in clinical or qualitative published work and need further quantitative investigation. Furthermore, in some studies non-bereaved controls are omitted. Thus, whether the specifi c risk factor is general (present in Everyday life experience
non-bereaved people too) or bereavement-specifi c remains unclear.
There is considerable evidence that many of the variables Restoration-
listed under situation and circumstances of death orientated
orientated
contribute to diff erences in adjustment (although some work has yielded inconclusive or contradictory results). It is important, then, to take the broader circumstances of death, including cause of death and caregiver strain, into account and to realise the complex combination of personal and situational factors that account for the eff ect of
variables such as these. We noted in table 2 discrepancies
in fi ndings on quality of relationship to the deceased
(placed in this category since it bears on circumstances
and situation of death, but it is relevant to other categories
too). Further investigation of the various features of Figure: Dual process model of coping with bereavement160
www.thelancet.com Vol 370 December 8, 2007
Comments
Absence of eff ects possibly because nearly all studies used outreaching recruitment procedures (help off ered rather than asked for)171 More positive results than previous studies.78,79,173,174 Suggestions of better results seen in Positive results possibly because three of four studies were inreaching studies females (adults and young girls) than in young males.78,79,174 Better results in people with cacy for those with higher levels of mental-health mental-health problems at baseline, for both adults175 and children174,176 problems before intervention suggests rationale for secondary intervention Secondary
Generally, though not unequivocally, more eff ective than primary intervention, though eff ects Eff ectiveness associated with strict use of risk criteria, showing need to diff erentiate were modest and improvements were temporary more within groups and tailor intervention to the subgroup (eg, by gender181) Improvements in children bereaved by suicide in group intervention (compared with community care).177 Families at high-risk showed slightly more improvement after family-focused grief therapy178,179 in terms of general distress (not family functioning). Those with worst symptoms had most improvement. No eff ects of a highly-specifi c (body touching) therapy180 on bereaved mothers. Emotion-focused interventions most eff ective for distressed widowers; problem-focused for distressed widows.181 Fathers in general, and mothers with low baseline values of distress and grief did not benefi t from group intervention focused on problems and emotions; highly distressed or grieving mothers improved most through intervention182 Tertiary
Modest but lasting positive eff ects on symptoms of pathology and grief (individual and group Therapy for complicated grief or bereavement-related depression and stress interventions; from analytically oriented dynamic psychotherapy to cognitive and behaviour disorders has led to substantial and lasting results. 3 additional studies were cult to interpret (no non-intervention control group) but were interesting for future research.52,165,185,186 For example, gender diff erences in eff ects of time-limited Substantiate earlier fi ndings: strong eff ects in terms of intrusion, avoidance, grief, depression supportive and interpretative group therapy in bereaved people with major & anxiety.183,184 Assessed nortriptyline and interpersonal psychotherapy (alone and in depression: women improved more than men in depression, anxiety, avoidance combination) for people with bereavement-related major depressive episodes examined.184 and general distress; men reported less grief than women after interpretive group Nortriptyline led to less remission than placebo and psychotherapy. Indication that therapy.185 A specifi c individual treatment module for complicated grief was more combination of medication and psychotherapy gave best results eff ective than standard interpersonal psychotherapy165 Table 3: Eff ectiveness of bereavement intervention programmes: psychosocial and psychological counselling and therapy105,170
are bereaved, but others cannot easily take the place of directly with the loss, such as going over death events the deceased individual. Use of professional support can (loss orientation) versus sources of secondary stress, also be regarded as an interpersonal resource factor, such as dealing with fi nances (restoration orientation). encompassing the more formal level of social support Following this model, adaptive grieving entails both than that provided within the family, friendship, and confrontation and avoidance of the two types of stressor. neighbourhood networks.
Researchers are currently testing variables of the model The way that an individual goes about coping with and using the model as a guideline for designing bereavement is important because, unlike many other intervention programmes.164,165
variables, it can be changed—eg, it may be amenable to
brief interventions.77 In recent decades, researchers have Conclusions
been critical of the generally accepted notion that so-called
We have noted that situational, intrapersonal, inter- grief work (confronting the reality of loss and personal, and coping factors aff ect bereavement outcome. relinquishing the bond to the deceased individual)162 is They do so in complex ways and there could be essential for overcoming bereavement.5 Empirical interactions between factors (eg, between personality and research has shown that people who do not work through circumstances of death) that operate to aff ect outcome. their grief frequently recover as well as, if not better than, Many potential risk factors have been under-researched. those who do so.155,163 Findings of studies on benefi ts of The ways that risk factors relate precisely to the diff erent emotional disclosure or social sharing,5,156 or on negative health outcomes also remain to be seen—eg, why one eff ects of avoidance or repression,59,155 also provided little person can succumb to mental-health disorders while support for the grief-work notion. another might die prematurely after bereavement. By contrast, fi ner-grained examinations of maladaptive processes have provided useful leads. Findings of such Intervention effi
studies suggest the importance of positive and negative Since bereavement increases the risk of negative health cognitions and the regulation of emotion in the grieving outcomes for some individuals, research needs to establish process,52 both of which have been integrated in the dual whether intervention is to be recommended and whether process model of coping with loss.160 This model (fi gure) intervention is actually eff ective. The focus here is on addresses shortcomings of the grief work model and psychological and not medical or pharmacological posits an oscillation process, whereby the bereaved intervention: we restrict the discussion to eff ectiveness individuals would confront and avoid stressors to do studies of psychosocial and psychological counselling and www.thelancet.com Vol 370 December 8, 2007
therapy programmes (to our knowledge, very little research Australia) countries. At the same time, we have noted exists on the eff ectiveness of pharmacological and medical that grief is a normal natural process after bereavement. interventions for bereaved people, but Alexopoulos166 and Most reactions are not complicated and for most Raphael and colleagues88 provide relevant information. bereaved people, family and friends, religious and The Center for the Advancement of Health addresses the community groups, and various societal resources will role of health-care professionals and health systems provide the necessary support. Professional psychological issues11). A few previous reviews have been published.6,11,167–170 intervention is generally neither justifi ed nor eff ective Our own narrative review published in 20016 was based on strict methodological selection criteria (presence of control Much is now known about typical manifestations of groups, non-systematic assignment to the experimental grief and grieving, and there is growing understanding and control condition, an appropriate design with valid about factors that either complicate the course of grief and reliable assessment instruments, correct statistical over time, raise the risk of other mental and physical analyses, etc) and excluded studies that were not primarily disabilities, or both. Progress has also been made in the aimed at bereaved people. Table 3 summarises and updates design and provision of psychological intervention for the conclusions arrived at in 2001 and 2005.
those who need it. Nevertheless, although the quality of Grief interventions can be divided into primary, studies in the various areas reviewed above is better secondary, and tertiary preventive interventions.6 Primary than in previous research, methodological shortcomings preventive interventions are those in which professional still are present in some investigations (eg, selection help is available to all bereaved individuals irrespective of biases, small samples, poor response, and high dropout whether intervention is indicated. Secondary preventive rates). interventions are designed for bereaved individuals who, Furthermore, even though we were able to make through screening or assessment, can be regarded as statements about general occurrences and manifesta-more vulnerable to the risks of bereavement (eg, high tions associated with bereavement, considerable gaps in levels of distress, traumatic circumstances of loss, etc). knowledge remain. For example, some of the most recent Tertiary preventive interventions denote those providing studies of the mortality of bereavement are still of spousal therapy for complicated grief, grief-related depression, or loss: the eff ect of other types of bereavement on mortality post-traumatic disorders, usually evident longer after has received too little research attention. Likewise, we bereavement (since pathological processes usually take need to learn more about codeterminants of the poorer time to develop).
outcomes of bereavement, to understand how the circumstances of bereavement interact with Conclusions
pre-bereavement experience, personal factors, and ways As Parkes,187 the leading expert on bereavement, stated, of coping with grief to cause diffi there is “no evidence that all bereaved people will benefi t scope for improvement in the design of intervention from counselling and research has shown no benefi ts to studies and for strict assessment of their eff ectiveness arise from the routine referral to counselling for no other following evidence-based treatment criteria.
reason than that they have suff ered a bereavement”. Confl ict of interest statement
Primary prevention can, however, be helpful when the We declare that we have no confl ict of interest.
initiative is left with the bereaved individual. Both in Acknowledgments
terms of suff ering and fi nances, this strategy is to be We thank Dora Black, Colin Murray Parkes, and Beverley Raphael for
recommended. This approach needs an accessible their comments on parts of this Review.
infrastructure of grief counselling organisations. References
Interventions for risk groups are an important provision,
Stroebe MS, Hansson RO, Schut H, Stroebe W. Handbook of bereavement research and practice: advances in theory and but improvements in assessment of empirically based intervention. Washington, DC: American Psychological Association, risk factors are essential for better results to be achieved. A reasonably wide variety of treatment modalities for 2 Stroebe MS, Stroebe W, Hansson RO. Handbook of bereavement: Theory, research, and intervention. New York: Cambridge University complicated grief is available and these are generally quite eff ective.6 Systematic comparison of the relative 3 Stroebe MS, Hansson RO, Stroebe W, Schut HAW. Handbook of eff ectiveness of diff erent therapeutic approaches is bereavement research: consequences, coping and care. Washington DC: American Psychological Association, 2001.
needed to understand what works for whom. A fi rst step 4 Stroebe MS, Stroebe W, Schut H. Gender diff erences in adjustment in this direction would be to address closely gender to bereavement: an empirical and theoretical review. Rev Gen Psychol diff erences in the eff ectiveness of intervention.181 2001; 5: 62–83.
Stroebe W, Schut H, Stroebe MS. Grief work, disclosure and counseling: do they help the bereaved? Clin Psychol Rev 2005; Final comments
25: 395–414.
We have recorded negative health issues across various 6 Schut H, Stroebe M, van den Bout J, Terheggen M. The effi mental and physical outcomes and for some diff erent bereavement interventions: Who benefi ts? In: Stroebe MS, Hansson RO, Stroebe W, Schut H, eds. Handbook of bereavement types of bereavement, fi nding quite consistent patterns research: consequences, coping, and care. Washington, DC: in research from various (mostly the USA, Europe, and American Psychological Association, 2001: 705–737.
www.thelancet.com Vol 370 December 8, 2007
Hansson RO, Stroebe, MS Bereavement in late life: development, 35 Parkes CM. Bereavement: Studies of grief in adult life (3rd edn). coping, and adaptation.Washington, DC: American Psychological 36 Murphy SA, Lohan J, Braun T, et al. Parents’ health, health care Holmes TH, Rahe RH. The social readjustment rating scale. utilization, and health behaviors following the violent deaths of J Psychosom Res 1967; 11: 213–18.
their 12-to 28-year-old children: a prospective longitudinal Christ GH, Siegel, K, Christ AE. Adolescent grief “It never really hit analysis. Death Stud 1999; 23: 589–616.
me until it actually happened”. JAMA 2005; 288: 1269–79.
37 Thompson LW, Breckenridge JN, Gallagher D, Peterson JA. 10 Hansson RO, Stroebe MS. Grief, older adulthood. In: Gullotta TP, Eff ects of bereavement on self-perceptions of physical health in Bloom M, eds. The encyclopedia of primary prevention and health elderly widows and widowers. J Gerontol 1984; 39: 309–14.
promotion. Boston: Kluwer, 2003: 515–21.
38 Prigerson H, Silverman GK, Jacobs S, Maciejewski P, Kasl SV, 11 Center for the Advancement of Health. Report on bereavement and Rosenheck R. Traumatic grief, disability and the underutilization grief research. Death Stud 2004; 28: 491–575.
of health services: a preliminary look. Prim Psychiatry 2001; 8:
12 Stroebe MS, Stroebe W. The mortality of bereavement: a review. In: Stroebe MS, Stroebe W, Hansson RO, eds. Handbook of 39 Chen JH, Bierhals AJ, Prigerson HG, Kasl SV, Mazure CM, bereavement: theory, research, and intervention. New York: Jacobs S. Gender diff erences in the eff ects of bereavement-related Cambridge University Press, 1993: 175–95.
psychological distress in health outcomes. Psychol Med 1999; 29:
13 Agerbo E. Midlife suicide risk, partner’s psychiatric illness, spouse and child bereavement by suicide or other modes of death: a gender 40 Bradbeer M, Helme RD, Yong HH, Kendig HL, Gibson SJ. specifi c study. J Epidemiol Community Health 2005; 59: 407–12.
Widowhood and other demographic associations of pain in 14 Bowling A. Mortality after bereavement: an analysis of mortality independent older people. Clin J Pain 2003; 19: 247–54.
rates and associations with mortality 13 years after bereavement. 41 Shahar D, Schultz R, Shahar A, Wing R. The eff ect of widowhood Int J Geriatr Psychiatry 1994; 9: 445–59.
on weight change, dietary intake, and eating behavior in the 15 Christakis N, Allison P. Mortality after the hospitalization of a elderly population. J Aging Health 2001; 13: 186–99.
spouse. N Engl J Med 2006; 354: 719–30.
42 Schulz R, Beach SR, Lind B, et al. Involvement in caregiving and 16 Elwert F, Christakis N. Widowhood and race. Am Sociol Rev 2006; 71:
adjustment to the death of a spouse. JAMA 2001; 285: 3123–29.
43 Neimeyer RA, Hogan NS. Quantitative or qualitative? 17 Erlangsen A, Jeune B, Bille-Brahe U, Vaupel JW. Loss of partner and Measurement issues in the study of grief. In: Stroebe MS, suicide risks among oldest old: a population-based register study. Hansson RO, Stroebe W, Schut H, eds. Handbook of Age Ageing 2004; 33: 378–383.
bereavement research: Consequences, coping, and care. Washington DC: American Psychological Association, 2001: 18 Kposowa A. Marital status and suicide in the National Longitudinal Mortality Study. J Epidemiol Community Health 2000; 54: 254–61.
44 Byrne GJ, Raphael B. The psychological symptoms of conjugal 19 Li G. The interaction eff ect of bereavement and sex on the risk of bereavement in elderly men over the fi rst 13 months. suicide in the elderly: an historical cohort study. Soc Sci Med 1995; Int J Geriatr Psychiatry 1997; 12: 241–51.
40: 825–28.
45 Rosengard C, Folkman S. Suicidal ideation, bereavement, HIV 20 Li J, Precht DH, Mortensen PB, Olsen J. Mortality in parents after serostatus and psychosocial variables in partners of men with AIDS. death of a child in Denmark: a nationwide follow-up study. Lancet AIDS Care 1997; 9: 373–84.
2003; 361: 363–67.
46 Latham AE, Prigerson, H. Suicidality and bereavement: Complicated 21 Lichtenstein P, Gatz M, Berg S. A twin study of mortality after grief as psychiatric disorder presenting greatest risk for suicide. spousal bereavement. Psychol Med 1998; 28: 635–43.
Suicide Life Threat Behav 2004; 34: 350–62.
22 Lillard LA, Waite LJ. Till death do us part—marital disruption and 47 Segal NL, Roy, A. Suicidal attempts and ideation in twins whose mortality. Am J Sociol 1995; 100: 1131–56.
co-twins’ deaths were non-suicides: replication and elaboration. 23 Manor O, Eisenbach Z. Mortality after spousal loss: are there Pers Individ Diff 2001; 31: 445-452.
socio-demographic diff erences? Soc Sci Med 2003; 56: 405–13.
48 Range LM, Knott EC. Twenty suicide assessment instruments: 24 Martikainen P, Valkonen T. Mortality after death of spouse in Evaluation and recommendations. Death Stud 1997; 21: 25–58.
relation to duration of bereavement in Finland. 49 Lund DA, Caserta MS, Dimond MF. The course of spousal J Epidemiol Community Health 1996; 50: 264–68.
bereavement in later life. In: Stroebe MS, Stroebe W, Hansson RO, 25 Martikainen P, Valkonen T. Mortality after the death of a spouse: eds. Handbook of bereavement: Theory, research, and intervention. Rates and causes of death in a large Finnish cohort. Am J Pub Health New York: Cambridge University Press, 1993: 240–54.
1996; 86: 1087–93.
50 van Baarsen B, van Duijn MA, Smit JH, Snijders TA, 26 Martikainen P, Valkonen T. Do education and income buff er the Knipscheer KP. Patterns of adjustment to partner loss in old age: the eff ects of death of spouse on mortality? Epidemiology 1998; 9: 530–34.
widowhood adaptation longitudinal study. Omega 2001–02; 44: 4–36.
27 Mendes de Leon C, Kasl S V, Jacobs S. Widowhood and mortality 51 Hardison HG, Neimeyer RA, Lichstein KL. Insomnia and risk in a community sample of the elderly: a prospective study. complicated grief symptoms in bereaved college students. J Clin Epidemiol 1993; 46: 519–27.
Behav Sleep Med 2005; 3: 99–111.
28 Qin P, Mortensen PB. The impact of parental status on the risk 52 Boelen PA. Complicated grief: Assessment, theory, and treatment. of completed suicide. Arch Gen Psychiatry 2003; 60: 797–802.
29 Schaefer C, Quesenberry CP, Wi S. Mortality following conjugal 53 Ogrodniczuk JS, Piper WE, Joyce AS, et al. Diff erentiating bereavement and the eff ects of a shared environment. symptoms of complicated grief and depression among psychiatric Am J Epidemiol 1995; 141: 1142–52.
outpatients. Can J Psychiatry 2003; 48: 87–93.
30 Smith KR, Zick CD. Risk of mortality following widowhood: Age 54 Prigerson HG, Jacobs SC. Perspectives on care at the close of life. and sex diff erences by mode of death. Soc Biol 1996; 43: 59–71.
Caring for bereaved patients: “all the doctors just suddenly go”. 31 Bradsher JE, Longino CF Jr, Jackson DJ, Zimmerman RS. Health JAMA 2001; 286: 1369–76.
and geographic mobility among the recently widowed. J Gerontol 55 Prigerson HG, Frank E, Kasl SV, et al. Complicated grief and 1992; 47: S261–68.
bereavement-related depression as distinct disorders: preliminary 32 Duberstein PR, Conwell Y, Cox C. Suicide in widowed persons: A empirical validation in elderly bereaved spouses. Am J Psychiatry psychological autopsy comparison of recently and remotely 1995; 152: 22–30.
bereaved older subjects. Am J Geriatr Psychiatry 1998; 6: 328–34.
56 Wijngaards-de Meij L, Stroebe M, Schut H, et al. Couples at risk 33 Kaprio J, Koskenvuo M, Rita H. Mortality after bereavement: a following the death of their child: predictors of grief versus prospective study of 95,647 widowed persons. Am J Public Health depression. J Consult Clin Psychol 2005; 73: 617–23.
1987; 77: 283–87.
57 O’Connor MF, Allen J, Kaszniak AW. Autonomic and emotion 34 Stroebe M, Stroebe W, Abakoumkin G. The broken heart: regulation in bereavement and depression. J Psychosom Res 2002; Suicidal ideation in bereavement. Am J Psychiatry 2005; 162:
52: 183–85.
www.thelancet.com Vol 370 December 8, 2007
58 Boerner K, Wortman CB, Bonanno GA. Resilient or at risk? A 82 Bisconti TL, Bergeman CS, Boker SM. Emotional well-being in 4-year study of older adults who initially showed high or low recently bereaved widows: a dynamical systems approach. distress following conjugal loss. J Gerontol 2005; 60: P67–73.
J Gerontol B Psychol Sci Soc Sci 2004; 59: 158–67.
59 Bonanno GA, Papa A, Lalande K, Zhang N, Noll JG. Grief 83 McCrae RR, Costa PT. Psychological resilience among widowed processing and deliberate grief avoidance: a prospective men and women: a 10-year follow-up of a national sample. In: comparison of bereaved spouses and parents in the United States Stroebe MS, Stroebe W, Hansson RO, eds. Handbook of and the People’s Republic of China. J Consult Clin Psychol 2005; 73:
bereavement: Theory, research, and intervention. New York: Cambridge University Press, 1993: 196–207.
60 Rosenblatt PC, Wallace BR. African American grief. New York: 84 Archer J. The nature of grief: The evolution and psychology of reactions to grief. London: Routledge,1999.
61 Rubin SS, Yasien-Esmael H. Loss and bereavement among Israeli’s 85 American Psychiatric Association. Diagnostic and statistical Muslims: acceptance of God’s will, grief, and the relationship to the manual of disorders (4th edn). Washington DC: American deceased. Omega 2004; 49: 149–62.
62 Wikan U. Bereavement and loss in two Muslin communities: Egypt 86 Schaefer JA, Moos RH. Bereavement experiences and personal and Bali. Soc Sci Med 1988; 27: 451–60.
growth. In: Stroebe MS, Hansson RO, Stroebe W, Schut H, eds. 63 Kleinman A, Good B. Culture and depression: Studies in the Handbook of bereavement research: consequences, coping, and anthropology and cross-cultural psychiatry of aff ect and disorder. care. Washington DC: American Psychological Association, 2001: Berkeley: University of California Press, 1985.
64 Simon G, VonKorff M, Piccinelli M, Fullerton C, Ormel J. An 87 Simonton D. Great psychologists and their times. Washington, DC: international study of the relation between somatic symptoms and American Psychological Association, 1988.
depression. N Engl J Med 1999; 341: 1329–34.
88 Raphael B, Minkov C, Dobson M. Psychotherapeutic and 65 Parkes CM, Laungani P, Young, B. Death and bereavement across pharmacological intervention for bereaved persons. In: Stroebe MS, Hansson RO, Stroebe W, Schut H, eds. Handbook of bereavement 66 Fry PS. Grandparents’ reactions to the death of a grandchild: an research: Consequences, coping, and care. Washington, DC: exploratory factor analytic study. Omega 1997; 35: 119–40.
American Psychological Association, 2001: 587–612.
67 Lin KK, Sandler IN, Ayers TS, Wolchik SA, Luecken LJ. Resilience 89 Kaltman S, Bonanno GA. Trauma and bereavement: examining the in parentally bereaved children and adolescents seeking preventive impact of sudden and violent deaths. J Anxiety Disord 2003; services. J Clin Child Adolesc Psychol 2004; 33: 673–83.
17: 131–47.
68 Kirwin KM, Hamrin V. Decreasing the risk of complicated 90 Murphy SA, Johnson LC, Chung I, Beaton RD. The prevalence of bereavement and future psychiatric disorders in children. PTSD following the violent death of a child and predictors of change J Child Adolesc Psychiatr Nurs 2005; 18: 62–78.
5 years later. J Traumatic Stress 2003; 16: 17–25.
69 Rotherham-Borus MJ, Weiss R, Alber S, Lester P. Adolescent 91 Surtees PG. In the shadow of adversity: The evolution and resolution adjustment before and after HIV-related parental death. of anxiety and depressive disorder. Br J Psychiatry 1995; 166: 583–94.
J Consult Clin Psychol 2005; 73: 221–28.
92 Li J, Laursen TM, Precht DH, Olsen J, Mortensen PB. 70 Scharlach AE. Factors associated with fi lial grief following the death Hospitalization for mental illness among parents after the death of a of an elderly parent. Am J Orthopsychiatry 1991; 61: 307–13.
child. N Engl J Med 2005; 352: 1190–96.
71 Murphy SA, Das Gupta A, Cain KC, et al. Changes in parents’ 93 Prigerson H, Jacobs, S. Traumatic grief as a distinct disorder: a mental distress after the violent death of an adolescent or young rationale, consensus criteria, and a preliminary empirical test. In: adult child: a longitudinal prospective analysis. Death Stud 1999; Stroebe MS, Hansson RO, Stroebe W, Schut H, eds. Handbook of 23:129–59.
bereavement research: consequences, coping, and care. Washington, DC: American Psychological Association, 2001: 613–45.
72 Murphy SA, Johnson LC, Wu L, Fan JJ, Lohan J. Bereaved parents’ outcomes 4 to 60 months after their children’s deaths by accident, 94 Jacobs S. Pathologic grief: Maladaptation to loss. Washington, DC: suicide, or homicide: a comparative study demonstrating diff erences. Death Stud 2003; 27: 39–61.
95 Parkes CM, Weiss RS. Recovery from bereavement. New York: 73 Rubin SS, Malkinson R. Parental response to child loss across the life cycle: clinical and research perspectives. In: Stroebe MS, 96 Prigerson H, Maciejeski, P. A call for sound empirical testing and Hansson RO, Stroebe W, Schut H, eds. Handbook of bereavement evaluation of criteria for complicated grief proposed for DSM-V. research: consequences, coping, and care. Washington DC: Omega 2005; 52: 9–19.
American Psychological Association, 2001: 219–40.
97 Averill JR. Grief: its nature and signifi cance. Psychol Bull 1968; 74 Barr P. Guilt- and shame-proneness and the grief of perinatal 70: 721–48.
bereavement. Psychol Psychother 2004; 77: 493–510.
98 Middleton W, Burnett P, Raphael B, Martinek N. The bereavement 75 Vance JC, Boyle FM, Najman JM, Thearle MJ. Couple distress after response: a cluster analysis. Br J Psychiatry 1996; 169: 167–71.
sudden infant or perinatal death: a 30-month follow-up. 99 Horowitz MJ, Siegel B, Holen A, Bonanno GA, Milbrath C, J Paediatr Child Health 2002; 38: 368–72.
Stinson CH. Diagnostic criteria for complicated grief disorder. 76 Sklar FHS. Close friends as survivors: Bereavement patterns in a Am J Psychiatry 1997; 154: 904–10.
“hidden” population. Omega 1991; 21: 103–12.
100 Parkes CM. Complicated grief: a symposium. Omega 2005; 77 Folkman S. Revised coping theory and the process of bereavement. 52: whole issue.
In: Stroebe MS Hansson RO, Stroebe W, Schut H, eds. Handbook 101 Dyregrov K, Nordanger D, Dyregrov A. Predictors of psychosocial of bereavement research: consequences, coping, and care. distress after suicide, SIDS and accidents. Death Stud 2003; 27:
Washington DC: American Psychological Association, 2001: 563–84.
78 Sikkema KJ, Hansen NB, Kochman A, Tate DC, Difranceisco W. 102 Averill J. The functions of grief. In: Izard C, ed. Emotions in Outcomes from a randomized controlled trial of a group personality and psychopathology. New York, 1979: 339–68.
intervention for HIV positive men and women coping with 103 Aartsen MJ, van Tilburg T, Smits CH, Comijs HC, AIDS-related loss and bereavement. Death Stud 2004; 28: 187–209.
Knipscheer KC. Does widowhood aff ect memory performance of 79 Sikkema KJ, Hansen NB, Meade CS, Kochman A, Lee RS. older people? Psychol Med 2004; 34: 1–10.
Improvements in health-related quality of life following a group 104 Rosenbloom CA, Whittington FJ. The eff ects of bereavement on intervention for coping with AIDS-bereavement among eating behaviors and nutrient intakes in elderly widowed persons. HIV-infected men and women. Qual Life Res 2005; 14: 991–1005.
J Gerontol; 48: S223–29.
80 Bowlby J. Attachment and loss, vol 3: Loss: sadness and 105 Carr D, Nesse RM, Wortman C. Late life widowhood in the United depression. London: Hogarth Press, 1980.
States. New York: Springer Publishing Co, 2005.
81 Worden JW. Grief counseling and grief therapy: A handbook for 106 Utz RL, Carr D, Nesse R, Wortman CB. The eff ect of widowhood the mental health practitioner, 3rd Edn. New York: Springer on older adults’ social participation: An evaluation of activity, disengagement, and continuity theories. Gerontologist; 42: 522–33.
www.thelancet.com Vol 370 December 8, 2007
107 Gerra G, Monti D, Panerai AE, et al. Long-term 129 Bernard LL, Guarnaccia CA. Two models of caregiver strain and immune-endocrine eff ects of bereavement: Relationships with bereavement adjustment: a comparison of husband and daughter anxiety levels and mood. Psychiatry Res 2003; 121: 145–58.
caregivers of breast cancer hospice patients. Gerontologist 2003; 108 Gündel H, O’Connor M-F, Littrell L, Fort C, Lane R. Functional 43: 808–16.
neuroanatomy of grief: an MRI study. Am J Psychiatry 2003; 160:
130 Seltzer MM, Lee LW. The dynamics of caregiving: transitions during a three-year prospective study. Gerontologist 2000; 40: 165–78.
109 O’Connor M, Allen J, Kaszniak A. Autonomic and emotion 131 Cleiren MH. Bereavement and adaptation: a comparative study of regulation in bereavement and depression. J Psychosom Res 2002; the aftermath of death. Washington, DC: Hemisphere, 1993.
52: 183–85.
132 Nolen-Hoeksema SL J. Coping with loss. Mahwah, NJ: Mahwah, 110 Stroebe M, Folkman S, Hansson RO, Schut H. The prediction of bereavement outcome: development of an integrative risk factor 133 Carr D, House JS, Kessler RC, Nesse RM, Sonnega J, Wortman C. framework. Soc Sci Med 2006; 63: 2446–51.
Marital quality and psychological adjustment to widowhood 111 Stroebe W, Schut H. Risk factors in bereavement outcome: a among older adults: a longitudinal analysis. methodological and empirical review. In: Stroebe MS, Stroebe W, J Gerontol B Psychol Sci Soc Sci 2000; 55: S197–207.
Hansson RO, Schut H, eds. Handbook of bereavement research: 134 Carr D. Black/White diff erences in psychological adjustment to consequences, coping, and care. Washington, DC: American spousal loss among older adults. Res Aging 2004; 26: 591–622.
Psychological Association, 2001: 349–71.
135 Prigerson H, Maciejewski P, Rosenheck R. Preliminary 112 Carr D, House JS, Wortman C, Nesse R, Kessler RC. Psychological explorations of the harmful interactive eff ects of widowhood and adjustment to sudden and anticipated spousal loss among older marital harmony on health, health service use, and health care widowed persons. J Gerontol B Psychol Sci Soc Sci 2001; 56:
costs. Gerontologist 2000; 40: 349–57.
136 Murdoch ME, Guarnaccia CA, Hayslip B Jr, McKibbin CL. The 113 Raphael B, Martinek N. Assessing traumatic bereavements and contribution of small life events to the psychological distress of PTSD. In: Wilson JP, Keane TM, eds. Assessing psychological married and widowed older women. J Women Aging 1998; 10:
trauma and PTSD. New York: Guilford, 1997: 373–95.
114 Barry LC, Kasl SV, Prigerson HG. Psychiatric disorders among 137 Moskowitz JT, Folkman S, Acree M. Do positive psychological bereaved persons: the role of perceived circumstances of death states shed light on recovery from bereavement? Findings from a and preparedness for death. Am J Geriatr Psychiatry 2002; 10:
3-year longitudinal study. Death Stud 2003; 27: 471–500.
138 Haine RA, Ayers TS, Sandler IN, Wolchik SA, Weyer JL. Locus of 115 Ong AD, Bergeman, CS, Bisconti, TL. Unique eff ects of daily control and self-esteem as stress-moderators or stress-mediators perceived control on anxiety symptomatology during conjugal in parentally bereaved children. Death Stud 2003; 27: 619–40.
bereavement. Pers Individ Diff 2005; 38: 1057–67.
139 Stroebe M, Schut H, Stroebe W. Attachment in coping with 116 Harwood D, Hawton K, Hope T, Jacoby R. The grief experiences bereavement: a theoretical integration. Rev Gen Psychol 2005; 9:
and needs of bereaved relatives and friends of older people dying through suicide: a descriptive and case-control study. J Aff ect Disord 140 Parkes CM. Love and loss: the roots of grief and its complications. 2002; 72: 185–94.
117 Cerel J, Fristad MA, Weller EB, Weller RA. Suicide-bereaved 141 Luecken LJ. Attachment and loss experiences during childhood are children and adolescents: a controlled longitudinal examination. associated with adult hostility, depression, and social support. J Am Acad Child Adolesc Psychiatry 1999; 38: 672–79.
J Psychosom Res 2000; 49: 85–91.
118 Prigerson HG, Cherlin E, Chen JH, Kasl SV, Hurzeler R, Bradley 142 Luecken LJ, Appelhaus. Early parental loss and salivary cortisol in EH. The Stressful Caregiving Adult Reactions to Experiences of young adulthood: The moderating role of family environment. Dying (SCARED) scale: a measure for assessing caregiver exposure Dev Psychopathol 2006; 18: 295–308.
to distress in terminal care. Am J Geriatr Psychiatry 2003; 11: 309–19.
143 Nicolson NA. Childhood parental loss and cortisol levels in adult 119 Carr D. A ‘good death’ for whom? Quality of spouse’s death and men. Psychoneuroendocrinol 2004; 29: 1012–18.
psychological distress among older persons. J Health Soc Behav 144 Tsuchiya KJ, Agerbo E, Mortensen PB. Parental death and bipolar 2003; 44: 215–32.
disorder: A robust association was found in early maternal suicide. 120 Fristad MA, Cerel J, Goldman M, Weller EB, Weller RA. The role of J Aff ect Disord 2005; 86: 151–59.
ritual in children’s bereavement. Omega 2001; 42: 321–39.
145 Mikulincer M, Shaver P. An attachment perspective on 121 Ringdal GI, Jordhoy MS, Ringdal K, Kaasa S. Factors aff ecting grief bereavement. In Stroebe M, Hansson RO, Schut H, Stroebe W, eds.
reactions in close family members to individuals who have died of Handbook of bereavement research and practice: advances in cancer. J Pain Symptom Manage 2001; 22: 1016–26.
theory and intervention. Washington, DC: American Psychological 122 Christakis NA, Iwashyna TJ. The health impact of health care on families: a matched cohort study of hospice use by decedents and 146 Mack KY. The eff ects of early parental death on sibling relationships mortality outcomes in surviving, widowed spouses. Soc Sci Med in later life. Omega 2004; 49: 131–48.
2003; 57: 465–75.
147 Benore ER, Park CL. Death-specifi c religious beliefs and 123 Goodenough B, Drew D, Higgins S, Trethewie S. Bereavement bereavement: belief in an afterlife and continued attachment. outcomes for parents who lose a child to cancer: are place of Int J Psychol Relig 2004; 14: 1–22.
death and sex of parent associated with diff erences in 148 Stroebe M. The role of religion in bereavement: courage of psychological functioning? Psychooncology 2004; 13: 779–91.
convictions or scientifi c scrutiny. Int J Psychol Relig 2004; 14: 23–36.
124 Aneshensel CS, Botticello AL, Yamamoto-Mitani N. When 149 Brown SL, Nesse RM, House JS, Utz RL. Religion and emotional caregiving ends: the course of depressive symptoms after compensation: results from a prospective study of widowhood. bereavement. J Health Soc Behav 2004; 45: 422–40.
Pers Soc Psychol Bull 2004; 30: 1165–74.
125 Ferrario SR, Cardillo V, Vicario F, Balzarini E, Zotti AM. 150 van Grootheest DS, Beekman AT, Broese van Groenou MI, Deeg DJ. Advanced cancer at home: caregiving and bereavement. Sex diff erences in depression after widowhood. Do men suff er more? Palliat Med 2004; 18: 129–36.
Soc Psychiatry Psychiatr Epidemiol 1999; 34: 391–98.
126 Ringdal GI, Ringdal K, Jordhoy MS, Ahlner-Elmqvist M, 151 Lee GR, DeMaris A, Bavin S, Sullivan R. Gender diff erences in the Jannert M, Kassa S. Health-related quality of life (HRQOL) in depressive eff ect of widowhood in later life. J Gerontol 2001; 56B:
family members of cancer victims: results from a longitudinal intervention study in Norway and Sweden. Palliat Med 2004; 18:
108–20.
152 Kreicbergs U, Valdimarsdóttir U, Onelöv E, Henter J, Steineck G. Anxiety and depression in parents 4-9 years after the loss of a child 127 Boerner K, Schulz R, Horowitz A. Positive aspects of caregiving owing to a malignancy: a population-based follow-up. Psychol Med and adaptation to bereavement. Psychol Aging 2004; 19: 668–75.
2004; 34: 1431–41.
128 Schulz R, Mendelsohn AB, Haley W, et al. End-of-life care and the 153 Perkins HW, Harris LB. Familial bereavement and health in adult life eff ects of bereavement on family caregivers of persons with course perspective. J Marriage Fam 1990; 52: 233–41.
dementia. N Engl J Med 2003; 349: 1936–42.
www.thelancet.com Vol 370 December 8, 2007
154 Williams DR, Takeuchi DT, Adair RK. Marital status and psychiatric 172 Morrison Tonkins SA, Lambert MJ. A treatment outcome study of disorders among blacks and whites. J Health Soc Behav 1992; 33:
bereaved groups for children. Child Adolesc Soc Work J 1996; 13: 3–21.
173 Goodkin K, Blaney NT, Feaster DJ, Baldewicz T, Burkhalter JE, 155 Bonanno GA. Grief and emotion: a social-functional perspective. In: Leeds B. A randomized controlled clinical trial of a bereavement Stroebe MS, Hansson RO, Stroebe W, Schut H, eds. Handbook of support group intervention in human immunodefi ciency virus type bereavement research: consequences, coping, and care. Washington 1-seropositive and -seronegative homosexual men. DC: American Psychological Association, 2001: 493–515.
Arch Gen Psychiatry 1999; 56: 52–59.
156 Pennebaker J, Zech E, Rimé, B. Disclosing and sharing emotion: 174 Sandler IN, Ayers TS, Wolchik SA, et al. The family bereavement psychological, social, and health consequences. In: Stroebe MS, cacy evaluation of a theory-based prevention program for Hansson RO, Stroebe W, Schut H, ed. Handbook of bereavement parentally bereaved children and adolescents. J Consult Clin Psychol research: Consequences, coping, and care. Washington, DC: 2003; 71: 587–600.
American Psychological Association, 2001: 517–43.
175 Vachon ML, Lyall WA, Rogers J, Freedman-Letofsky K, Freeman SJ. A 157 Nolen-Hoeksema S. Ruminative coping and adjustment to controlled study of self-help intervention for widows. Am J Psychiatry bereavement. In: Stroebe MS, Hansson RO, Stroebe W, Schut H, 1980; 137: 1380–84.
eds. Handbook of bereavement research: consequences, coping, and 176 Murray JA, Terry DJ, Vance JC, Battistutta D, Connolly Y. Eff ects of a care. Washington, DC: American Psychological Association, 2001: program of intervention on parental distress following infant death. Death Stud 2000; 24: 275–305.
158 Bower JE, Kemeny, ME, Taylor SE, Fahey JL. Cognitive processing, 177 Pfeff er CR, Jiang H, Kakuma T, Hwang J, Metsch M. Group discovery of meaning, CD4 decline, and AIDS-related mortality intervention for children bereaved by the suicide of a relative. among bereaved HIV-seropositive men. J Consult Clin Psychol 1998; J Am Acad Child Adolesc Psychiatry 2002; 41: 505–13.
66: 979–86.
178 Kissane DW, McKenzie M, Bloch S, Moskowitz C, McKenzie DP, 159 Davis C, Nolen-Hoeksema S, Larson J. Making sense of loss and O’Neill I. Family focused grief therapy: a randomized controlled trial benefi ting from the experience: two construals of meaning. in palliative care and bereavement. Am J Psychiatry 2006; 163: 1208–18.
J Pers Soc Psychol 1998; 75: 561–74.
179 Kissane DW, McKenzie M, McKenzie DP, Forbes A, O’Neill I, Bloch S. 160 Stroebe M, Schut H. The dual process model of coping with Psychosocial morbidity associated with patterns of family functioning bereavement: rationale and description. Death Stud 1999; 23: 197–224.
in palliative care: baseline data from the Family Focused Grief Therapy 161 Zettel LA, Rook KS. Substitution and compensation in the social controlled trial. Palliat Med 2003; 17: 527–37.
networks of older widowed women. Psychol Aging 2004; 19: 433–43.
180 Kempson DA. Eff ects of intentional touch on complicated grief of 162 Freud S. Mourning and melancholia. In: Strachey J, ed. Standard bereaved mothers. Omega 2001; 42: 341–53.
edition of the complete works of Sigmund Freud. London: Hogarth, 181 Schut HA, Stroebe MS, van den Bout J, de Keijser J. Intervention for the bereaved: gender diff erences in the effi 163 Wortman C, Silver R. The myths of coping with loss revisited. In: programmes. Br J Clin Psychol 1997; 36: 63–72.
Stroebe MS, Hansson RO, Stroebe W, Schut H, ed. Handbook of 182 Murphy SA, Johnson C, Cain KC, Das Gupta A, Dimond M, Lohan J. bereavement research: consequences, coping, and care. Washington, Broad-spectrum group treatment for parents bereaved by the violent DC: American Psychological Association, 2001: 405–29.
deaths of their 12- to 28-year-old children: A randomized controlled 164 Lund DA, Caserta MS, deVries B, Wright S. Restoration after trial. Death Stud 1998; 22: 209–35.
bereavement. Generations review: Br Soc Gerontol 2004; 14: 9–15.
183 Wagner B, Knaevelsrud C, Maercker A. Internet-based 165 Shear K, Frank E, Houck PR, Reynolds CF 3rd. Treatment of cognitive-behavioral therapy (INTERAPY) for complicated grief: A complicated grief: a randomized controlled trial. JAMA 2005; 293:
randomized controlled trial. Death Stud 2006; 30: 429–53.
184 Reynolds CF, Miller MD, Pasternak RE, et al. Treatment of 166 Alexopoulos GS. Depression in the elderly. Lancet 2005; 365: 1961–70.
bereavement-related major depressive episodes in later life: A 167 Kato PM, Mann T. A synthesis of psychological interventions for the controlled study of acute and continuation treatment with bereaved. Clin Psychol Rev 1999; 19: 275–96.
nortriptyline and interpersonal psychotherapy. Am J Psychiatry 1999; 168 Litterer Allumbaugh D, Hoyt WT. Eff ectiveness of grief therapy: a 156: 202–08.
meta-analysis. J Counsel Psychol 1999; 46: 370–80.
185 Ogrodniczuk JS, Piper WE, Joyce AS. Diff erences in men’s and 169 Jordan JR, Neimeyer RA. Does grief counseling work? Death Stud women’s responses to short-term group psychotherapy. Psychother Res 2003; 27: 765–86.
2004; 14: 231–43.
170 Schut H, Stroebe M. Interventions to enhance adaptation to 186 Piper WE, McCallum M, Joyce AS, Rosie JS, Ogrodniczuk JS. Patient bereavement. J Palliat Med 2005; 8: S140–47.
personality and time-limited group psychotherapy for complicated
grief. Int J Group Psychother 2001; 51: 525–52.
171 Black D, Urbanowicz MA. Family intervention with bereaved children. J Child Psychol Psychiatry 1987; 28: 467–76.
187 Parkes CM. Editorial comments. Bereavement Care 1998; 17: 18.
www.thelancet.com Vol 370 December 8, 2007

Source: http://www.universidaddelasalud.es/paliativos/pdf/Health%20outcomes%20of%20bereavement.pdf

Hutchison china meditech ("chi-med") (aim: hcm)

China Biotech In Review: Chindex Buys Israeli Laser Company For $240 Million Shanghai Fosun Pharma (SH: 600196; HK: 02196), Chindex (NSDQ: CHDX) and a private equity partner willspend up to $240 million to buy 95.6% of an Israeli medical device company, Alma Lasers (see story). Alma,which had revenues of about $100 million last year, makes lasers and other products, primarily for aestheticp

lauftreffreisen.de

Wolfgang Hofmann Coordinator Jean-Paul-Str. 14 D 40470 DüsseldorfFon: +49 (0)211 612087 Fax: +49 (0)211 612089Mobile: +49 (0)173 2569881 Mail: hofmann-wolfgang@gmx.de SAHARAULTRAMARATHON2007 WESTSAHARA The Race in brief UltraMarathon 160,9344 kilometres non stop race from Bir Lehlu to Tifariti. The start will be. 21 kilometer in front of Bir Lehlu Only desert region on a track road

Copyright © 2010-2014 PDF pharmacy articles