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Read this Patient Information before you start using ZECUITY and each time
you get a refill. There may be new information. This information does not take the place of talking with your healthcare provider about your medical
What is the most important information I should know about
ZECUITY can cause serious side effects, including:
Heart attack and other heart problems. Heart problems may lead to
Stop using ZECUITY and get emergency medical help right away if
you have any of the following symptoms of a heart attack:
discomfort in the center of your chest that lasts for more than a few
minutes, or that goes away and comes back
chest pain or chest discomfort that feels like an uncomfortable heavy
pain or discomfort in your arms, back, neck, jaw, or stomach shortness of breath with or without chest discomfort breaking out in a cold sweat nausea or vomiting feeling lightheaded
ZECUITY is not for people with risk factors for heart disease unless a heart exam is done and shows no problem. You have a higher risk for heart disease if you: have high blood pressure have high cholesterol levels smoke are overweight have diabetes have a family history of heart disease
are a female who has gone through menopause are a male over age 40
What is ZECUITY?
ZECUITY is a prescription medicine used for the acute treatment of migraine
headaches with or without aura in adults. ZECUITY comes in an
iontophoretic transdermal system (TDS) that uses a mild electrical current to deliver the medicine sumatriptan through your skin.
ZECUITY is used for people who have been told by a healthcare provider that they have migraine headaches. ZECUITY is not used to prevent or decrease the number of migraine headaches you have. It is not known if ZECUITY is safe and effective in children under 18 years of age.
Who should not use ZECUITY?
Do not use ZECUITY if you have:
heart problems or a history of heart problems
had a stroke, transient ischemic attacks (TIAs), or problems with your
narrowing of blood vessels to your legs, arms, stomach, or kidney
uncontrolled high blood pressure hemiplegic migraines or basilar migraines. If you are not sure if you have
these types of migraines, ask your healthcare provider
taken any of the following medicines in the last 24 hours:
o ergotamines (CAFERGOT®, ERGOMAR®, MIGERGOT®)
o dihydroergotamine (D.H.E. 45®, MIGRANAL®)
Ask your healthcare provider if you are not sure if your medicine is listed above.
severe liver problems an allergy to sumatriptan, the medicine in ZECUITY, or any of the
components in ZECUITY TDS. See the end of this leaflet for a complete list of ingredients in ZECUITY.
What should I tell my healthcare provider before using ZECUITY?
Before you use ZECUITY, tell your healthcare provider about all of your medical conditions, including if you: • have high blood pressure
have high cholesterol have diabetes smoke are overweight are a female who has gone through menopause have heart problems or family history of heart problems or stroke have liver problems have had epilepsy or seizures are not using effective birth control have or have had any side effects caused by the use of electrical devices.
Talk to your healthcare provider if you are not sure if you have a medical
electronic device or sensitivities to electrical devices.
are pregnant or plan to become pregnant. It is not known if ZECUITY will
are breastfeeding or plan to breastfeed. It is not known if the medicine in
ZECUITY passes into your breast milk. You and your healthcare provider should decide if you will use ZECUITY or breastfeed. You should not do both.
Tell your healthcare provider about all the medicines you take,
including prescription and nonprescription medicines, vitamins, and herbal
Using ZECUITY with certain other medicines can affect each other, causing serious side effects.
Especially tell your healthcare provider if
you take anti-
depressant medicines called:
selective serotonin reuptake inhibitors (SSRIs)
serotonin norepinephrine reuptake inhibitors (SNRIs)
monoamine oxidase inhibitors (MAOIs)
Ask your healthcare provider or pharmacist for a list of these medicines if
you are not sure. Know the medicines you take. Keep a list of them to show your healthcare
provider or pharmacist when you get a new medicine. How should I use ZECUITY?
Read the Instructions for Use in the package that comes with your
ZECUITY TDS for information about the right way to use ZECUITY
Certain people should apply their first dose of ZECUITY in their healthcare
provider’s office or in another medical setting. Ask your healthcare
provider if you should use your first dose in a medical setting.
ZECUITY is for use on the skin only.
Use ZECUITY exactly as your healthcare provider tells you to.
Apply 1 ZECUITY to your upper arm or thigh.
apply ZECUITY to other areas of your body. Talk to your
healthcare provider if you are not sure where to apply ZECUITY.
If your headache comes back or you only get some relief from your
headache, you may apply a second ZECUITY to your other arm or thigh,
no sooner than 2 hours after the activation of the previously applied ZECUITY.
Do not apply more than 2 ZECUITY in 24 hours. • If you use too much ZECUITY, call your healthcare provider or go to the
nearest hospital emergency room right away.
It is not known if using more than 4 ZECUITY in 1 month is safe.
What should I avoid while using ZECUITY?
• Do not bathe, shower, or swim while wearing ZECUITY.
• ZECUITY can cause dizziness, weakness, or drowsiness. If you have these
symptoms, do not drive a car, use machinery, or do anything where you
• You should remove ZECUITY before you have a Magnetic Resonance
What are the possible side effects of ZECUITY?
See “What is the most important information I should know about
ZECUITY?” ZECUITY may cause serious side effects including:
injury during a Magnetic Resonance Imaging (MRI).
TDS contains metal parts and must be removed before an MRI.
allergic contact dermatitis (ACD).
Some people have had a serious
skin reaction called allergic contact dermatitis (ACD) where ZECUITY is applied. Symptoms of ACD include:
o itching, redness, or irritation of skin
o blisters that ooze, drain, or crust over
You should stop using ZECUITY and call your healthcare provider if you
have any of the symptoms of ACD. If you have or have had ACD while using ZECUITY and need to take sumatriptan by mouth or injection, your
first dose of sumatriptan should be given in your healthcare provider’s office or in another medical setting.
changes in color or sensation in your fingers and toes (Raynaud’s
stomach and intestinal problems (gastrointestinal and colonic
Symptoms of gastrointestinal and colonic ischemic
problems with blood circulation to your legs and feet (peripheral
Symptoms of peripheral vascular ischemia include:
o cramping and pain in your legs or hips
o feeling of heaviness or tightness in your leg muscles
o burning or aching pain in your feet or toes while resting
o numbness, tingling, or weakness in your legs
o cold feeling or color changes in 1 or both legs or feet
medication overuse headaches.
Some people who use too many
ZECUITY may have worse headaches (medication overuse headache). If your headaches get worse, your healthcare provider may decide to stop
Serotonin syndrome is a rare but serious problem
that can happen in people using ZECUITY, especially if ZECUITY is used with anti-depressant medicines called SSRIs or SNRIs.
Ask your healthcare provider or pharmacist for a list of these medicines if you are not sure. Call your healthcare provider right away if you have any of the following symptoms of serotonin syndrome:
o mental changes such as seeing things that are not there
increases in blood pressure.
You should not use ZECUITY if you have
serious allergic reactions.
Get medical help right away if you have any
of these symptoms of a serious allergic reaction:
o swelling of your face, lips, mouth, or tongue
o fast heartbeat or pounding in your chest (tachycardia)
Seizures have happened in people taking sumatriptan who
have never had seizures before. Talk with your healthcare provider about
your chance of having seizures while you take ZECUITY.
The most common side effects of ZECUITY include
itching, warmth, discomfort or a change in the skin color at the application site of ZECUITY. Most people have some skin redness after removal of ZECUITY. This redness will usually go away in 24 hours. Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of ZECUITY. For more information, ask your healthcare provider or pharmacist. Call your healthcare provider for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
How should I store ZECUITY?
• Store ZECUITY at room temperature between 68°F to 77°F (20°C to
• Do not store ZECUITY in the refrigerator or freezer.
Keep ZECUITY and all medicines out of the reach of children.
General information about the safe and effective use of ZECUITY
Medicines are sometimes prescribed for purposes other than those listed in a
Patient Information leaflet. Do not use ZECUITY for a condition for which it
was not prescribed. Do not give ZECUITY to other people, even if they have the same symptoms that you have. It may harm them. This Patient Information leaflet summarizes the most important information about ZECUITY. If you would like more information, talk to your healthcare
provider. You can ask your healthcare provider or pharmacist for information about ZECUITY that is written for healthcare professionals. For more information, go to www.ZECUITY.com or call 1-855-ZECUITY.
What are the ingredients in ZECUITY?
sumatriptan succinate Inactive ingredients:
• Sumatriptan Reservoir Card and pad:
purified water, basic butylated
methacrylate copolymer (polyamine), lauric acid, adipic acid, methylparaben, and non-woven viscose pad.
• Salt Reservoir Card and pad:
purified water, hydroxypropylcellulose,
sodium chloride, methylparaben, and non-woven viscose pad.
• Iontophoretic device:
medical grade adhesive fabric, foam and plastic
dome containing an activation button, coin cell lithium batteries, and electronics.
This Patient Information has been approved by the U.S. Food and Drug Administration.
Ref: HSD/F6 Issue No: 7 Date of Issue: 18th November, 2005 UNIVERSAL SEALANTS (UK) LIMITED Kingston House, 3 Walton Road, Pattinson North, Telephone No: 0191 416 8360 Fax No: 0191 415 5966 1. Product Identification Trade Name: Description: 2. Composition / Information on Ingredients Ingredient CAS Number Conc. (w/w) Classification R. Phrases 3. Hazard Iden
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