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DAVID ROSENTHAL, D.O.
CURRICULUM VITAE

EDUCATION:

Elmezzi Graduate School of Molecular Medicine, North Shore-Long Island
Jewish Health System, Manhasset, NY
PhD Candidate in Molecular Medicine. Thesis advisor: Vincent R. Bonagura
Long Island Jewish Medical Center, The Long Island Campus for Yeshiva
University, Albert Einstein College of Medicine, New Hyde Park, NY
Graduated June 2006, AOA/ACGME accredited Allergy/Immunology Fellowship
Seton Hall University, School of Graduate Medical Education
St. Michael’s Medical Center, Newark, NJ
Graduated Jun 2003, AOA/ACGME dually accredited Internal Medicine Residency
University of New England, College of Osteopathic Medicine,
St. Michael’s Medical Center, Newark, NJ
Graduated Jun 2003, AOA/ACGME dually accredited Internal Medicine Residency
University of New England, College of Osteopathic Medicine,
St. Michael’s Medical Center, Newark, NJ
Graduated June 2001, American Osteopathic Association (AOA) Internship
Kansas City University of Medicine and Biosciences College of Osteopathic
Medicine (KCUMB-COM), Kansas City, MO
Previously named: University of Health Sciences-College of Osteopathic Medicine
Graduated May 2000, Doctor of Osteopathic Medicine (D.O.)
Brandeis University, Waltham, MA
Graduated Cum Laude with a B.A. in Biology; Dean's List Minor in Near Eastern and Judaic Studies; Completed Pre-Medical Program Clinical Immunology Society, 2010 CIS / Talecris Fellowship Awardee
“Characterization of Deficiency in the Immune Response to Capsular Polysaccharide
Antigens” Principle Investigator; mentored by Vincent R. Bonagura, M.D., $30,000.

North Shore–Long Island Jewish Research Institute, Research Fellowship Award,
Peripheral Regulation of Disease Specific Rheumatoid Factors”, Principle
Investigator, mentored by Vincent R. Bonagura, M.D., $35,000.

AWARDS/HONORS:
North Shore-Long Island Jewish Health System, 2008 Annual Academic
Competition,
Basic Science, First Prize
ST*AR Award, American Academy of Allergy Asthma Immunology
NYSOMS Eastern Regional Resident Research Competition, First Place Award
St. Michael’s Medical Center, Teaching Resident of the Year
Seton Hall University, Research Colloquium, First Place Clinical Investigation
Seton Hall University, Research Colloquium, Honorable Mention
American Academy of Allergy, Asthma, and Immunology, National Resident
Education Program Attendee, one of 40 selected Residents nationwide
NEOMEN OPTI Research Colloquium, First Place, Clinical Investigation
St. Michael’s Medical Center, Dr. Ho Memorial Award for Humanism in Medicine
Brandeis University, Leadership Prize, outstanding campus leadership
Brandeis University, Hyman Rosen Prize, academic excellence & outstanding
leadership in Jewish campus activities.
Brandeis University, Merit Scholarship
Boy Scouts of America, Eagle Scout Award

CLINICAL EXPERIENCE:

North Shore-LIJ Health System, Div. of Allergy/ Immunology, New Hyde Park, NY
Attending Physician, teaching Fellows and House Staff, budget oversight, coordination
and participation in clinical trials and translational research, clinical care for patients with immunodeficiency, including HIV. Experienced in HIV Ryan White Title I and IV funded grants, AIRS software, quality improvement programs and team leading. Laboratory studies as described below. (see Graduate student below)
ACADEMIC EXPERIENCE:

Albert Einstein College of Medicine, Yeshiva University, Bronx, NY
Assistant Professor of Medicine, teaching Fellows and House Staff. Laboratory studies
North Shore-LIJ Hofstra School of Medicine, Hempstead, NY
Assistant Professor of Medicine, teaching Fellows and House Staff. Laboratory studies

RESEARCH EXPERIENCE:

North Shore-LIJ Health System, Division of Allergy/Immunology, New Hyde Park, NY
Elmezzi Scholar (Graduate Student in Molecular Medicine), Exploring TH2/TH1
cytokine and chemokine expression from T-cells and macrophages in HPV-induced recurrent respiratory papillomatosis and cervical cancer. HPV peptides response to anergy. Role of various antigen presenting cells in HPV-associated disease. Fellow-In-Training, Continued projects began as a Research Fellow.
Research Fellow, 1) Exploring TH2/TH1 balance in HPV-induced recurrent respiratory
papillomatosis by producing and maturing myeloid-derived dendritic cells and measuring their morphology and function via flow cytometry, immunohistochemistry, and microarrays as well as measuring cytokine, chemokine, and prostoglandin production via ELISA, and rtPCR. Associations with HLA alleles, COX-2 expression, and other variables is being performed. 2) Studying qualitative humoral deficiency post-chemotherapy in children with ALL. 3) Producing, screening, and cloning B-cell-derived, rheumatoid factor (RF)-specific hybridomas and investigating these clones IgG isotype specificity by ELISA in order to understand the peripheral regulation of RF. 4) Analyzing data, writing and editing NIH, private and internal grants, manuscripts, and institutional review board proposals. Resident Rotation, Stimulated isolated PBMC with Ginseng, extracted RNA and
performed rtPCR to amplify clones which were screened on a microarray and analyzed in
order to determine the effects of Ginseng on immune modulation. Designed data coding
and statistical analysis schema with a Fellow planning a clinical asthma study.
Medical Student Rotation, Designed sequential PCRs to create a fusion gene containing
HPV6 and 11 E6 or E7 and the HIV tat gene for use in ongoing research. Performed
multiple sequence alignment of human and chimpanzee IL-2 promoter regions. Designed
and conducted several other PCR experiments.
University of Missouri, Kansas City, MO
Research Associate, Planned, initiated and conducted molecular biological research to
localize pro-opiomelanocortin (POMC), the pre-prohormone for ß-endophine, ß-
lipotropin, and ACTH in the heart of rat models. Localize POMC in the nucleus of the
solitarius tract in humans. Taught medical students, graduate students, and anesthesia
fellows molecular biological techniques and theory. Coordinated lab purchasing and lab
activities. Employed immunohistochemical, reverse transcriptase PCR, northern blotting
and in situ hybridization techniques.
Children’s Mercy Hospital, Kansas City, MO
Research Assistant, Planned, organized, & conducted molecular biological research to
characterize the allergens of a common mold, Alternaria Alternata, in the laboratory of
Charles Barnes, PhD. & Jay Portnoy, MD. Initiated experiments comparing different
strains of Alternata through northern blotting techniques. Standardized & correlated results
with 5.8S rRNA probing & sandwich ELISA assays respectively. Created & analyzed
probes using PCR & DNA sequencing.
Research Assistant, Examined molecular differences in strains of Alternata through RNA
extraction & northern blotting work. Created new probes to identify the allergen via PCR.
Manipulated gene products & vectors creating an allergenic fusion protein. Analyzed
DNA sequencing results & searched GeneBank.
Research Assistant, Initiated the use of molecular biological techniques in this laboratory
in order to characterize Alternata. Observed and studied different techniques and taught
co-workers methods such as PCR, RNA extraction. Created and screened a cDNA library.
Published and presented three abstracts at the 1993 AAAI meeting.

ACTIVITIES:

Hebrew College, Boston, MA
My Jewish Learning, Inc. New York, NY
Coordinator, Shamash: The Jewish Network <http://shamash.org>
Coordinate staff and volunteers, install and maintain UNIX software, provide technical
support for users, create and maintain web content and Internet databases, create,
administer and oversee 600+ mailing lists, author application documentation. Coordinate
fundraising and budgets, supervise paid technical and administrative staff, create new
projects, and maintain current projects. Report to lay leadership committee as well as
organizational professional administration. Skilled in apache, ListProc/ListServ software,
UNIX shell programming, help desk support, system administration.
Northeast Osteopathic Medical Education Network (NEOMEN) OPTI, Biddeford, ME
NEOMEN Southern Region, Resident Representative (2000-2003)
Video Conference Lecture Series, Seton Hall Univ Site Coordinator (2001-2003)
NEOMEN Board of Governors (BOG), Member (2002-2003)
NEOMEN BOG Education Program Committee, Member (2002-2003)
Center for Research in Education Network (CREN), Washington DC
ListProc Support Staff, Created documentation, frequently asked questions web pages,
and small support applications for the ListProc software. Created an automatically-
updated, web-accessible, fully-searchable archive of all mailing list correspondence.
Responded to questions from site administrators using ListProc and worked with
product developers to identify and fix software bugs and beta test releases.
Kansas City University of Medicine and Biosciences College of Osteopathic Medicine
Vice President, Student Senate. Coordinated senate activities, planned meetings,
assisted member groups, assisted in financial allocations, maintained open lines of
communication between the study body and the administration, rewrote senate
constitution, organized elections.
Founder and Chairperson, Computer Issues committee. Created a committee to
bring student/faculty input to campus technologies needs. Worked closely with the
director ot Network Services to prioritize campus technologies needs. Founded the
student web site, worked with Network Services to hire additional full time
technology staff, and to update and reorganize institutional hardware and software to
improve technological educational resources.
Class Representative, Student Senate. Represented the class of 2000 in Senate
events. Coordinated a voter registration drive, revised the constitution, worked
closely with administration
Committee Member, KCUMB-COM Syllabus committee Reviewed and evaluated
syllabi for completeness and content in a faculty/student committee.
Brandeis University, Waltham, MA
Chairperson, Project Unity. Initiated coalition building and mediated in conflict
resolution to break down stereotypes. Coordinated & supervised programs about
different movements in Judaism. (1994-1995)
Teaching Assistant & Computer Specialist. Transferred the 1990 National Jewish
Population Survey statistical dataset to a user- friendly student interface. Re-coded
statistical data. Planned computer assignments, taught several classes. (1994-1995)
Founder and Chairperson, Hillel Internet System, Established and maintained
web, gopher and mailing list systems. Trained personnel to manage these systems.
Created e-mail distribution lists for each of the 40 Hillel organizations based on
manipulations of the Hillel database. (1993-1995)
Hillel President, Oversaw the management of 40 constituent groups, an executive
board, and programs involving over 600 participants. Coordinated activities, delegated
responsibility, engaged in leadership development, served in conflict resolution,
advocacy, advisory, and crisis management roles. Approximately 40 hours/week was
spent performing these duties. (1993-1994)

HOSPITAL PRIVILEGES:

North Shore University Hospital, Manhasset, NY (Pediatrics, Internal Medicine)
Long Island Jewish Medical Center, New Hyde Park, NY (Internal Medicine)
Cohen Children’s Medical Center, New Hyde Park, NY
(Pediatrics)
Forest Hills Medical Center, Forest Hills, NY (Pediatrics, Internal Medicine)

BOARD CERTIFICATIONS:
Diplomat, National Board of Osteopathic Medical Examiners (2002)
Board Eligible, American Board of Internal Medicine (2003)
Board Eligible, American Osteopathic Board of Internal Medicine (2003)
Board Eligible, American Board of Allergy and Immunology (2006)
Credentialed, American Academy of HIV Medicine (2012)
PROFESSIONAL MEMBERSHIPS:
National:
Member, American Academy of HIV Medicine (2011-) Member, Federation of Clinical Immunology Societies (2010-) Member, Clinical Immunology Society (2010-) Member, American Academy of Allergy, Asthma & Immunology (2003-) Member, American College of Allergy, Asthma & Immunology (2004-) Member, American Medical Association (1996-) Member, American Osteopathic Association (1996-) Member, New York Allergy and Asthma Society (2004-) Member, New York Chapter of American College of Physicians (2005-) Member, New York Medical Society (2006-) Member, New York State Osteopathic Medicine Society (2003-) Regional:
Member, Nassau County Medical Society (2006-) Member, Long Island Allergy and Asthma Society (2005-) PROFESSIONAL LEADERSHIP:
National:
Committee Member, Basic and Clinical Immunology Cmte, American College of Allergy International: Board Member, Allergists for Israel (2005-)

INVITED PRESENTATIONS:

1. HIV in Adolescents. CME Conference: Current Issues in Pediatric and Adolescent Gynecology. North Shore University Hospital. Manhasset, NY. Nov 2, 2011. 2. Allergic Diseases: The Molecular Immunology of Atopy. Internal Medicine Grand Rounds. North Shore- LIJ Health System. New Hyde Park, NY. Sept 22, 2011. 3. Management and Testing for HIV in 2011. Pediatric Grand Rounds, Cohen Children’s Medical Center Long Island Jewish Medical Center. New Hyde Park, NY, January 14, 2011. 4. Management and Testing for HIV in 2011. Pediatric Grand Rounds, North Shore University Hospital, 5. An update in Clinical Immunology in 2011. Nassau County Association of School Nurses, Bellmore, NY, 6. An update in HIV management in 2010. New York College of Osteopathic Medicine, 2010, Westbury, 7. The role of immune defects in Common Granulomatous Disease and Recurrent Respiratory Papillomatosis. Joint conference of the American College of Allergy Asthma and Immunology and the Israeli Academy of Allergy and Clinical Immunology. December 2008. Jerusalem, Israel. 8. Human Papillomavirus causes a TH2-like Chemokine Predominance in Recurrent Respiratory Papillomatotosis (RPR). Presented at the ST*AR program, Am Acad Allergy Asthma Immunology 2008,
Philadelphia, PA.
9. CD4+Foxp3+CD127+low T-regulatory cells are increased in HPV infected Papillomas in patients with Recurrent Respiratory Papillomatosis (RRP) 24th International Papillomavirus Conference and Clinical Workshop, Bejing, China, 2007. 10. New Developments in HIV Management and Therapy. Grand Rounds, North Shore University Hospital, 11. Evaluation of Atypical Cystic Fibrosis (CF) in Chronic Sinusitis Patients: A Case Report. American College Allergy Asthma Immunology Philadelphia, PA, Nov 13, 2006. 12. Increased Type 2 Chemokine Expression in Recurrent Respiratory Papillomatosis (RRP). 23rd International Papillomavirus Conference, Prague, Czech Republic, Sept 3-7, 2006. (Presented by my mentor, due to travel cost limitations) 13. Northern Blot Identification of Alt aI mRNA in 8 strains of Alternaria, Amer. Acad. Allergy Asthma PUBLICATIONS (in chronological order):
ORIGINAL COMMUNICATIONS IN REVIEWED JOURNALS:

1. Hatam LJ, DeVoti JA, Rosenthal DW, Steinberg BM, Abramson A, Bonagura VR. Immune Suppression in Premalignant Respiratory Papillomas: Enriched Functional CD4+Foxp3+ Regulatory T-cells And PD-1/PD-L1/L2 Expression. Clinical Cancer Res. 2012. Epub 2012 Feb9. doi: 10.1158/1078-0432.CCR-11-2941 2. James EA, DeVoti JA, Rosenthal DW, Hatam LJ, Steinberg BM, Abramson A, Kwok WW, Bonagura VR, Papillomavirus-Specific CD4+ T-cells Exhibit Reduced STAT-5 signaling and Altered Cytokine Profiles in Patients with Recurrent Respiratory Papillomatosis. Journal of Immunology. J Immunol. 2011 Jun 1;186(11):6633-40. Epub 2011 Apr 29. PMID: 21531896. PMCID: PMC3124771 3. Meth MJ, Rosenthal DW, Bonagura VR. Subcutaneous immunoglobulin infusion to treat infants and toddlers with antibody deficiencies. Ann Allergy Asthma Immunol. 2010 Aug;105(2):187-8. PubMed PMID: 20674834. 4. Bonagura VR, Hatam LJ, Rosenthal DW, de Voti JA, Lam F, Steinberg BM, Abramson AL. Recurrent respiratory papillomatosis: a complex defect in immune responsiveness to human papillomavirus-6 and -11. APMIS. 2010 Jun;118(6-7):455-70. Review. PubMed PMID: 20553528. 5. Bonagura VR, Du Z, Ashouri E, Luo L, Hatam LJ, DeVoti JA, Rosenthal DW, Steinberg BM, Abramson AL, Gjertson DW, Reed EF, Rajalingam R. Activating KIR receptors 3DS1 and 2DS1 protect against developing the severe form of recurrent respiratory papillomatosis. Human Immunology. 2010. February; 71(2): 212. 6. Schuval SJ, Gavin Schwarz G, Leonov A, Rosenthal DW. Serious Infection and “Iatrogenic” Immunodeficiency in a Patient treated with Rituximab?[E-letter], Pediatrics (March 8, 2009) http://pediatrics.aappublications.org/cgi/eletters/123/1/e159 7. DeVoti JA, Rosenthal, DW, Wu, R, Abramson, AL, Steinberg, BM, Bonagura, VR. Immune Dysregulation and Tumor-Associated Gene Changes in Recurrent Respiratory Papillomatosis: A Paired Microarray Analysis. Molecular Medicine. Sept/Oct 2008: 14 (9-10) 608-617. 8. Bonagura VR, Marchlewski R, Cox A, Rosenthal DW. Biologic IgG level in primary immunodeficiency disease: the IgG level that protects against recurrent infection. J Allergy Clin Immunol. 2008 Jul;122(1):210-2. DOI: 10.1016/j.jaci.2008.04.044 9. Brodtman DH, Rosenthal DW, Redner A, Lanzkowsky P, Bonagura VR: Immunodeficiency In Children with Acute Lymphoblastic Leukemia, After Completion of Modern Aggressive Chemotherapeutic Regimens. J. Pediatrics. May 2005. 145(5). 654-661. 10. Bonagura VR, Vambutas A, DeVoti JA, Rosenthal DW, Steinberg BM, Abramson AL, Shikowitz MJ, Gjertson DW, Reed EF: HLA Alleles, IFN-g Responses to HPV-11 E6, and Disease Severity in Patients with Recurrent Respiratory Papillomatosis. Human Immunology. 2004. 65 (8): 773-782. 11. DeVoti JA, Steinberg BM, Rosenthal DW, Hatam L, Vambutas A, Abramson AL, Shikowitz MJ, Bonagura VR. Failure of Gamma Interferon, but not Interleukin-10 Expression in Response to Human Papillomavirus Type 11 E6 Protein in Respiratory Papillomatosis. Clinical and Diagnostic Laboratory Immunology. 2004. 11(3). 538-547. 12. Millington WR, Rosenthal DW, Unal CB, Nyquist-Battie C. Localization of Pro-opiomelanocortin mRNA transcripts and peptide immunoreactivity in rat heart. Cardiovascular Research 1999. 43(1):107-116 13. Rosenthal D, Pacheco F, Landuyt J, Barnes C, Portnoy J. Northern blot identification of mRNA containing sequence for protein allergen, Alt a1, in eight strains of Alternaria alternata. Annals of Allergy, Asthma and Immunology: 1998; 80(6). 471-5 14. Barnes CS., Pacheco F, Landuyt J, Rosenthal D, Hu F, Portnoy J. Production of a recombinant protein from Alternaria containing the reported N-terminal of the Alt A1 allergen. Advances in Experimental and Medical Biology 1996. 409: 197-203 PUBLISHED ABSTRACTS
1. Jongco AM, DeVoti JA, Sarnataro K, Diaz JM, Rosenthal DW, Bonagura VR. Investigating the Role of MicroRNAs (MIRs) in the Dysregulated immune response Underlying Recurrent Respiratory Papillomatosis (RRP) caused by Low Risk Human Papillomaviruses (LR HPV). 2012 CIS Annual Meeting: Primary Immune Deficiency Disease North American Conference May 17 - 20, 2012 (Annual Meeting Abstract Submission). 2. Helfner L, Jongco A, Schuval SJ, Rosenthal DW. Successful Repeated Desensitization to High Dose Methotrexate. Annals of All Asth Imm. 107:5(Supplement 1): A76. Presented at the Am Coll All Asthma Imm, Nov 5, 2011. Boston, MA. 3. Katz L, Sporter RJ, Cavuto MA, Bonagura VR, DeVoti JA, Rosenthal DW. Variability of Commercially Available Sesame Skin Prick Test Reagents. Journal of Allergy and Clinical Immunology. 127 (2), Supplement: AB185. DOI: 10.1016/j.jaci.2010.12.734 Presented at the Am Acad All Asthma Imm. Mar 2011. 4. Kuryan J, Jhaveri KD, Wang X, Colter C, Rosenthal DW. Immune Complex Variant C1Q Nephropathy in a Patient with Congenital HIV. Annals of All Asth Imm, 105 (5:Supplement 1): A72. Presented at the Am Coll All Asthma Imm, Nov 13, 2010. Phoenix, AZ. 5. James EA, Devoti JA, Rosenthal DW, Hatam LJ, Steinberg BM, Abramson A, Bonagura VR. Human Papillomavirus 6/11-Specific T-cells Binding Class II Tetramer-E2/E6 Complexes elicit reduced IFN-γ. 26th Annual International Papillomavirus Conference, Montreal, Canada. 112 6. Rosenthal DW, Devoti JA, Steinberg BM, Abramson A, Bonagura VR. Alteration of Plasma TH2- chemokines in Patients with Recurrent Respiratory Papillomatosis (RRP) treated with Celecoxib. 26th Annual International Papillomavirus Conference, Montreal, Canada.149 7. Devoti JA, Rosenthal DW, Diaz J, Abramson A, Bonagura VR. Select Micro-RNA's (miRNA's) are Upregulated in HPV-6 and -11 Induced Recurrent Respiratory Papillomatosis (RRP). 26th Annual International Papillomavirus Conference, Montreal, Canada. 150. 8. Bonagura VR, Hatam LJ, DeVoti JA, Rosenthal DW, Steinberg BM. Defective Natural Killer (NK) Cell Function In Patients With Recurrent Respiratory Papillomatosis (RRP) infected with HPV-6/11. 26th Annual International Papillomavirus Conference, Montreal, Canada. 184 9. Bonagura VR, Du Z, Luo L, Gjertson D, Hatam LJ, DeVoti JA, Rosenthal DW, Reed E, Rajalingman R. KIR3DS1, KIR2DS1, and KIR2DS5 protect against the development of severe recurrent respiratory papillomatosis (RRP) in HPV-6/11-infected patients. 26th Annual International Papillomavirus Conference, Montreal, Canada. Oral Presentation. July 6, 2010 10. Sporter R, Meyer E, Rosenthal DW, Highly Active Anti-Retroviral Treatment (HAART) Medication Adherence in Adolescents with Perinatally-Acquired HIV Infection J Allergy Clinical Immunology.2010. 125(2): AB78. Presented at the Am Acad Allergy Asthma Immunology 2010, New Orleans, LA. 11. Rosenthal DW, Devoti JA, Bonagura VR, TH2-like Chemokine Predominance in Recurrent Respiratory Papillomatotosis (RPR) Does Not Originate from Peripheral Blood Mononuclear Cells (PBMC) J Allergy Clinical Immunology.2010. 125(2): AB144. DOI: 10.1016/j.jaci.2009.12.563 Presented at the Am Acad Allergy Asthma Immunology 2010, New Orleans, LA. 12. James E, ,DeVoti JA, Rosenthal DW, Hatam LJ, Steinberg BM, Abramson A, Kwok WW, Bonagura VR Human Papillomavirus (HPV)-Specific T-cells Recognizing Dominant E2/E6 Epitopes Elicit Reduced IFN-γ in Patients with Recurrent Respiratory Papillomatosis (RRP) J Allergy Clinical Immunology.2010. 125(2): AB77. DOI: 10.1016/j.jaci.2009.12.303 Presented at the Am Acad Allergy Asthma Immunology 2010, New Orleans, LA 13. Leonov A, Rosenthal DW, Bonagura VR., Decreased Marginal Zone B-cell (MZB) Expression in Common Variable Immunodeficiency (CVID) Does Not Predict Deficienct IgM Isohemagglutinin (IgMIH) Production. J Allergy Clinical Immunology.2010. 125(2): AB13. DOI: 10.1016/j.jaci.2009.12.080 Presented at the Am Acad Allergy Asthma Immunology 2010, New Orleans, LA. 14. Diaz J, Devoti JA, Rosenthal DW, Bonagura VR , Select Micro-RNAs (miRs) Are Upregulated in Human Papillomavirus (HPV) 6 and 11-Induced Recurrent Respiratory Papillomatosis (RRP) J Allergy Clinical Immunology.2010. 125(2): AB76. DOI: 10.1016/j.jaci.2009.12.298 Presented at the Am Acad Allergy Asthma Immunology 2010, New Orleans, LA. 15. Bonagura VR, Hatam LH, Rosenthal DW, Devoti JA, Steinberg BM, Abramson A, Defective NK Cytolysis in Recurrent Respiratory Papillomatosis (RRP) J Allergy Clinical Immunology.2010. 125(2): AB76. DOI: 10.1016/j.jaci.2009.12.299 Presented at the Am Acad Allergy Asthma Immunology 2010, New Orleans, LA. 16. Mithani S, Farzan S; Rosenthal DW, Kaplan B, An Atypical Clinical Presentation and a Novel Gene Mutation in a Patient with Hyper-IgE Syndrome. Annals of Allergy, Asthma & Immunology 2009 103(5), A101. Presented at the American College of All Imm, 2009, 17. Sharif NA, Rosenthal DW, Schuval, S. Undetectable HIV Infection in a 12 year old Perinatally-Infected Child. Annals of Allergy, Asthma & Immunology 2009 103(5), A101. Presented at the American College of All Imm, 2009, 18. Siegel SA, Rosenthal DW, Bonagura VR. Biologic IgG Level (BIgGL): One Size Does Not Fit All. J Allergy Clinical Immunology.2009. 123(2): S12. DOI: 10.1016/j.jaci.2008.12.057 Presented at the Am Acad Allergy Asthma Immunology 2009, Washington DC. 19. Alexis A, Safier B, Rosenthal DW, Cavuoto MA. Sesame Food Allergy and Sensitization in Children: A Growing Concern in the USA. J Allergy Clinical Immunology.2009. 123(2): S32. Presented at the Am Acad Allergy Asthma Immunology 2009, Washington DC. 20. Meth MJ, Serota M, Rosenthal DW, Santiago MT, Cavuoto MA. High Frequency of CF Transmembrane Conductance Regulator (CFTR) Mutations in a Population with Persistent Asthma and/or Chronic Rhinosinusitis. J Allergy Clinical Immunology.2009. 123(2): S159. Presented at the Am Acad Allergy Asthma Immunology 2009, Washington DC. 21. Bonagura VR Du Z, Luo L, Gjertson D, Hatam LJ, Devoti JA, Rosenthal DW, Reed E, Rajalingam R. KIR3DS1, KIR2DS1, and KIR2DS5 Protect Against the Development of Severe Recurrent Respiratory Papillomatosis (RRP) in HPV-6/11-Infected Patients. J Allergy Clinical Immunology.2009. 123(2): S165. DOI: 10.1016/j.jaci.2008.12.620 Presented at the Am Acad Allergy Asthma Immunology 2009, Washington DC. 22. Siegel, S, Schuval SJ, Rosenthal DW, Neurosyphilis as a presentation of HIV infection in an adolescent. Annals of Allergy, Asthma & Immunology 2009; 102(1):A95. Presented at the American College of All Imm, 2008, Seattle, WA. 23. Rosenthal DW, Devoti, JA, Schmidtmayerova H, Steinberg, BM, Bonagura VR. Human Papillomavirus causes a TH2-like Chemokine Predominance in Recurrent Respiratory Papillomatosis (RRP). J Allergy Clinical Immunology.2008. 121(2): S15. DOI: 10.1016/j.jaci.2007.12.062 Presented at the Am Acad Allergy Asthma Immunology 2008, Philadelphia, PA. 24. Bonagura VR, James E, DeVoti JA, Rosenthal DW, Hatam LJ, Steinberg BM, Abramson A, Kwok WW. Class II MHC Tetramer Guided Epitope Mapping (TGEM) of E6/E2-Specific T-Cells in Patients with Recurrent Respiratory Papillomatosis (RRP): Developing a Therapeutic Vaccine. J Allergy Clinical Immunology.2008. 121(2): S166. DOI: 10.1016/j.jaci.2007.12.613 Presented at the Am Acad Allergy Asthma Immunology 2008, Philadelphia, PA. 25. Hatam LJ, Rosenthal DW, DeVoti JA, Lam F, Abramson A, Steinberg BM, Bonagura VR. CD4+Foxp3+CD127+low T-Regulatory Cells are Increased in HPV Infected Papillomas in Patients with Recurrent Respiratory Papillomatosis (RRP). J Allergy Clinical Immunology 2008. 121(2): S211. DOI: 10.1016/j.jaci.2007.12.789 Presented at the Am Acad Allergy Asthma Immunology 2008, Philadelphia, PA. 26. Siegel, S., Katz, LA., Rosenthal, DW. Perinatally infected HIV(PIHIV) patients fail to mount sustained anti-Hepatitis B surface antibody titers(HBsAb) after vaccination. J Allergy Clinical Immunology. .2008. 121(2): S229. Presented at the Am Acad Allergy Asthma Immunology 2008, Philadelphia, PA. 27. Rosenthal DW, Schmidtmayerova, H, Steinberg, BM, Bonagura, VR. Recurrent Respiratory Papillomatosis (RRP): A Type 2 T-cell Disease. 24th International Papillomavirus Conference and Clinical Workshop, Bejing, China, 2007. 28. Hatam L, Rosenthal DW, DeVoti JA, Lam F, Abramson A, Steinberg BM, Bonagura VR. CD4+Foxp3+CD127+low T-regulatory cells are increased in HPV infected Papillomas in patients with Recurrent Respiratory Papillomatosis (RRP) 24th International Papillomavirus Conference and Clinical Workshop, Bejing, China, 2007. 29. Bonagura VR, James E, DeVoti JA, Rosenthal DW, Hatam L, Abramson A, Steinberg BM, Kwok WW. Class II MHC Tetramer Guided Epitope Mapping (TGEM) Of E6/E2-Specific T-cells in Patients with Recurrent Respiratory Papillomatosis (RRP): developing a therapeutic vaccine. 24th International Papillomavirus Conference and Clinical Workshop, Bejing, China, 2007. 30. Devoti, JA, Rosenthal DW, Wu R, Abramson A, Steinberg, BM, Bonagura VR. Chemokine Mediated Immune Evasion by Human Papillomavirus (HPV) in Recurrent Respiratory Papillomatosis (RRP). 24th International Papillomavirus Conference and Clinical Workshop, Bejing, China, 2007. 31. Silverman, SP, Rosenthal, DW, Ponda, P, Bonagura VR. Hypo-IgM Syndrome: A Secretion Defect? J Allergy Clinical Immunology.2007, 119 (1) S14. DOI: 10.1016/j.jaci.2006.11.072 . Presented at the Am Acad Allergy Asthma Immunology 2007, San Diego, CA. 32. Rosenthal, DW, Colter, C, Maroldo, L, Coakley, E, Schuval SJ. Multidrug-Resistant (MDR) HIV Transmission to a Third Generation Offspring. J Allergy Clinical Immunology.2007, 119 (1) . Presented at the Am Acad Allergy Asthma Immunology 2007, San Diego, CA. 33. Rosenthal DW, DeCelie-Germana J, Bonagura VR. Evaluation of Atypical Cystic Fibrosis (CF) in Chronic Sinusitis Patients: A Case Report. Presented at the Am College Allergy Asthma Immunology 2006, Philadelphia, PA 34. Rosenthal DW, DeVoti JA, Wu R., Schmidtmayerova, Steinberg BM, Bonagura VR. Increased Type 2 Chemokine Expression in Recurrent Respiratory Papillomatosis (RRP). 23rd International Papillomavirus Conference, Prague, Czech Republic, Sept 3-7, 2006 35. Bonagura VR, DeVoti JA, Rosenthal DW, Hatam L, Steinberg BM, Kwok B. Class II MHC Tetramer Identification of HPV-6, E6-specific T-cells. ). 23rd International Papillomavirus Conference, Prague, Czech Republic, Sept 3-7, 2006 36. Rosenthal DW, DeVoti JA, Wu R., Schmidtmayerova, Steinberg BM, Bonagura VR. Recurrent Respiratory Papillomatosis (RRP): Increased TH2-like Chemokine Expression. J Allergy Clinical Immunology. 2006;117 (2): S104. DOI: 10.1016/j.jaci.2005.12.417 Presented at AAAAI 2006. 37. Ponda, P, Rosenthal, DW, Kaplan, B, LoGalbo, P, Schuval, SJ, Torgerson, TR, Ochs, HD, Bonagura, VR. A Case of Immune Dysregulation, Polyendocrinopathy, Enteropathy, X-linked (IPEX) Syndrome without serological evidence of autoimmunity. J Allergy Clinical Immunology. 2006; 117 (2): S289. DOI: 10.1016/j.jaci.2005.12.1090 Presented at AAAAI 2006. 38. Marchlewski R, Rosenthal DW, Bonagura, VR. A Case of Hyper IgM Syndrome with an Intronic Point Mutation at Intervening Sequence 2, Position 16 in Activation-Induced Cytidine Deaminase (AID) Gene. J Allergy Clinical Immunology. 2006; 117 (2): S283. DOI: 10.1016/j.jaci.2005.12.1169 Presented at AAAAI 2006. 39. Rosenthal DW, Colter C, Schuval S. Transmission of Multidrug-resistant HIV to a Third Generation. #P206. Presented at the Am College Allergy Asthma Immunology 2005, Anaheim, CA. 40. Bonagura V, Rosenthal D, Schmidtmayerova H, Steinberg B. Recurrent Respiratory Papillomatosis (RRP): Enriched TH2-like Chemokine 18 (CCL18) Plasma Expression and Disease Severity. Presented, 22th International Papillomavirus Conference. Vancouver, British Columbia, 2005. 41. Rosenthal DW, Schmidtmayerova H, Steinberg BM, et al. Recurrent Respiratory Papillomatosis (RRP): Disease Severity Associates with Enhanced TH2-like Dendritic Cell Chemokine (DC-CK1) Plasma Expression. J Allergy Clinical Immunology. 2005;115(2):S81. DOI: 10.1016/j.jaci.2004.12.336 Presented at AAAAI 2005 42. Hadjiev B, Devoti JA, Rosenthal DW, Vambutas A, Steinberg BM, Bonagura VR. Recurrent Respiratory Papillomatosis (RRP) TH2-like T-Cell Polarization Induced by Human Papillomavirus (HPV)-11, Early Protein-6 (E6). J Allergy Clinical Immunology. 2005;115(2):S135. DOI: 10.1016/j.jaci.2004.12.552 Presented at AAAAI 2005 43. Rosenthal DW, Devoti JA, Steinberg BM, Bonagura VR, HPV-6 Up-Regulates Cyclooxygenase-2 in Recurrent Respiratory Papillomatosis (RRP). J of Allergy and Clinical Immunology 2004, 113 (2). S213. DOI: 10.1016/j.jaci.2004.01.207 Presented Amer. Acad. Allergy Asthma Immunol 2004. 44. Hu F; Rosenthal D, Barnes C, Landuyt J, Pacheco F, Portnoy J. A 15 kD protein containing sequence for an Alt a1 epitope. ). J of Allergy and Clinical Immunology 1997, 99 (1S2). S1586. Presented at the Amer. Acad. Allergy Asthma Immunol 1997. 45. Rosenthal DW, Manning AB, Resch GE, Millington WR, Manalo MJ. Localization of -N-acetyl-- endorphin immunoreactivity and pro-opiomelanocortin mRNA in cardiovascular nuclei of rat and human brain. Society of Neuroscience 1996; 22(2):1308. 46. Manalo MJ, Manning AB, Rosenthal DW, Fibuch EE, Handler MS, Millington WR. Localization of Opioid and Non-Opioid ß-Endorphin Peptides and Pro-opiomelanocortin mRNA in Cardioregulartory Nuclei of Rat and Human Brain. Midwest Anesthesiology Residents Conference 96. Apr 1996. 47. Barnes CS, Pacheco F, Landuyt J, Rosenthal D, Hu F, Portnoy J. Production of a recombinant protein from Alternaria containing the reported N-Terminal of the Alt A1 Allergen. New Horizons in Allergy Immunotherapy ed. Sehon A, Hayglass K, Kraft D. Plenum Press. New York and London. 1996. 48. Hu F, Pacheco F, Landuyt J, Rosenthal D, Barnes C, Portnoy J. IgE Binding to a Synthetic Recombinant Peptide Containing the N-Terminal AA Sequence of Alt A1. J Allergy Clinical Immunology. 1995; 95 (1):166. Presented Amer. Acad. Allergy Asthma Immunol 1995. 49. Rosenthal D, Crenshaw R, Esch R, Pacheco F, Landuyt J, Hu F, Barnes C, Portnoy J. Northern Blotting Studies on Alt AI mRNA and 5.8S rRNA in Nine Strains of Alternaria. J Allergy Clinical Immunology 1995;95 (1): 166. Presented Amer. Acad. Allergy Asthma Immunol 1995. 50. Portnoy J, Pacheco F, Rosenthal D, Landuyt J, Barnes C. Partial Amino Acid Sequence for the 31kD Allergen Alt a1. J Allergy Clinical Immunology 1994;93(1):189. Presented Amer. Acad. Allergy Asthma Immunol 1994. 51. Pacheco F, Rosenthal D, Portnoy J, Landuyt J, Barnes C. Production of a fusion protein containing recombinant alt a1, a major Alternaria allergen. J Allergy Clinical Immunology 1994;93(1):208. Presented Amer. Acad. Allergy Asthma Immunol 1994. 52. Barnes C, Rosenthal D, Pacheco F, Landuyt J, Portnoy J. Studies on the mRNA of Alternaria allergen Alt aI by Polymerase Chain Reaction. J Allergy Clinical Immunology 1994;93(1):207. Presented Amer. Acad. Allergy Asthma Immunol 1994. 53. Rosenthal D, Crenshaw R, Esch R, Pacheco F, Landuyt J, Barnes C, Portnoy J., Northern Blot Identification of Alt A1 Messenger-RNA in 8 Strains of Alternaria. Allergy Clinical Immunology 1994;93(1):232. Presented Amer. Acad. Allergy Asthma Immunol 1994. 54. Rosenthal D, Portnoy J, Horner S, Pacheco F, Landuyt J, Barnes C. Production of recombinant Alternaria allergens. J Allergy Clinical Immunology 1993;91:279. Presented Amer. Acad. Allergy Asthma Immunol 1993. 55. Portnoy J, Rosenthal D, Horner S, Pacheco F, Landuyt J, Barnes C. Polymerase chain reaction (PCR) detection of DNA for the Alternaria allergen Alt a1. J Allergy Clinical Immunology 1993;91:188. Presented Amer. Acad. Allergy Asthma Immunol 1993. 56. Barnes C, Rosenthal D, Pacheco F, Landuyt J, Portnoy J. Structural Determination of a human IgE recognized protein from Alternaria alternata. FASEB Journal 1993;7(7):A1281.
DATABASE ENTRIES
Alternaria alternata Alt a1 mRNA, complete cds. Genebank Accession AAU62097, 506 bp mRNA.
Alternaria alternata Alt a1, Protein Accession 1421808. 135 aa protein.
REFERENCES AVAILABLE UPON REQUEST

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