Evaluation of publications – Role of impact factor I would like to express my views on the
in a journal with low impact factor, both
editorial (Curr. Sci., 2000, 78, 1177–
1178) regarding evaluation of scientists
according to the citation number of their
tion of an article that is above the aver-
age of a low impact factor journal. If we
I still feel that the impact factor of the
these publications, we could see that an
journal where they publish their work is
average article in a journal with a high
impact factor will be far better than that
Optimal publication lists The editorial on ‘The impact of publica-
tion lists’ raises issues central to the
the problem. In their deluge, as Balaram
hints1, the original papers are ‘forgot-
ten’ and ‘little clubs of scientists who
tice to the contributions from the devel-
physicians, scientists and ‘vaidyas’
said, ‘Ashok, in Clinical Pharmacology
citation and recognition. These pioneers
current ‘molecular biology dominant’
has to be one-third of what we’ve actu-
in the politics of research. Table 1 lists
ally done’. I liked the idea, more due to
of supposedly ‘low impact value’, but
Several ‘senior’ Indian scientists, with
root plant of India, either ignored or ridiculed by scientists for decades, were
Table 1. Some major research contributions from India in life sciences
dispelled with the isolation and identifi-cation of its active alkaloid.’.
Sanskrit and local languages, that exist
all over India. Recently, the Department
efforts to get these translated into Eng-
lish, permitting critical review for their
tioned, ‘Books are not absolutely dead
things, but do contain a potency of life
cacy and extinction of that living intel-
lect that bred them’. Books on medicinal
plants by Desai3, Pade4, Jaikrishna Indraji5,
CURRENT SCIENCE, VOL. 79, NO. 2, 25 JULY 2000
CORRESPONDENCE etc. though hardly cited, are major research
6. Siddiqui, S. and Siddiqui, R. H., J. In-
13. Vaidya, A. B., Rajagopalan, Mankodi,
resources for life sciences. Innumerable
dian Chem. Soc., 1931, 8, 667.
7. Sen, G. and Bose, B. K., Indian Med.
Purohit, A. V. and Wadia, N. H., Neu-
cally investigated and developed; molecu-
rol. India, 1978, XXVI, 171–175.
8. Chopra, R. N., Bose, B. C., Gupta, J. C.
14. Pandey, V. N. and Chaturvedi, G. N.,
and Chopra, I. C., Indian J. Med. Res.,
J. Res. Indian Med., 1970, 5, 1–24.
1942, 30, 319.
15. Bordia, A. et al., Atherosclerosis, 1977,
1. Balaram, P., Curr. Sci., 2000, 78, 1177–
9. Mehta, D. J., Sheth, U. K. and Deliwala,
C. V., Nature, 1960, 187, 1034.
2. Davis, R. E., Perspect. Biol. Med.,
10. Kothari, M. L., Vaidya, A. B., Doshi,
1983, 26, 198–203.
J. C. and Sheth, U. K., J. Assoc. Physi-
3. Desai, V. G., Aushadhi Sangrahas,
cians India, 1966, 14, 221–222.
11. Vaidya, R. A., Aloorkar, S. D., Rege,
4. Pade, S. D., Aryabhishak, Sastu Sahitya
Sheth, A. R. and Pandya, S. K., Fertil.
5. Jaykrishna Indraji, B. Y., Jaikrishna Steril., 1978, 29, 632. Indraji Vanaspatishashtra, Pravin
12. Bhargava, K. P. and Singh, N., Indian J. Med. Res., 1981, 73, 443. On the quality of students’ seminars: The singer or the song? While discussing the syllabus for M Sc
tal, there is no other means by which we
of the talks had any discussion at all and
could consider the course useful or not.
teach students to be scientific. Various
This lack of participation included those
and courses on scientific writing and/or
dents also participated for daily assess-
The focal question soon developed. If one person talked and twenty listened,
latter since, over the years these courses
what is the role of these twenty people?
The first answer was that they learn. If
on the students). Here I narrate briefly
they were to learn, would they not do so
why a seminar is necessary: (i) to share
knowledge; (ii) to clarify doubts; (iii) to
docs, etc.; (iv) as a better way of learn-
ing rather than from classes alone; (v) to
papers. It is not a ritual offered at all
understood. It relates to the fact that it
learn to be scientific in a practical way.
meetings? What is the role of the listen-
is a group activity. (Whatever has been
that personal reading is superior to mass
listening if one wants to master details.
> postdocs > students, etc. All agreed
purpose has been, by and large, ignored.
were the faculty. The dilemma started as
students mostly argued that they need to
is no point in their selecting a paper: if
from the course being useless to it being
was useful. Then they were asked: ‘How
have sharing of knowledge as the pri-mary purpose, to what end do they se-
good?’ Apparently less than 10% of the
to improve their final presentation. One
talks had any significant discussion. So
niscient faculty/postdoc combine so that
poorly the first time did better in subse-
CURRENT SCIENCE, VOL. 79, NO. 2, 25 JULY 2000
Any goal that is not taken explicitly into
not to indulge is recklessly by actually
knowledge acquisition, being scientific,
that it would be only fair if all of them
Strangely, nearly every one argued their
accordingly. Is it the fault of the student
enough but to listen to the same stuff 15
up, it was suggested that even the daily
clusions be reached? Is that being scien-
practicals could be taken up as seminars
fragile nerves could bear! By this time,
since a lot of detail could be discussed.
stupor, so diagnostic of ‘seminaritis’, is
realized by every student. That, in itself,
give a scientific talk, and how to break-
up the talk. This has brought us back to
the earlier courses on scientific writing
ask questions. Politeness has a strangle-
doing. Also it was clear that 50% of the
do with a group of people discussing it.
class was very Sicilian in their outlook,
The wrong policy at the right time In the era of globalization and free mar-
need of the hour is therefore to develop
search orientation is palpable among the
are not properly maintained and also not
funded R&D institutes such as IITs to
ing theoretical research in this informa-
Needless to say, the stress should be on
cause of the diverse facilities offered to
CURRENT SCIENCE, VOL. 79, NO. 2, 25 JULY 2000
CORRESPONDENCE IITs and other government-sponsored
institutes/organizations. The fallacy is
earn trivial revenue in comparison to the
cific institutes. This causes an artificial
tions. As a policy, the facilities available
to the research students in all these or-
students instead of getting trained in the
ganizations should be uniform and realis-
tic. For example, in IIT Kharagpur, with
the academic registration fees spiraling
nance fee ever rising, the students here
defeated! If this policy remains, then we
e-mail: pramanik@chem.iitkgp.ernet.inThe Indian Science Congress: Kumbh mela or an effective forum for Science & Technology The rather hesitating final support for
well as electronic media; (iii) Developing
entific discussions involving top leaders
an efficient distribution mechanism of the
sessions by H. S. Virk1, after comparing
ously, greater attention to well-thought
(i) projecting in an effective manner the
for citing (with utmost humility) that in
result, through concerted efforts of the
problems and societal impact of science,
as well as (ii) bringing about a remarka-
nan and others in all the local as well as
coupled with (ii) half an hour’s broad-
session should be an effective force for
the general public, scientists and policy
nurtured by persons like Jawaharlal Nehru.
salary), he had taken for the expenses of
active role with steps like: (i) Publica-
1. Virk, H. S., Curr. Sci., 2000, 78, 1052. Everyman’s Science with short biogra-
2. Prabhu, R., National Herald, 19 March
eral and Sectional Presidents (preferably
with a brief account of their plan); (ii)
them well in time for use by the print as
CURRENT SCIENCE, VOL. 79, NO. 2, 25 JULY 2000
Bt – Boom and bust The development of insect-resistant
trait is recessive, it is difficult to detect
finds that Bt can provoke immunologi-
technology research so far. The Bt
ing recessive alleles are critical as these
transgenic crops derive their resistance
rium Bacillus thuringiensis. Cotton,
or other serious allergic reactions, notes
of a strain selected for its extreme high
study leader Bernstein of the University
resistance to CryIA(c), the Bt gene used
During more than 30 years of use, Bt
ing behind this success is the potential
vulnerability of Bt crops to eventual
However, ‘its potential allergenicity had
were tested for resistance to Bt toxin
health risk to the farmers. Regarding the
using artificial diets in the laboratory.
before and after fields were sprayed and
Bt transgenics will certainly impose a
demonstrated Bt’s allergenicity. Before
selection pressure for pre-existing Bt-
for resistance to Bt toxin, leading Gould
application of the pesticide, 4 of 48 crop
pickers, about 8 per cent, had a positive
frequency of Bt resistance alleles was
skin test to Bt, indicating a sensitivity
after harvesting Bt-sprayed celery, pars-
research definitely illustrates that resis-
berries, half the pickers tested positive.
the evolution of insect adaptation to Bt
That share climbed to 70 per cent within
transgenic plants for potential escapes,
resistance alleles in the population, but
sential to maintain the viability of this
develop Bt sensitivity. Of 34 packers
rely instead on theoretical estimates that
who washed and crated Bt-treated crops,
The excitement over the success of BtBt cotton, the EPA has mandated that
tests after the spraying. Among 44 field
hands working 3 miles away from Bt-
of their crop with non-transgenic cotton
‘refuges from toxin’ will harbour sus-
by Fred Gould et al.1 of North Carolina
ceptible insects and thus retard the evo-
to the strain of Bt sprayed. These anti-
lution of insect resistance against the Bt
in Bt research because it provides the
gene. Gould et al.1 predict that with 4%
Hay fever sufferers, for instance, often
refuge, the Bt cotton could remain effi-
quency of Bt-resistant insects. They
report that in tobacco budworms (Helio-
velop. ‘We’ll take a look at this study’,
this virescens), a major cotton pest, 1 in
resistance to the Bt toxin. This estimate
ties in lesser time. However, the current
Bt cotton has less resistance to other
findings are confirmed, ‘the (pesticides)
sumed in earlier theoretical models, and
industry would be concerned’, he says.
‘In terms of consumer safety, there is
thors predict a boom cycle of only 3–4
probably also reason for concern,’ says
calls this study ‘a timely finding’ which
years for this variety. Again Tabashnik2
‘provides inspiration to plunge ahead’
into larger field tests of resistance man-
deners and others ‘should remember Bt
spect they would other pesticides’, he
Regarding the second aspect, Bt, that
adds. Though the data show that Bt ‘has
1993, before transgenic Bt crops were
sponses’, the pesticide was ‘not horribly
allergenic’, observes coauthor MaryJane
CURRENT SCIENCE, VOL. 79, NO. 2, 25 JULY 2000
CORRESPONDENCE K. Selgrade of the Environmental Pro-
cally manipulate Bt to make it less
5. Baker, B., Organic Farming Research Foundation News Lett., 1999, 6.
1. Gould, F. et al., Proc. Natl. Acad. Sci. USA, 1997, 94, 3519–3523.
2. Tabashnik, B. E., ibid, 3488–3490.
National Research Centre on Plant Bio-
3. Raloff, J., Science News Online, 1999,
Indian Agricultural Research Institute, Bt allergenic is not what makes it pesti-
4. Bernstein, I. L. et al., Environ. Health Perspect., 1999, 107, 575. Chernobyl to shut-down*! According to an announcement made on
debris in an impenetrable shroud, and to
down totally, 14 years after the world's
biggest nuclear disaster; lying bare and
tor. Following the explosion, radioactiv-
ity, equivalent to what could be released
sistent effects of the explosion 14 years
ago. The plant is still generating power.
The workers are confident that the plant
as ‘a positive void coefficient’, which in
getting shut down, there will be loss of
gus (see Figure 1) which entombs reactor
Kirby is ‘despite the brave hopes of the
the legacy of Soviet safety culture itself.
been, there was a tendency to believe in
the invincibility of the state’s technol-
culled and edited from a number of web-sites
http://news.bbc.co.uk. Several sites currently
nuclear industry in the rest of the world
exist which describe the sequence of Cher-
nobyl events and the effects on the offsite
communities and environment. One has to be cautious as some of them, unfortunately,
misrepresent the events, reasons, and conse-
website {http://www.cannon.net/~gonyeau/
Ukrainian capital Kiev, was the scene of
nuclear/chernobyl/htm} are believed to pro-
in Ukraine are scarce, although three of
CURRENT SCIENCE, VOL. 79, NO. 2, 25 JULY 2000
cer, a treatable disease which is rarely
per the IAEA statement. ‘However, with
lated to radiation exposure,’ it said.
nobyl disaster has always been disputed.
tion of the Soviet Union, Russia and its
Figure 1. Chernobyl NPP, view
of the completed sarcophagus seen from the north-
west at ground level showing the northern cascade and western contraforce walls.
Photo credit: The Kurchatov Institute (Russia) and the ISTC-Shelter (Ukraine). 1986
history is concerned, this is not the only
Ukraine. Immediately after the accident,
used to produce electricity. It underwent
amounts of radioactive waste into a lake
recovery and clean-up after the accident
radiation. The exact amount of radiation
tryside can be mentioned in this context.
have had direct effects on their safety.
clear power stations deliver. This means
exposed to radiation. A month later, all
that the operators at the stations can go
the plant – about 116,000 people – had
4% of the 190 tons of uranium dioxide’s
CURRENT SCIENCE, VOL. 79, NO. 2, 25 JULY 2000
NEWS clear waste disposal in general. Storage
facilities for radioactive waste and used
fuel elements are believed to be filled to
shelter is expected to cost. The rest of
sult – because of earthquake, accident
or extreme weather – if the shelter were
completed, in 2005, it is envisaged that
international governments for the urgent
agreed earlier to shut the site but it de-
repairs to sarcophagus, close to the sum
the outlines of the final solution should
Chernobyl accident, the world has yet to
ise to close the power station in 1995 in
announced in a joint statement issued by
during Clinton’s brief visit to Kiev. The
a substantial portion of the fission prod-
ucts in the reactor core and some of the
billion. Ukraine failed to close the plant
ronment. It also represents the first time
hailed it as an ‘historic announcement’
the end of the plant’s natural life in
several years’ time. One of the key ele-
fected by events at a plant. Chernobyl’s
one. ‘The aim of this decision is to re-
K. R. Rao ‘Gokula’, 29/2, 11th Cross Silicon devices with biological functions
The next time you need to spot a rela-
1 of a digital circuit, which is by defini-
tive, or a friend on a railway platform,
by an electronic circuit, whose status is
not respect this distinction. A question
output current, while inactive otherwise.
naturally arises – is it possible to train
No negative current values are possible.
of vision. Talking in terms of electronic
A total of 16 such active circuits, repre-
In a recent publication in Nature1, re-
senting neurons, are placed together in a
tions. If identification of the particular
individual corresponds to the state 0 or
CURRENT SCIENCE, VOL. 79, NO. 2, 25 JULY 2000
itself and onto its nearest and next near-
ferential instabilities which is necessary
for constrained selection, and the possi-
addition, each circuit is connected to a
single central neuron that is trained to
chines. The work of Hahnloser et al.
enough to build integrated circuits that
profile is seen to center on the stimulus
uli amplitudes are vastly different, the
1. Richard, H. R., Hahnloser, Sharpeshkar,
areas while plotting the tuning curve of
Seung, H. S., Nature, 2000, 405, 947–
a cell, and are called population codes.
In the circuit this is achieved by a bal-
Nirupa Sen, T-115, Transit House, JNU Hughes medal for C. N. R. Rao C. N. R. Rao of the Jawaharlal Nehru
tronic and magnetic properties of transi-
ognition of an original discovery in the
field of materials chemistry, particularly
physical sciences, particularly electric-
ity and magnetism or their applications.
Volvo Environment Prize for Amulya Reddy
Amulya Kumar N. Reddy formerly pro-
fessor at the Indian Institute of Science,
CURRENT SCIENCE, VOL. 79, NO. 2, 25 JULY 2000
Disease-oriented Genome Networks Cancer Combating Cancer through Integrated Functional Genomic Research Project RNA Interference as a Tool for Functional Gene Analysis and Therapeutic Gene Silencing in Cancer Research Matthias Truss, Reinhold Schäfer, Christian Hagemeier - Charité - Berlin University Medicine - christian.hagemeier@charite.de Introduction
This Provisional PDF corresponds to the article as it appeared upon acceptance. Fully formattedPDF and full text (HTML) versions will be made available soon. Calf health from birth to weaning. II. Management of diarrhoea in pre-weaned Irish Veterinary Journal 2011, 64 :9 Article type Submission date Acceptance date Publication date Article URL This peer-reviewed article w