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on December 28, 2011
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Dr.dr. Krisni Subandiyah,
The use of glucocorticoids (GCs) or corticosteroids (prednisone or prednisolone) for the treatment of nephrotic syndrome has been started since 1956. International Study of Kidney Disease in Children (ISKDC) sets corticosteroids as first-line treatment for nephrotic syndrome. The majority of idiopathic nephrotic syndrome in children is a steroid-sensitive nephrotic syndrome (SNSS). On SNSS proteinuria, it can rapidly decrease or disappear within 10-14 days after administration of steroids therapy. Treatment of steroid-resistant nephrotic syndrome (SNRS) in children has the results such as not satisfactory, proteinuria remained positive that can lead to loss of protein in the body as well as occurs tubulointersisial fibrosis as an independent pathogenic factor, thus aggravate kidney disease. As stated by dr. Krisni Subandiyah, SP.A (K) in the open examination of her dissertation that was held on Wednesday (28/12), at the 6th Floor Building of Faculty of Medicine (FK) Universitas Brawijaya (UB).
Krisni’s dissertation entitled "The Expression of Receptor Genes of Glucocorticoid-? (GR-?) and GR-? through the Genes Expression of p65 NF-KB and AP-1 in Steroid Resistant Nephrotic Syndrome". From the research finding, along with the results of statistical tests and theoretical studies in this research prove that there is a new finding, an increase expression in GR-? gene which is directly influenced by the decrease level of expression in GR-? gene and the decrease expression of GR-? gene directly affected by the increased expression of GR-? gene. However, it is not through the expression of p65 NF-KB and AP-1 genes on SNRS.
From her research finding, Krisni suggests the need to study the different expressions in GR-?, GR-?, p65 sub unit of NF-KB and AP-1 genes in idiopathic nephrotic syndrome by cohort research method where samples are taken when the patient is diagnosed as nephrotic syndrome before he/she gets corticosteroids. In addition, it needs to do further researches on the role of Jun kinase enzyme, c-fos and c-jun genes in SNRS, the role of I-KB on SNRS, the role of anti-GR-? therapy, anti NF-KB and anti AP-1 on resistant steroid of nephrotic syndrome.
Krisni was born in Surabaya on 19 July, 1964. She graduated from bachelor degree (S1) and Child Specialist Doctor Education in FK Unair, and Child Nephrology Consultant of Child Health Sciences College of Indonesia. The wife of dr. Edi Handoko, Sp.THT-KL(K) is blessed with a son named Rizki Ekaputra Handoko, S.Ked.
The board of examiners composed of Prof. Dr. dr. HMS Chandra Kusuma, SP.A(K) (a promoter), Dr. dr. Loeki Enggar Fitri, M.Kes, SpParK, Dr.dr. Setyawati Karyono, Kes, Prof.dr. M Syaifullah Noer., Sp.A(K), Prof. Dr. dr. Teguh Wahyu Sardjono, DTM&H., M.Sc., SpParK, and Prof. Dr. drh. Aulanni'am, DES. After successfully defending her dissertation in front of the board of examiners, Krisni was entitled with a doctorate of medical science of biomedical interest with GPA 4.00, cum laude predicate and with 3 years 4 months of study period. [mit]
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