Vedani nicola - biscotica

Short form
September 2008



Diploma in Gastroenterology, Milano University
Research and devolopement manager with long lasting experience in
pharmaceutical medicine.
The experience has been gained in hospital and University setting from
1975 –1980 and in pharmaceutical industry from 1981 to the present date.
Dr. Grossi has been directly involved in clinical research either for
registration or marketing support purposes with over sixty products, and in
preclinical research with over ten products.
A substantial part of clinical development activity has been carried out
within Multinational Pharmaceutical Companies.
Presently E.Grossi is heading Medical Department in a large Italian
Pharmaceutical Company ( Bracco SpA) and is Scientific Director of an
important Clinical centre In Milano ( Centro Diagnostico Italiano).

Author of about 150 of publications under the form of full papers among
which more than 90 indexed on PubMed.
Author of about 200 contribution to national or international congresses under the form of abstracts, oral presentations of posters Editor of 7 books or special issues of Scientific Journals Organiser of over 20 Scientific Symposia and 5 International Congresses Invited Speaker on more than 50 conferences inherent to clinical pharmacology and artificial intelligence in medicine at national and international congresses and University settings. Editor of national and international congress proceedings Member of a variety of Scientific Societies and Scientific Boards Author as inventor or co-inventor of ten patents Main therapeutics areas in which dr. Grossi has played a substantial
role in connection with University and Hospital scientific societies:
• Gastroenterology (IBD, GERD, H. Pylori )
• Central Nervous system (Alzheimer Disease, epilepsia, depression)
• Respiratory Diseases (Asthma, Chronic bronchitis, Pneumonia)
• Cardiology ( heart failure, IHD )
• Endocrinology (obesity, thyroid diseases)
• Oncology and palliative care
• Ginecology (Cancer screening and treatment)
• Diagnostic Imaging
• Pharmacoeconomics and Outcome Research
Recent specific research interests
• Quality of life assessment
• Drug compliance
• Communication in Science and Medicine
• Antioxidants and free radicals
• Artificial neural networks

Member of following scientific societies:
• 1976 Italian Society Of Gastroenterology
• 1976 Italian Society of Rheumatology

International Association on Study of Pain • 1991 American Association for the Adv • Società Italiana di Scienze Farmacologiche Applicate • 1986 Italian Society palliative Care Società Italiana Cure Palliative • 1990 Drug Information Association • 1991 European Respiratory Society (ERS) • 1998 Italian Interdisciplinary Network of A • 1998 Società Italiana Attività Regolatorie
• 2000 Semeion Research Centre for Artificial Intelligence in medicine
Recent institutional memberships and appointments:

• Editorial Board , Health Economic Section "MEDIC" Journal
• Editorial Board “International Journal on Drugs and Therapy”
• Coordination of Pharmaceutical Medicine Working Grup within Italian
Society of Applied Pharmacological Science • Advisory Board “Italian Interdisciplinary Network on Alzheimer Disease” • Executive Committee Associazione Geriatria • Contract Professor at Pisa University , Pharmacy Faculty on “The role of Pharmaceutical Industry in drug discovery and development” • Contract Professor at Pavia University, regulatory affairs school • Scientific Director Centro Diagnostico Italiano • Review Committee of T he World Scientific and Engineering Acade • Editorial Board International Journal of Intelligent Computing in Medical echnical Committee on medical informatics SMC society, USA • Editorial Board of Quality & Quantity, International Journal
• Honorary editorial board of Clinical and Experimental Gastroenterology
Referee for the following journals:
• BMC Medical Informatics and Decision Making
• Annals of Human Genetics
• Evidence Based Complementary and Alternative Medicine.
• Substance Use and Misuse
• International Journal of Intelligent Computing in Medical Sciences and
• Archives of Oral Biology • Health and quality of life outcomes • Journal of Experimental & Clinical Cancer Research GENERAL LIST OF PUBLICATIONS CITED ON PUB MED
1. Andriulli A, Neri M, Loguercio C, Terreni N, Merla A, Cardarella MP, Federico A, Chilovi F, Milandri GL, De Bona M, Cavenati S, Gullini S, Abbiati R, Garbagna N, Cerutti R, Grossi E. Clinical Trial on the Efficacy of a New Symbiotic Formulation, Flortec, in Patients With Irritable Bowel Syndrome: A Multicenter, Randomized Study. J Clin Gastroenterol. 2008 Aug 5. [Epub ahead of print]PMID: 18685503 [PubMed - as supplied by publisher] 2. Grossi E. The single individual in medicine: how to escape from the probability theory trap. Cases J. 2008 Jul 24;1(1):58.PMID: 18652690 [PubMed - in process] 3. Grossi E. The framingham study and treatment guidelines for stroke prevention. Curr Treat Options Cardiovasc Med. 2008 Jun;10(3):207-15.PMID: 18582409 [PubMed - in process] 4. Street ME, Grossi E, Volta C, Faleschini E, Bernasconi S. Placental determinants of fetal growth: identification of key factors in the insulin-like growth factor and cytokine systems using artificial neural networks. BMC Pediatr. 2008 Jun 17;8:24. PMID: 18559101 [PubMed - in process] 5. Penco S, Buscema M, Patrosso MC, Marocchi A, Grossi E. New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic background. BMC Bioinformatics. 2008 May 30;9:254. PMID: 18513389 [PubMed - in process] 6. Rossini PM, Buscema M, Capriotti M, Grossi E, Rodriguez G, Del Percio C, Babiloni C. Is it possible to automatically distinguish resting EEG data of normal elderlyvs. mild cognitive impairment subjects with high degree of accuracy? Clin Neurophysiol. 2008 Jul;119(7):1534-1545. Epub 2008 May 15.PMID: 18485814 [PubMed - as supplied by publisher] 7. Licastro F, Porcellini E, Chiappelli M, Forti P, Buscema M, Ravaglia G, GrossiE. Multivariable network associated with cognitive decline and dementia. Neurobiol Aging. 2008 May 14. [Epub ahead of print]PMID: 18485535 [PubMed - as supplied by publisher] 8. Helgason CM, Grossi E, Pandey D, Valika A, Cursio J, Brace LD.Platelet aggregation and recruitment with aspirin-clopidogrel therapy.Cerebrovasc Dis. 2008;25(5):392-400. Epub 2008 Mar 17.PMID: 18349532 [PubMed - in process] 9. Buscema M, Capriotti M, Bergami F, Babiloni C, Rossini P, Grossi E.The implicit function as squashing time model: a novel parallel nonlinear EEG analysis technique distinguishing mild cognitive impairment and Alzheimer's disease subjects with high degree of accuracy. Comput Intell Neurosci. 2007:35021.PMID: 18309366 [PubMed - in process] 10. Lahner E, Intraligi M, Buscema M, Centanni M, Vannella L, Grossi E, AnnibaleB.Artificial neural networks in the recognition of the presence of thyroid disease in patients with atrophic body gastritis.World J Gastroenterol. 2008 Jan 28;14(4):563-568.PMID: 18203288 [PubMed - as supplied by publisher 11. De Vreese LP, Caffarra P, Savarè R, Cerutti R, Franceschi M, Grossi E.Functional disability in early Alzheimer's disease - a validation study of the italian version of the disability assessment for dementia scale.Dement Geriatr Cogn Disord. 2008;25(2):186-94. Epub 2008 Jan 15.PMID: 18196940 [PubMed - in process] 12. Andriulli A, Grossi E, Buscema M, Pilotto A, Festa V, Perri F. Artificial neural networks can classify uninvestigated patients with dyspepsia. Eur J Gastroenterol Hepatol. 2007 Dec;19(12):1055-8. PMID: 17998828 [PubMed - in process] 13. Grossi E, Buscema M. Introduction to artificial neural networks. Eur J Gastroenterol Hepatol. 2007 Dec;19(12):1046-54. PMID: 17998827 [PubMed - in process] 14. Franceschi M, Caffarra P, De Vreese L, Pelati O, Pradelli S, Savarè R, Cerutti R, Grossi E. Visuospatial planning and problem solving in Alzheimer's disease patients: a study with the tower of london test. Dement Geriatr Cogn Disord. 2007;24(6):424-8. Epub 2007 Oct 16. PMID: 17940336 [PubMed - in process] Technology transfer from the science of medicine to the real world: the potential role played by artificial adaptive systems. Subst Use Misuse. 2007;42(2-3):267-304. PMID: 17558931 [PubMed - in process] 16. Grossi E, Buscema MP, Snowdon D, Antuono P. Neuropathological findings processed by artificial neural networks (ANNs) can perfectly distinguish Alzheimer's patients from controls in the Nun Study. BMC Neurol. 2007 Jun 21;7:15. PMID: 17584929 [PubMed - indexed for MEDLINE] 17. Buscema M, Rossini P, Babiloni C, Grossi E. The IFAST model, a novel parallel nonlinear EEG analysis technique, distinguishes mild cognitive impairment and Alzheimer's disease patients with high degree of accuracy. Artif Intell Med. 2007 Jun;40(2):127-41. Epub 2007 Apr 26. PMID: 17466496 [PubMed - indexed for MEDLINE] Non-linear associations between laryngo-pharyngeal symptoms of gastro-oesophageal reflux disease: clues from artificial intelligence analysis. Acta Otorhinolaryngol Ital. 2006 Oct;26(5):293-8. PMID: 17345935 [PubMed - indexed for MEDLINE] International experience on the use of artificial neural networks in gastroenterology. Dig Liver Dis. 2007 Mar;39(3):278-85. Epub 2007 Feb 1. Review. PMID: 17275425 [PubMed - indexed for MEDLINE] 20. Peluso I, Fina D, Caruso R, Stolfi C, Caprioli F, Fantini MC, Caspani G, Grossi E, Di Iorio L, Paone FM, Pallone F, Monteleone G. Lactobacillus paracasei subsp. paracasei B21060 suppresses human T-cell proliferation. Infect Immun. 2007 Apr;75(4):1730-7. Epub 2007 Jan 22. PMID: 17242060 [PubMed - indexed for MEDLINE] 21. Morelli L, Garbagna N, Rizzello F, Zonenschain D, Grossi E. In vivo association to human colon of Lactobacillus paracasei B21060: map from biopsies. Dig Liver Dis. 2006 Dec;38(12):894-8. Epub 2006 Sep 20. PMID: 16987720 [PubMed - indexed for MEDLINE] 22. Grossi E, Colombo R, Cavuto S, Franzini C. Age and gender relationships of serum alanine aminotransferase values in healthy subjects. Am J Gastroenterol. 2006 Jul;101(7):1675-6. No abstract available. PMID: 16863581 [PubMed - indexed for MEDLINE] 23. Andriulli A, Annese V, Terruzzi V, Grossi E, Minoli G. "Appropriateness" or "prioritization" for GI endoscopic procedures? Gastrointest Endosc. 2006 Jun;63(7):1034-6. No abstract available. PMID: 16733121 [PubMed - indexed for MEDLINE] How artificial intelligence tools can be used to assess individual patient risk in cardiovascular disease: problems with the current methods. BMC Cardiovasc Disord. 2006 May 3;6:20. PMID: 16672045 [PubMed - indexed for MEDLINE] 25. De Vreese LP, Pradelli S, Massini G, Buscema M, Savare R, Grossi E. The traveling salesman problem as a new screening test in early Alzheimer's disease: an exploratory study. Visual problem-solving in AD. Aging Clin Exp Res. 2005 Dec;17(6):458-64. PMID: 16485863 [PubMed - indexed for MEDLINE] 26. Grossi E, Dalle Grave R, Mannucci E, Molinari E, Compare A, Cuzzolaro M, Marchesini G. Complexity of attrition in the treatment of obesity: clues from a structured telephone interview. Int J Obes (Lond). 2006 Jul;30(7):1132-7. Epub 2006 Jan 24. PMID: 16432536 [PubMed - indexed for MEDLINE] 27. Dal Forno G, Chiovenda P, Bressi F, Ferreri F, Grossi E, Brandt J, Rossini PM, Pasqualetti P. Use of an Italian version of the telephone interview for cognitive status in Alzheimer's disease. Int J Geriatr Psychiatry. 2006 Feb;21(2):126-33. PMID: 16416467 [PubMed - indexed for MEDLINE] 28. Lahner E, Grossi E, Intraligi M, Buscema M, Corleto VD, Delle Fave G, Possible contribution of artificial neural networks and linear discriminant analysis in recognition of patients with suspected atrophic body gastritis. World J Gastroenterol. 2005 Oct 7;11(37):5867-73. PMID: 16270400 [PubMed - indexed for MEDLINE] 29. Penco S, Grossi E, Cheng S, Intraligi M, Maurelli G, Patrosso MC, Marocchi A, Buscema M. Assessment of the role of genetic polymorphism in venous thrombosis through artificial neural networks. Ann Hum Genet. 2005 Nov;69(Pt 6):693-706. PMID: 16266408 [PubMed - indexed for MEDLINE] Medical concepts related to individual risk are better explained with "plausibility" rather than "probability". BMC Cardiovasc Disord. 2005 Sep 27;5:31. PMID: 16188041 [PubMed - indexed for MEDLINE] 31. Grossi E, Massini G, Buscema M, Savare R, Maurelli G. Two different Alzheimer diseases in men and women: clues from advanced neural networks and artificial intelligence. Gend Med. 2005 Jun;2(2):106-17. PMID: 16115605 [PubMed - indexed for MEDLINE] 32. Di Luca M, Grossi E, Borroni B, Zimmermann M, Marcello E, Colciaghi F, Gardoni F, Intraligi M, Padovani A, Buscema M. Artificial neural networks allow the use of simultaneous measurements of Alzheimer disease markers for early detection of the disease. J Transl Med. 2005 Jul 27;3:30. PMID: 16048651 [PubMed] 33. Buscema M, Grossi E, Intraligi M, Garbagna N, Andriulli A, Breda M. An optimized experimental protocol based on neuro-evolutionary algorithms application to the classification of dyspeptic patients and to the prediction of the effectiveness of their treatment. Artif Intell Med. 2005 Jul;34(3):279-305. PMID: 16023564 [PubMed - indexed for MEDLINE] 34. Grossi E, Colombo R, Cavuto S, Franzini C. The REALAB project: a new method for the formulation of reference intervals based on current data. Clin Chem. 2005 Jul;51(7):1232-40. Epub 2005 May 26. PMID: 15919879 [PubMed - indexed for MEDLINE] 35. Pace F, Buscema M, Dominici P, Intraligi M, Baldi F, Cestari R, Passaretti S, Bianchi Porro G, Grossi E. Artificial neural networks are able to recognize gastro-oesophageal reflux disease patients solely on the basis of clinical data. Eur J Gastroenterol Hepatol. 2005 Jun;17(6):605-10. PMID: 15879721 [PubMed - indexed for MEDLINE] 36. Buscema M, Grossi E, Snowdon D, Antuono P, Intraligi M, Maurelli G, Savare R. Artificial neural networks and artificial organisms can predict Alzheimer athology in individual patients only on the basis of cognitive and functional tatus. Neuroinformatics. 2004;2(4):399-416. PMID: 15800371 [PubMed - indexed for MEDLINE] 37. Baldassarre D, Grossi E, Buscema M, Intraligi M, Amato M, Tremoli E, Pustina L, Castelnuovo S, Sanvito S, Gerosa L, Sirtori CR. Recognition of patients with cardiovascular disease by artificial neural networks. Ann Med. 2004;36(8):630-40. PMID: 15768835 [PubMed - indexed for MEDLINE] Greek kleroteria: the first randomisation technique? Lancet. 2005 Jan 15-21;365(9455):216. No abstract available. PMID: 15652603 [PubMed - indexed for MEDLINE] 39. Marchesini G, Pontiroli A, Salvioli G, Novi RF, Vitacolonna E, Taboga C, Ciccarone AM, Grossi E; QUOVADIS Study Group. Snoring, hypertension and Type 2 diabetes in obesity. Protection by physical activity. J Endocrinol Invest. 2004 Feb;27(2):150-7. PMID: 15129810 [PubMed - indexed for MEDLINE] 40. Marchesini G, Melchionda N, Apolone G, Cuzzolaro M, Mannucci E, Corica F, Grossi E; QUOVADIS Study Group. The metabolic syndrome in treatment-seeking obese persons. Metabolism. 2004 Apr;53(4):435-40. PMID: 15045688 [PubMed - indexed for MEDLINE] 41. Rodriguez G, De Leo C, Girtler N, Vitali P, Grossi E, Nobili F. Psychological and social aspects in management of Alzheimer's patients: an inquiry among caregivers. Neurol Sci. 2003 Dec;24(5):329-35. PMID: 14716528 [PubMed - indexed for MEDLINE] 42. Morelli L, Zonenschain D, Callegari ML, Grossi E, Maisano F, Fusillo M. Assessment of a new synbiotic preparation in healthy volunteers: survival, persistence of probiotic strains and its effect on the indigenous flora. Nutr J. 2003 Oct 9;2:11. PMID: 14613507 [PubMed] 43. Melchionda N, Marchesini G, Apolone G, Cuzzolaro M, Mannucci E, Grossi E; QUOVADIS Study Group. The QUOVADIS Study: features of obese Italian patients seeking treatment at specialist centers. Diabetes Nutr Metab. 2003 Apr;16(2):115-24. PMID: 12846451 [PubMed - indexed for MEDLINE] 44. Andriulli A, Grossi E, Buscema M, Festa V, Intraligi NM, Dominici P, Cerutti R, Perri F; NUD LOOK Study Group. Contribution of artificial neural networks to the classification and treatment of patients with uninvestigated dyspepsia. Dig Liver Dis. 2003 Apr;35(4):222-31. PMID: 12801032 [PubMed - indexed for MEDLINE] 45. Perri F, Festa V, Grossi E, Garbagna N, Leandro G, Andriulli A; "NUD-LOOK" Study Group. Dyspepsia and Helicobacter pylori infection: a prospective multicentre observational study. Dig Liver Dis. 2003 Mar;35(3):157-64. PMID: 12779069 [PubMed - indexed for MEDLINE] 46. Mecocci P, Grossi E, Buscema M, Intraligi M, Savare R, Rinaldi P, Cherubini A, Senin U. Use of artificial networks in clinical trials: a pilot study to predict responsiveness to donepezil in Alzheimer's disease. J Am Geriatr Soc. 2002 Nov;50(11):1857-60. PMID: 12410907 [PubMed - indexed for MEDLINE] 47. Macchia M, Barontini S, Bertini S, Di Bussolo V, Fogli S, Giovannetti E, Grossi E, Minutolo F, Danesi R. Design, synthesis, and characterization of the antitumor activity of novel ceramide analogues. J Med Chem. 2001 Nov 8;44(23):3994-4000. PMID: 11689086 [PubMed - indexed for MEDLINE] 48. Bellentani S, Grossi E, Dominici P, Tiribelli C. [The epidemiology and modes of transmission of Helicobacter pylori infection] Recenti Prog Med. 2000 Apr;91(4):171-4. Review. Italian. No abstract available. PMID: 10804749 [PubMed - indexed for MEDLINE] 49. Rivolta G, Cerutti R, Colombo R, Miano G, Dionisio P, Grossi E. Prevalence of subclinical hypothyroidism in a population living in the Milan metropolitan area. J Endocrinol Invest. 1999 Oct;22(9):693-7. PMID: 10595833 [PubMed - indexed for MEDLINE] 50. Dominici P, Bellentani S, Di Biase AR, Saccoccio G, Le Rose A, Masutti F, Viola L, Balli F, Tiribelli C, Grilli R, Fusillo M, Grossi E. Familial clustering of Helicobacter pylori infection: population based study. BMJ. 1999 Aug 28;319(7209):537-40. PMID: 10463891 [PubMed - indexed for MEDLINE] 51. Perri F, Clemente R, Festa V, De Ambrosio CC, Quitadamo M, Fusillo M, Grossi E, Andriulli A. Serum tumour necrosis factor-alpha is increased in patients with Helicobacter pylori infection and CagA antibodies. Ital J Gastroenterol Hepatol. 1999 May;31(4):290-4. PMID: 10425573 [PubMed - indexed for MEDLINE] 52. Cerutti R, Rivolta G, Cavalieri L, Di Giulio C, Grossi E, Vago T, Baldi G, Righini V, Marzo A. Bioequivalence of levothyroxine tablets administered to a target population in steady state. Pharmacol Res. 1999 Mar;39(3):193-201. PMID: 10094844 [PubMed - indexed for MEDLINE] 53. Loiudice L, Abbiati R, Boselli F, Cecchini G, Costa S, Grossi E, Piccoli R, Improvement of Pap smear sensitivity using a visual adjunctive procedure: a co-operative Italian study on speculoscopy (GISPE). Eur J Cancer Prev. 1998 Aug;7(4):295-304. PMID: 9806118 [PubMed - indexed for MEDLINE] Economic evaluations in medicine: still more questions than answers? Ital J Gastroenterol Hepatol. 1998 Aug;30(4):347-50. No abstract available. PMID: 9789124 [PubMed - indexed for MEDLINE] 55. Gismondo MR, Drago L, Fassina MC, Vaghi I, Abbiati R, Grossi E. Immunostimulating effect of oral glutamine. Dig Dis Sci. 1998 Aug;43(8):1752-4. PMID: 9724164 [PubMed - indexed for MEDLINE] 56. Bona M, Santini F, Rivolta G, Grossi E, Grilli R. Cost effectiveness of screening for subclinical hypothyroidism in the elderly. A decision-analytical model. Pharmacoeconomics. 1998 Aug;14(2):209-16. PMID: 10186461 [PubMed - indexed for MEDLINE] 57. Sacco C, Braghiroli A, Grossi E, Donner CF. The effects of doxofylline versus theophylline on sleep architecture in COPD patients. Monaldi Arch Chest Dis. 1995 Apr;50(2):98-103. PMID: 7613555 [PubMed - indexed for MEDLINE] 58. Garagiola U, Buzzetti M, Cardella E, Confalonieri F, Giani E, Polini V, Ferrante P, Mancuso R, Montanari M, Grossi E, et al. Immunological patterns during regular intensive training in athletes: quantification and evaluation of a preventive pharmacological approach. J Int Med Res. 1995 Mar-Apr;23(2):85-95. PMID: 7601298 [PubMed - indexed for MEDLINE] 59. Giannessi D, Lazzerini G, Filipponi P, Mannarelli C, Vaiani G, Grossi E, De Caterina R. Effects of nabumetone, a new non-steroidal anti-inflammatory drug, on urinary prostaglandin excretion in man. Pharmacol Res. 1993 Oct-Nov;28(3):229-41. PMID: 8108313 [PubMed - indexed for MEDLINE] 60. De Caterina R, Giannessi D, Lazzerini G, Filipponi P, Mannarelli C, Vaiani G, Grossi E. Effect of nabumetone on metabolism of renal arachidonate in humans. J Rheumatol Suppl. 1992 Nov;36:80. No abstract available. PMID: 1474540 [PubMed - indexed for MEDLINE] 61. Lazzaroni M, Grossi E, Bianchi Porro G. The effect of intravenous doxofylline or aminophylline on gastric secretion in duodenal ulcer patients. Aliment Pharmacol Ther. 1990 Dec;4(6):643-9. PMID: 2129651 [PubMed - indexed for MEDLINE] Meta-analysis of Italian clinical trials of nabumetone. Drugs. 1990;40 Suppl 5:48-9. No abstract available. PMID: 2150505 [PubMed - indexed for MEDLINE] 63. Movilia P, Restelli L, Miriano F, Vaiani G, Grossi E. Analgesic activity of nabumetone in postoperative pain. Drugs. 1990;40 Suppl 5:71-4. No abstract available. PMID: 2081499 [PubMed - indexed for MEDLINE] Doxofylline, an adenosine-nonblocking xanthine, does not induce cardiostimulant effects. Res Commun Chem Pathol Pharmacol. 1989 Jul;65(1):21-34. PMID: 2781149 [PubMed - indexed for MEDLINE] 65. Melillo G, Balzano G, Jodice F, De Felice A, Campisi V, Capone M, Di Filippo A, Foddai G, Franzone JS, Grossi E, et al. Treatment of reversible chronic airways obstruction with doxofylline compared with slow-release theophylline: a double-blind, randomized, multicentre trial. Int J Clin Pharmacol Res. 1989;9(6):397-405. PMID: 2699466 [PubMed - indexed for MEDLINE] 66. Grossi E, Biffignandi P, Franzone JS. [Doxofylline: pharmacologic profile and a review of clinical studies] Riv Eur Sci Med Farmacol. 1988 Nov;10(5):415-30. Review. Italian. No abstract available. PMID: 3079129 [PubMed - indexed for MEDLINE] 67. Filipponi P, Mannarelli C, Pacifici R, Grossi E, Moretti I, Tini S, Carloni C, Blass A, Morucci P, Hruska KA, et al. Evidence for a prostaglandin-mediated bone resorptive mechanism in subjects with fasting hypercalciuria. Calcif Tissue Int. 1988 Aug;43(2):61-6. PMID: 3142668 [PubMed - indexed for MEDLINE] 68. Dolcetti A, Osella D, De Filippis G, Carnuccio C, Grossi E. Comparison of intravenously administered doxofylline and placebo for the treatment of severe acute airways obstruction. J Int Med Res. 1988 Jul-Aug;16(4):264-9. PMID: 3169372 [PubMed - indexed for MEDLINE] 69. Bettini R, Marrapodi E, Rapazzini P, Ambruzzi AM, Ferrario A, Grossi E. [Multiple myeloma: test of hypocalcemia induced by calcitonin] Recenti Prog Med. 1987 Jul-Aug;78(7-8):348-53. Italian. No abstract available. PMID: 3423406 [PubMed - indexed for MEDLINE] 70. Grossi E, Garagiola U, Marconi A, Broggini M. [New etiopathologic and therapeutic perspectives in ureteral colic. Evaluation of clinical experience with diclofenac sodium and indomethacin] Recenti Prog Med. 1986 Sep;77(9):429-33. Italian. No abstract available. PMID: 3541086 [PubMed - indexed for MEDLINE] 71. Corli O, Grossi E, Roma G, Battagliarin G. Correlation between subjective labour pain and uterine contractions: a clinical study. Pain. 1986 Jul;26(1):53-60. PMID: 3737231 [PubMed - indexed for MEDLINE] 72. Grossi E, Monza GC, Pollavini S, Bona L. NSAID ionisation in the management of soft-tissue rheumatism: role played by the drug, electrical stimulation and suggestion. Clin Exp Rheumatol. 1986 Jul-Sep;4(3):265-7. PMID: 3533340 [PubMed - indexed for MEDLINE] [Randomized multicenter study on the use of diclofenac in the treatment of primary dysmenorrhea. An analysis of the data relative to 878 patients] Minerva Ginecol. 1986 Jul-Aug;38(7-8):637-45. Italian. No abstract available. PMID: 3528924 [PubMed - indexed for MEDLINE] 74. Pesenti A, Riboni A, Basilico E, Grossi E. Antipyretic therapy in ICU patients: evaluation of low dose diclofenac sodium. Intensive Care Med. 1986;12(5):370-3. PMID: 3771916 [PubMed - indexed for MEDLINE] 75. Bettini R, Grossi E, Rapazzini P, Giardina G. Diclofenac sodium versus acetylsalicylic acid: a randomized study in febrile patients. J Int Med Res. 1986;14(2):95-100. PMID: 3516755 [PubMed - indexed for MEDLINE] 76. Lenzi A, Lazzerini F, Grossi E, Massimetti G, Placidi GF. Use of carbamazepine in acute psychosis: a controlled study. J Int Med Res. 1986;14(2):78-84. PMID: 3084316 [PubMed - indexed for MEDLINE] 77. Bianchi Porro G, Lazzaroni M, Grossi E. Effect of maprotiline on pentagastrin-stimulated acid secretion in man. Scand J Gastroenterol. 1985 Oct;20(8):912-6. PMID: 4081627 [PubMed - indexed for MEDLINE] 78. Broggini M, Corbetta E, Grossi E, Borghi C. [Sodium diclofenac in ureteral colic. Comparative double-blind study with placebo] Minerva Urol Nefrol. 1985 Oct-Dec;37(4):493-7. Italian. No abstract available. PMID: 3834631 [PubMed - indexed for MEDLINE] Role of initial pain intensity in placebo-induced analgesia in ureteral colic. Pain. 1985 May;22(1):97-9. No abstract available. PMID: 4011287 [PubMed - indexed for MEDLINE] 80. Bossi L, Galante G, Conoscente F, Avvisati O, Grossi E. [Treatment of postoperative pain. Double-blind comparison of diclofenac and pentazocine] Minerva Anestesiol. 1984 Jul-Aug;50(7-8):373-8. Italian. No abstract available. PMID: 6395037 [PubMed - indexed for MEDLINE] 81. Broggini M, Corbetta E, Grossi E, Borghi C. Diclofenac sodium in biliary colic: a double blind trial. Br Med J (Clin Res Ed). 1984 Apr 7;288(6423):1042. No abstract available. PMID: 6423186 [PubMed - indexed for MEDLINE] Ionization with diclofenac sodium in rheumatic disorders: a double-blind placebo-controlled trial. J Int Med Res. 1984;12(6):346-50. PMID: 6394405 [PubMed - indexed for MEDLINE] 83. Corli O, Roma G, Bacchini M, Battagliarin G, Di Piazza D, Brambilla C, Grossi E. Double-blind placebo-controlled trial of baclofen, alone and in combination, in patients undergoing voluntary abortion. Clin Ther. 1984;6(6):800-7. PMID: 6391666 [PubMed - indexed for MEDLINE] 84. Grossi E, Borghi C, Cerchiari EL, Della Puppa T, Francucci B. Analogue chromatic continuous scale (ACCS): a new method for pain assessment. Clin Exp Rheumatol. 1983 Oct-Dec;1(4):337-40. PMID: 6681150 [PubMed - indexed for MEDLINE] [Multicenter study on the use of injectable diclofenac in pain states: analysis of the clinical data on 1873 patients] Clin Ter. 1983 Sep 30;106(6):447-56. Italian. No abstract available. PMID: 6641106 [PubMed - indexed for MEDLINE] 86. Bonelli S, Conoscente F, Movilia PG, Restelli L, Francucci B, Grossi E. Regional intravenous guanethidine vs. stellate ganglion block in reflex sympathetic dystrophies: a randomized trial. Pain. 1983 Jul;16(3):297-307. PMID: 6350994 [PubMed - indexed for MEDLINE] 87. Vignoni A, Fierro A, Moreschini G, Cau M, Agostino A, Daniele E, Foti G, Grossi E. Diclofenac sodium in ureteral colic: a double-blind comparison trial with placebo. J Int Med Res. 1983;11(5):303-7. 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Drug Name -- Buspar Alternate Names – Buspirone Manufacturer – Bristol-Myers Squibb Type – Prescription (not controlled). Pregnancy Issues – FDA Pregnancy Class B. Buspar is not expected to cause harm to a fetus or to cause birth defects. This, however, has not been proven over time. It is not known whether or not Buspar is transplacental. It is not known whether or not


1. How many single rooms are available to NHS patients at each of your Trusts hospital sites? 1.1. Of these how many have: an ensuite toilet? 1.2. Of these how many have: an ensuite toilet and shower or bath? 2. Please indicate which hospital sites within your trust operate an accident and emergency unit: 3. How many speciali

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