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The baby beat - november 8, 2006

THE BABY BEAT – June 22, 2011
D. Gary Benfield, M.D.
Which of these seasonal allergy drugs is safe for
pregnant women?

DEAR DR. BENFIELD: I suffer from seasonal allergies, and I'm three
months pregnant. Can you tell me which of these three nonprescription drugs is safe for my baby: Zyrtec, Allegra or Claritin? I can save some money if I buy my drug store's brand (WalMart, in this case) instead of buying the name brand. Would it be safe for my baby to do that? L.S.
DEAR L.S.: Before we go any further, please be sure to check with your
doctor before taking any drug during your pregnancy. That said, the active ingredient in Zyrtec is the antihistamine cetirizine, which has been assigned by the FDA to pregnancy risk category B. The active ingredient in Claritin is the antihistamine loratadine, which has also been assigned to pregnancy risk category B. However, fexofenadine, the active ingredient in Allegra, belongs to pregnancy risk category C. In general, drugs that belong to pregnancy risk category B are considered somewhat safer in pregnancy than drugs in category C. However, none of these drugs should be used in pregnancy unless clearly indicated. That's where your doctor comes in. He or she is in a better position to help you decide if the benefit of taking the medicine outweighs any potential risk for you and your baby. Certainly, it doesn't do your baby any good for you to suffer from seasonal allergies for days on end when one of these medications might provide relief. Which of these seasonal allergy drugs is safe for pregnant women?
One of the guiding principles pharmacists use when recommending a nonprescription drug in pregnancy is to choose the one that has the been approved the longest for over-the-counter (OTC) sale. Thus the drug will have the longest track record of safety. In this case, loratadine, the active ingredient in Claritin, was approved for OTC sale in 2002, whereas the other two active ingredients, cetirizine and fexofenadine, were approved much There is no reason, medically, for you to buy one of these name brands when WalMart's in-house brand (Equate) has the same active ingredient and will work just as well. And, you are correct: WalMart's Equate brand of cetirizine, loratadine, or fexofenadine will be cheaper. For example, I went on line to WalMart's pharmacy and found the following prices for Claritin and the Equate brand of loratadine, the active ingredient in Claritin:  Thirty tablets of Claritin, containing 10 mg of loratadine per tablet (24- hour relief), sells for $15.00, which comes to 50 cents per tablet.  Sixty, 10 mg tablets of loratadine (24-hour relief) under Walmart's Equate brand sells for $7.42, which comes to 13 cents per tablet. The bottom line? Check with your doctor concerning which of the three drugs he or she might recommend for your seasonal allergies. Always buy your drug store's in-house brand of the active ingredient unless your doctor has a good medical reason for preferring the name brand. Which of these seasonal allergy drugs is safe for pregnant women?
A further thought: Unfortunately, the FDA does not require drug
manufacturers to place the pregnancy risk category (A, B, C, D or X) of each active ingredient in drugs sold over-the-counter on the drug label. Thus, pregnant women, as well as their doctors, cannot tell which active ingredients are safer than others. That's why I've published my latest book, "Nonprescription Drugs in Pregnancy: Your Guide to Fetal Risk for the Active Ingredients in 500 Over-The-Counter Drugs." The book is available at www.Amazon.com, major book retailers, and at www.AtlasBooks.com. It comes in two sizes: regular paperback and pocket size. It can also be downloaded to any digital device, such as the Kindle, iPad, and Blackberry. I To my knowledge, the information gathered in this unique book has not been published, all in one place, before.

Source: http://walkingthebabybeat.com/assets-column/THE%20BABY%20BEAT%20-%20062211.pdf


0022-3565/02/3012-631–637$7.00THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICSCopyright © 2002 by The American Society for Pharmacology and Experimental TherapeuticsNongenomic Regulation of the Kinetics of Exocytosisby EstrogensJOS ´E D. MACHADO, CARMEN ALONSO, ARACELI MORALES, JOS ´E F. G ´ Unidad de Farmacologı´a (J.D.M., C.A., J.F.G., R.B.) and Laboratorio de Neurobiologı


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